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Dissecting Paracrine Effectors for Mesenchymal Stem Cells

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Mesenchymal Stem Cells - Basics and Clinical Application I

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 129))

Abstract

There has been increasing interest in the application of mesenchymal stem cells (MSCs) in regenerative medicine in recent years. In this context, the beneficial effects of MSCs have been ascribed mainly to a paracrine action rather than to direct replacement of the injured tissue. Indeed, MSCs produce a great variety of trophic and immunomodulatory factors. In this chapter, we provide an overview of growth factors and chemokines involved in stimulation of cell proliferation, inhibition of apoptosis, enhancement of angiogenesis, and suppression of inflammatory and immune response. In addition, we discuss the emerging role of the extracellular vesicles released from MSCs as possible paracrine mediators.

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Abbreviations

AKI:

Acute kidney injury

Akt-MSCs:

Mesenchymal stem cells overexpressing the Akt gene

ALI:

Acute lung injury

Ang-1:

Angiopoietin-1

bFGF:

Basic fibroblast growth factor

CM:

Conditioned medium

HGF:

Hepatocyte growth factor

IDO:

Indoleamine 2,3-deoxygenase

IGF-1:

Insulin-like growth factor 1

IL-6:

Interleukin-6

KGF:

Keratinocyte growth factor

mRNA:

Messenger RNA

MSC:

Mesenchymal stem cell

MV:

Microvesicle

NK:

Natural killer

PGE2:

Prostaglandin E2

siRNA:

Small interfering RNA

TGF-β:

Transforming growth factor β

Treg :

Regulatory T cells

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Internal Medicine and Molecular Biotechnology Center, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy

    Stefania Bruno, Federica Collino & Giovanni Camussi

  2. Fresenius Medical Care, Bad Homburg, Germany

    Ciro Tetta

Authors
  1. Stefania Bruno
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  2. Federica Collino
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  3. Ciro Tetta
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  4. Giovanni Camussi
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Corresponding author

Correspondence to Giovanni Camussi .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Carl-Neubergstr. 1, Hannover, 30625, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena, Modena, Italy

    Massimo Dominici

  3. Klinik für Frauenheilkunde und Geburtshi, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Ralf Hass

  4. Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, Wien, 1190, Austria

    Cornelia Kasper

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Bruno, S., Collino, F., Tetta, C., Camussi, G. (2012). Dissecting Paracrine Effectors for Mesenchymal Stem Cells. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application I. Advances in Biochemical Engineering/Biotechnology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_149

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