Abstract
The Biomedical Imaging Lab in Singapore has been involved in neuroinformatics research for more than a decade. We are focused on clinical neuroinformatics, developing suitable models, tools, and databases. We report here our work on construction of anatomical, vascular, and functional brain atlases as well as development of atlas-assisted neuroscience education, research, and clinical applications. We also present future research activities.
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References
Bhanu Prakash, K.N., Hu, Q., Volkau, I., Aziz, A., Nowinski, W.: Rapid and Automatic Localization of the Anterior and Posterior Commissure Point Landmarks in MR Volumetric Neuroimages. Hum Brain Mapp (submitted)
Fox, P.T., Mikiten, S., Davis, G., Lancaster, J.L.: BrainMap: A Database of Human Functional Brain Mapping. In: Thatcher, R., Hallett, M., Zeffiro, T., John, E., Huerta, M. (eds.) Functional Neuroimaging. Technical Foundations, pp. 95–106 (1994)
Gold, S., Christian, B., Arndt, S., Zeien, G., Cizadlo, T., Johnson, D.L., Flaum, M., Andreasen, N.C.: Functional MRI Statistical Software Packages: A Comparative Analysis. Hum. Brain Mapp. 6, 73–84 (1998)
Hu, Q., Nowinski, W.L.: A Rapid Algorithm for Robust and Automatic Extraction of the Midsagittal Plane of the Human Cerebrum from Neuroimages Based on Local Symmetry and Outlier Removal. Neuroimage 20(4), 2154–2166 (2003)
Hu, Q., Qian, G., Nowinski, W.L.: Fast, Accurate and Automatic Extraction of the Modified Talairach Cortical Landmarks from MR Images. Magn. Reson Med., 53 (2005)
Nowinski, W.L., Thirunavuukarasuu, A.: Atlas-Assisted Localization Analysis of Functional Images. Med. Image Anal., Sep. 5(3), 207–220 (2001)
Nowinski, W.L., Thirunavuukarasuu, A.: Electronic Atlases Show Value in Brain Studies. Diagn Imaging (Asia Pacific) 8(2), 35–39 (2001)
Nowinski, W.L.: Anatomical Targeting in Functional Neurosurgery by the Simultaneous Use of Multiple Schaltenbrand-Wahren Brain Atlas Microseries. Stereotact. Funct. Neurosurg. 71, 103–116 (1998)
Nowinski, W.L.: Computerized Brain Atlases for Surgery of Movement Disorders. Seminars in Neurosurgery 12(2), 183–194 (2001)
Nowinski, W.L., Thirunavuukarasuu, A., Volkau, I., Baimuratov, R., Hu, Q., Aziz, A., Huang, S.: Three-Dimensional Brain Atlas of Anatomy and Vasculature. Radiographics 25(1), 263–271 (2005)
Nowinski, W.L., Belov, D., Pollak, P., Benabid, A.L.: A Probabilistic Functional Atlas of the Human Subthalamic Nucleus. Neuroinformatics 2(4), 381–398 (2004)
Nowinski, W.L., Belov, D., Thirunavuukarasuu, A., Benabid, A.L.: A Probabilistic Functional Atlas of the VIM Nucleus. Scientific Program on CD, Poster presentation abstracts. In: American Association of Neurological Surgeons AANS 2005, New Orleans, Louisiana, USA, April 16-21 (2005)
Nowinski, W.L., Belov, D.: The Cerefy Neuroradiology Atlas: A Talairach-Tournoux Atlas-Based Tool for Analysis of Neuroimages. Neuroimage 20(1), 50–57 (2003), Available from www.cerefy.com
Nowinski, W.L., Belov, D., Benabid, A.: A Community-Centric Internet Portal for Stereotactic and Functional Neurosurgery with a Probabilistic Functional Atlas. Stereotact. Funct. Neurosurg. 79, 1–12 (2002)
Nowinski, W.L., Belov, D., Benabid, A.L.: An Algorithm for Rapid Calculation of a Probabilistic Functional Atlas of Subcortical Structures from Electrophysiological Data Collected During Functional Neurosurgery Procedures. Neuroimage 18(1), 143–155 (2003)
Nowinski, W.L., Benabid, A.L.: New Directions in Atlas-Assisted Stereotactic Functional Neurosurgery. In: Germano, I.M. (ed.) Advanced Techniques in Image-Guided Brain and Spine Surgery Thieme, New York (2001)
Nowinski, W.L., Bryan, R.N., Raghavan, R.: The Electronic Clinical Brain Atlas. Multiplanar Navigation of the Human Brain. Thieme, New York – Stuttgart (1997)
Nowinski, W.L., Fang, A., Nguyen, B.T., Raphel, J.K., Jagannathan, L., Raghavan, R., Bryan, R.N., Miller, G.: Multiple Brain Atlas Database and Atlas-Based Neuroimaging System. Comput Aided Surg 2(1), 42–66 (1997)
Nowinski, W.L., Hu, Q., Bhanu Prakash, K.N., Qian, G., Thirunavuukarasuu, A., Aziz, A.: Automatic Interpretation of Normal Brain Scans. In: The Radiological Society of North America, 90th Scientific Assembly & Annual Meeting Program, Chicago, Illinois, USA, p. 710 (2004)
Nowinski, W.L., Hu, Q., Bhanu Prakash, K.N., Volkau, I., Qian, G., Thirunavuukarasuu, A., Liu, J., Aziz, A., Baimouratov, R., Hou, Z., Huang, S., Luo, S., Minoshima, S., Runge, V., Beauchamp, N.: Atlas-Assisted Analysis of Brain Scans. In: Book of Abstracts of European Congress of Radiology ECR 2005, Eur. Radiol., vol. 15(suppl. 1), p. 572 (2005)
Nowinski, W.L.: Co-Registration of the Schaltenbrand-Wahren Microseries with the Probabilistic Functional Atlas. Stereotact Funct Neurosurg 82, 142–146 (2004)
Nowinski, W.L., Thirunavuukarasuu, A., Benabid, A.L.: The Cerefy Clinical Brain Atlas. Extended Edition with Surgery Planning and Intraoperative Support. Thieme, New York (2005)
Nowinski, W.L., Thirunavuukarasuu, A., Bryan, R.N.: The Cerefy Atlas of Brain Anatomy. An Interactive Reference Tool for Students. Teachers, and Researchers. Thieme, New York – Stuttgart (2002)
Nowinski, W.L., Thirunavuukarasuu, A., Kennedy, D.N.: Brain Atlas for Functional Imaging. Clinical and Research Applications. Thieme, New York – Stuttgart (2000)
Nowinski, W.L., Thirunavuukarasuu, A.: The Cerefy Clinical Brain Atlas on CD-ROM. Thieme, New York – Stuttgart (2004)
Nowinski, W.L., Yang, G.L., Yeo, T.T.: Computer-Aided Stereotactic Functional Neurosurgery Enhanced by the Use of the Multiple Brain Atlas Database. IEEE Trans. Med. Imaging 19(1), 62–69 (2000)
Nowinski, W.L., Yeo, T.T., Thirunavuukarasuu, A.: Microelectrode-Guided Functional Neurosurgery Assisted by Electronic Clinical Brain Atlas CD-ROM. Comput. Aided Surg. 3(3), 115–122 (1998)
Nowinski, W.L.: Electronic Brain Atlases: Features and Applications. In: Caramella, D., Bartolozzi, C. (eds.) 3D Image Processing: Techniques and Clinical Applications. Med. Radiol. series. Springer, Heidelberg (2002)
Nowinski, W.L.: Model Enhanced Neuroimaging: Clinical, Research, and Educational Applications. In: Yearbook of Medical Informatics, pp. 132–144 (2002)
Nowinski, W.L.: Modified Talairach Landmarks. Acta Neurochir. 143(10), 1045–1057 (2001)
Nowinski, W.L., Thirunavuukarasuu, A.: A Locus-Driven Mechanism for Rapid and Automated Atlas-Assisted Analysis of Functional Images by Using the Brain Atlas for Functional Imaging. Neurosurg. Focus. Jul. 15(1), Article 3 (2003)
Nowinski, W.L., Thirunavuukarasuu, A., Fu, Y., Ma, X., Lin, Z., Wang, S.: The Cerefy Clinical Brain Atlas. Chinese Edition. Harbin Institute of Technology, China (2005)
Nowinski, W.L.: The Cerefy Brain Atlases: Continuous Enhancement of the Electronic Talairach-Tournoux Brain Atlas. Neuroinformatics (2005) (in press)
Ono, M., Kubik, S., Abernathey, C.D.: Atlas of the Cerebral Sulci. Georg Thieme Verlag/Thieme Medical Publishers, Stuttgart - New York (1990)
Rajapakse, J.C., Srinivasan, D., Er, M.J., Huang, G.B., Wang, L.: Excerpts of Research in Brain Sciences and Neural Networks in Singapore. In: Proc. International Joint Conference on Neural Networks IJCNN 2004, Budapest, Hungary, pp. 369–375 (2004)
Robb, R.A., Hanson, D.P.: The ANALYZE Software System for Visualization and Analysis in Surgery Simulation. In: Lavallee, S., Tayor, R., Burdea, G., Mosges, R. (eds.) Computer Integrated Surgery, pp. 175–190. MIT Press, Cambridge (1995)
Schaltenbrand, G., Wahren, W.: Atlas for Stereotaxy of the Human Brain. Georg Thieme Verlag, Stuttgart (1977)
Serra, L., Nowinski, W.L., Poston, T., et al.: The Brain Bench: Virtual Tools for Stereotactic Frame Neurosurgery. Med. Image Anal. 1(4), 317–329 (1997)
Talairach, J., Tournoux, P.: Co-Planar Stereotactic Atlas of the Human Brain. Georg Thieme Verlag/Thieme Medical Publishers, Stuttgart - New York (1988)
Talairach, J., Tournoux, P.: Referentially Oriented Cerebral MRI Anatomy. Atlas of Stereotaxic Anatomical Correlations for Gray and White Matter. Georg Thieme Verlag/Thieme Medical Publishers, Stuttgart - New York (1993)
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Nowinski, W.L. (2005). Current Status and Future Research Activities in Clinical Neuroinformatics: Singaporean Perspective. In: Wang, L., Chen, K., Ong, Y.S. (eds) Advances in Natural Computation. ICNC 2005. Lecture Notes in Computer Science, vol 3610. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11539087_143
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DOI: https://doi.org/10.1007/11539087_143
Publisher Name: Springer, Berlin, Heidelberg
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