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Reaction Vessels Assembled by the Sequential Adsorption of Polymers

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Modern Techniques for Nano- and Microreactors/-reactions

Part of the book series: Advances in Polymer Science ((POLYMER,volume 229))

Abstract

Nanoengineered polymer carriers assembled by the layer-by-layer technique are being increasingly investigated as nano- to millimeter-sized, semi-permeable reactors. The reactors are assembled by the sequential adsorption of polymers that interact primarily via electrostatic forces, hydrogen bonding, or covalent bond formation onto a sacrificial colloidal template. Controlled permeability of molecular species is key to the functioning of these reactors and a number of techniques have been developed for measuring and controlling their permeability to both small molecules and larger macromolecules. The encapsulation of enzyme “machinery” into the carriers has produced a number of reactor examples capable of small molecule conversion. Advanced assembly techniques have been used to generate reactors with relevance to biomedicine, including biosensing, controlled drug release, and biopolymer synthesis.

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References

  1. Kiick K (2007) Polymer therapeutics. Science 317:1182–1183

    Article  CAS  Google Scholar 

  2. Duncan R (2003) The dawning era of polymer therapeutics. Nat Rev Drug Discov 2:347–360

    Article  CAS  Google Scholar 

  3. Lensen D, Vriezema DM, van Hest JCM (2008) Polymeric microcapsules for synthetic applications. Macromol Biosci 8:991–1005

    Article  CAS  Google Scholar 

  4. Decher G, Hong JD (1991) Buildup of ultrathin multilayer films by a self-assembly process. II. Consecutive absorption of anionic and cationic bipolar amphiphiles and polyelectrolytes on charged surfaces. Ber Bunsen Ges Phys Chem 95:1430–1434

    CAS  Google Scholar 

  5. Quinn JF, Johnston APR, Such GK, et al. (2007) Next generation, sequentially assembled ultrathin films: beyond electrostatics. Chem Soc Rev 36:707–718

    Article  CAS  Google Scholar 

  6. Caruso F, Caruso RA, Moehwald H (1998) Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating. Science 282:1111–1114

    Article  CAS  Google Scholar 

  7. Donath E, Sukhorukov GB, Caruso F, et al. (1998) Novel hollow polymer shells by colloid-templated assembly of polyelectrolytes. Angew Chem Int Ed 37:2202–2205

    Article  CAS  Google Scholar 

  8. Kurth DG, Volkmer D, Klitzing RV (2003) Multilayers on solid planar substrates: from structure to function. In: Decher G, Schlenoff JB (eds) Multilayer thin films. Wiley-VCH, Weinberg

    Google Scholar 

  9. Caruso F, Sukhorukov G (2003) Coated colloids: preparation, characterization, assembly and utilization. In: Decher G, Schlenoff JB (eds) Multilayer thin films. Wiley-VCH, Weinberg

    Google Scholar 

  10. Shiratori SS, Rubner R (2000) pH-dependent thickness behavior of sequentially absorbed layers of weak polyelectrolytes. Macromolecules 33:4213–4219

    Article  CAS  Google Scholar 

  11. Tong W, Gao C (2008) Multilayer microcapsules with tailored structures for bio-related applications. J Mater Chem 18:3799–3812

    Article  CAS  Google Scholar 

  12. Tong W, Gao C, Möhwald H (2005) Manipulating the properties of polyelectrolyte capsules by glutaraldehyde cross-linking. Chem Mater 4610–4616

    Google Scholar 

  13. Harris JJ, DeRose PM, Bruenig ML (1999) Synthesis of passivating, nylon-like coatings through cross-linking of ultrathin polyelectrolyte films. J Am Chem Soc 121:1978–1980

    Article  CAS  Google Scholar 

  14. Sun J, Wu T, Sun J, et al. (1998) Fabrication of covalently attached multilayer via photolysis of layer-by-layer self-assembled films containing diazo-resins. Chem Commun 17:1853–1855

    Article  Google Scholar 

  15. Pastoriza-Santos I, Schöler B, Caruso F (2001) Core-shell colloids and hollow polyelectrolyte capsules based on diazoresins. Adv Funct Mater 11:122–128

    Article  CAS  Google Scholar 

  16. Tong W, Gao C, Möhwald H (2006) Stable weak polyelectrolyte microcapsules with pH-responsive permeability. Macromolecules 39:335–340

    Article  CAS  Google Scholar 

  17. Stockton WB, Rubner MF (1997) Molecular-level processing of conjugated polymers. 4. Layer-by-layer manipulation of polyaniline via hydrogen-bonding interactions. Macromolecules 30:2717–2725

    Article  CAS  Google Scholar 

  18. Wang L, Wang ZQ, Zhang X, et al. (1997) A new approach for the fabrication of an alternating multilayers film of poly(4-vinylpyridine) and poly(acrylic acid) based on hydrogen bonding. Macromol Rapid Commun 18:509–514

    Article  CAS  Google Scholar 

  19. Kharlampieve E, Sukhishvili SA (2006) Hydrogen-bonded layer-by-layer polymer films. Macromol Sci Part C: Polymer Rev 46:377–395

    Article  Google Scholar 

  20. Kozlovskaya V, Kharlampieva E, Erel I, et al. (2009) Multilayer-derived, ultrathin, stimuli-responsive hydrogels. Soft Matter 5:4077–4087

    Article  CAS  Google Scholar 

  21. Kozlovskaya VA, Shamaev A, Sukhishvili SA (2008) Tuning swelling pH and permeability of hydrogel multilayer capsules. Soft Matter 4:1499–1507

    Article  CAS  Google Scholar 

  22. Wattendorf U, Kreft O, Textor M, et al. (2008) Stable stealth function for hollow polyelectrolyte microcapsules through a poly(ethylene glycol) grafted polyelectrolyte adlayer. Biomacromolecules 9:100–108

    Article  CAS  Google Scholar 

  23. Zelikin AN, Such GK, Postma A, et al. (2007) Poly(vinylpyrrolidone) for bioconjugation and surface ligand immobilization. Biomacromolecules 8:2950–2953

    Article  CAS  Google Scholar 

  24. Quinn JF, Caruso F (2004) Facile tailoring of film morphology. Langmuir 20:20–22

    Article  CAS  Google Scholar 

  25. Huang C-J, Chang F-C (2009) Using click chemistry to fabricate ultrathin thermoresponsive microcapsules through direct covalent layer-by-layer assembly. Macromolecules 42: 5155–5166

    Article  CAS  Google Scholar 

  26. Johnston APR, Read ES, Caruso F (2005) DNA multilayer films on planar and colloidal supports: sequential assembly of like-charged polyelectrolytes. Nano Lett 5:953–956

    Article  CAS  Google Scholar 

  27. Johnston APR, Mitomo H, Read ES, et al. (2006) Compositional and structural engineering of DNA multilayer films. Langmuir 22:3251–3258

    Article  CAS  Google Scholar 

  28. Lee L, Johnston APR, Caruso F (2008) Manipulating the salt and thermal stability of DNA multilayer films via oligonucleotide length. Biomacromolecules 9:3070–3078

    Article  CAS  Google Scholar 

  29. Johnston APR, Lee L, Wang Y, et al. (2009) Controlled degradation of DNA capsules with engineered restriction-enzyme cut sites. Small 5:1418–1421

    Article  CAS  Google Scholar 

  30. Yang SY, Rubner MF (2002) Micropatterning of polymer thin films with pH-sensitive cross-linkable hydrogen-bonded polyelectrolyte multilayers. J Am Chem Soc 124:2100–2101

    Article  CAS  Google Scholar 

  31. Yang SY, Lee D, Cohen RE, et al. (2004) Bioinert solution-cross-linked-hydrogen-bonded multilayers on colloidal particles. Langmuir 20:5978–5981

    Article  CAS  Google Scholar 

  32. Kozlovskaya VA, Kharlampieva EP, Mansfield ML, et al. (2006) Poly(methacrylic acid) hydrogel films and capsules: response to pH and ionic strength, and encapsulation of macromolecules. Chem Mater 5:328–336

    Article  Google Scholar 

  33. Connal LA, Kinnane CR, Zelikin AN, et al. (2009) Stabilization and functionalization of polymer multilayers and capsules via thiol-ene click chemistry. Chem Mater 21:27–30

    Article  Google Scholar 

  34. Zelikin AN, Quinn JF, Caruso F (2006) Disulfide cross-linked polymer capsules: en route to biodeconstructible systems. Biomacromolecules 7:27–30

    Article  CAS  Google Scholar 

  35. Zelikin AN, Li Q, Caruso F (2006) Degradable polyelectrolyte capsules filled with oligonucleotide sequences. Angew Chem Int Ed 45:7743–7745

    Article  CAS  Google Scholar 

  36. Becker AL, Zelikin AN, Johnston APR, et al. (2009) Tuning the formation and degradation of layer-by-layer assembled polymer hydrogel microcapsules. Langmuir. doi:10.1021/la901687a

    Google Scholar 

  37. De Rose R, Zelikin AN, Johnston APR, et al. (2008) Binding, internalization, and antigen presentation of vaccine-loaded nanoengineered capsules in blood. Adv Mater 20:4698–4703

    Article  Google Scholar 

  38. Sivakumar S, Bansal V, Cortez C, et al. (2009) Degradable, surfactant-free, monodisperse polymer-encapsulated emulsions as anticancer drug carriers. Adv Mater 21:1820–1824

    Article  CAS  Google Scholar 

  39. Kinnane CR, Such GK, Antequera-Garcia G, et al. (2009) Low-fouling poly(N-vinyl pyrollidone) capsules with engineered degradable properties. Biomacromolecules 10:2839–2846

    Article  CAS  Google Scholar 

  40. Kohli P, Blanchard GJ (2000) Applying polymer chemistry to interfaces: layer-by-layer and spontaneous growth of covalently bound multilayers. Langmuir 16:4655–4661

    Article  CAS  Google Scholar 

  41. Serizawa T, Nanemeki K, Yamanoto K, et al. (2002) Thermoresponsive ultrathin hydrogels prepared by sequential chemical reactions. Macromolecules 35:2184–2189

    Article  CAS  Google Scholar 

  42. Such GK, Quinn JF, Quinn A, et al. (2006) Assembly of ultrathin polymer multilayer films by click chemistry. J Am Chem Soc 128:9318–9319

    Article  CAS  Google Scholar 

  43. Such GK, Tjipto E, Postma A, et al. (2007) Ultrathin, responsive polymer click capsules. Nano Lett 7:1706–1710

    Article  CAS  Google Scholar 

  44. Ochs CJ, Such GK, Stadler B, et al. (2008) Low-fouling, biofunctionalized and biodegradable click capsules. Biomacromolecules 9:3389–3396

    Article  CAS  Google Scholar 

  45. Kinnane CR, Wark K, Such GK, et al. (2009) Peptide-functionalized, low-biofouling click multilayers for promoting cell adhesion and growth. Small 5:444–448

    Article  CAS  Google Scholar 

  46. Tong W, Gao C, Möhwald H (2006) Single polyelectrolyte microcapsules fabricated by glutaraldehyde-mediated covalent layer-by-layer assembly. Macromol Rapid Commun 27:2078–2083

    Article  CAS  Google Scholar 

  47. Ibarz G, Dahne L, Donath E, et al. (2002) Resealing of polyelectrolyte capsules after core removal. Macromol Rapid Commun 23:474–478

    Article  CAS  Google Scholar 

  48. Ibarz G, Dahne L, Donath E, et al. (2002) Controlled permeability of polyelectrolyte capsules via defined annealing. Chem Mater 14:4059–4062

    Article  CAS  Google Scholar 

  49. Köhler K, Sukhorukov GB (2007) Heat treatment of polyelectrolyte multilayer capsules: a versatile method for encapsulation. Adv Funct Mater 17:2053–2061

    Article  Google Scholar 

  50. Antipov AA, Sukhorukov GB, Leporatti S, et al. (2002) Polyelectrolyte multilayer capsule permeability control. Colloids Surf A 198:535–541

    Article  Google Scholar 

  51. Berth G, Voigt A, Dautzenberg H, et al. (2002) Polyelectrolyte complexes and layer-by-layer capsules from chitosan/chitosan sulfate. Biomacromolecules 3:517–524

    Article  Google Scholar 

  52. White JA, Deen WM (2002) Agarose-dextran gels as synthetic analogs of glomerular basement membrane: water permeability. Biophys J 82:2081–2089

    Article  CAS  Google Scholar 

  53. Petrov AI, Volodkin DV, Sukhorukov GB (2005) Protein-calcium carbonate coprecipitation: a tool for protein encapsulation. Biotechnol Progr 21:918–925

    Article  CAS  Google Scholar 

  54. Angelatos AS, Johnston APR, Wang Y, et al. (2007) Probing the permeability of polyelectrolyte multilayer capsules via a molecular beacon approach. Langmuir 23:4554–4562

    Article  CAS  Google Scholar 

  55. Johnston APR, Caruso F (2005) A molecular beacon approach to measuring the DNA permeability of thin films. J Am Chem Soc 127:10014–10015

    Article  CAS  Google Scholar 

  56. Tyagi S, Kramer FR (1996) Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 14:303–308

    Article  CAS  Google Scholar 

  57. Lee JF, Stovall GM, Ellington AD (2006) Aptamer therapeutics advance. Curr Opin Chem Biol 10:282–289

    Article  CAS  Google Scholar 

  58. Chong SF, Sexton A, De Rose R, et al. (2009) A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules. Biomaterials 30:5178–5186

    Article  CAS  Google Scholar 

  59. Hagerman PJ (1988) Flexibility of DNA. Annu Rev Biophys Biophys Chem 17:265–286

    Article  CAS  Google Scholar 

  60. Levicky RL, Herne TM, Tarlov MJ, et al. (1998) Using self-assembly to control the structure of DNA monolayers on gold: a neutron reflectivity study. J Am Chem Soc 120:9787–9792

    Article  CAS  Google Scholar 

  61. Zelikin AN, Becker AL, Johnston APR, et al. (2007) A general approach for DNA encapsulation in degradable polymer miocrocapsules. ACS Nano 1:63–69

    Article  CAS  Google Scholar 

  62. De Rose R, Zelikin AN, Johnston APR, et al. (2008) Binding, internalization, and antigen presentation of vaccine-loaded nanoengineered capsules in blood. Adv Mater 20:4698–4703

    Article  Google Scholar 

  63. Kozlovskaya VA, Kharlampieva EP, Erel-Unal I, et al. (2009) Single-component layer-by-layer weak polyelectrolyte films and capsules: loading and release of functional molecules. Polym Sci Ser A 51:719–729

    Article  Google Scholar 

  64. Tong W, Gao C, Mohwald H (2008) pH-responsive protein microcapsules fabricated via glutaraldehyde mediated covalent layer-by-layer assembly. Colloid Polym Sci 286:1103–1109

    Article  CAS  Google Scholar 

  65. Bédard MF, Braun D, Sukhorukov GB, et al. (2008) Toward self-assembly of nanoparticles on polymeric microshells: near-IR release and permeability. ACS Nano 2:1807–1816

    Article  Google Scholar 

  66. Park MK, Deng S, Advincula R (2004) Permeability and permselectivity control in photo-cross-linkable polyelectrolyte ultrathin films containing ph-switchable and benzophenone functional groups. Polym Mater Sci Eng 90:133–134

    CAS  Google Scholar 

  67. Johnston APR, Cortez C, Angelatos AS, et al. (2006) Layer-by-layer engineered capsules and their applications. Curr Opin Colloid Interface Sci 11:203–209

    Article  CAS  Google Scholar 

  68. Lvov Y, Antipov AA, Mamedov A, et al. (2001) Urease encapsulation in nanoorganized microshells. Nano Lett 1:125–128

    Article  CAS  Google Scholar 

  69. Tiourina OP, Antipov AA, Sukhorukov GB, et al. (2001) Entrapment of alpha-chymotrypsin into hollow polyelectrolyte microcapsules. Macromol Biosci 1:209–214

    Article  CAS  Google Scholar 

  70. Caruso F, Trau D, Mohwald H, et al. (2000) Enzyme encapsulation in layer-by-layer engineered polymer multilayer capsules. Langmuir 16:1485–1488

    Article  CAS  Google Scholar 

  71. Balabushevitch NG, Sukhorukov GB, Moroz NA, et al. (2001) Encapsulation of proteins by layer-by-layer adsorption of polyelectrolytes onto protein aggregates: factors regulating the protein release. Biotechnol Bioeng 76:207–213

    Article  CAS  Google Scholar 

  72. Volodkin DV, Balabushevitch NG, Sukhorukov GB, et al. (2003) Inclusion of proteins into polyelectrolyte microparticles by alternative adsorption of polyelectrolytes on protein aggregates. Biochem-Moscow 68:236–241

    Article  CAS  Google Scholar 

  73. Wang Y, Angelatos AS, Caruso F (2008) Template synthesis of nanostructured materials via layer-by-layer assembly. Chem Mater 20:848–858

    Article  CAS  Google Scholar 

  74. Wang Y, Price AD, Caruso F (2009) Nanoporous colloids: building blocks for a new generation of structured materials. J Mater Chem 19:6451–6464

    Article  CAS  Google Scholar 

  75. Wang Y, Caruso F (2005) Mesoporous silica spheres as supports for enzyme immobilization and encapsulation. Chem Mater 17:953–961

    Article  CAS  Google Scholar 

  76. Yu AM, Wang Y, Barlow E, et al. (2005) Mesoporous silica particles as templates for preparing enzyme-loaded biocompatible microcapsules. Adv Mater 17:1737–1741

    Article  CAS  Google Scholar 

  77. Yu AM, Gentle I, Lu GQ, et al. (2006) Nanoassembly of biocompatible microcapsules for urease encapsulation and their use as biomimetic reactors. Chem Commun 2150–2152

    Google Scholar 

  78. Volodkin DV, Petrov AI, Prevot M, et al. (2004) Matrix polyelectrolyte microcapsules: new system for macromolecule encapsulation. Langmuir 20:3398–3406

    Article  CAS  Google Scholar 

  79. Volodkin DV, Larionova NI, Sukhorukov GB (2004) Protein encapsulation via porous CaCO3 microparticles templating. Biomacromolecules 5:1962–1972

    Article  CAS  Google Scholar 

  80. Zhi ZL, Haynie DT (2006) High-capacity functional protein encapsulation in nanoengineered polypeptide microcapsules. Chem Commun 147–149

    Google Scholar 

  81. Srivastava R, Brown JQ, Zhu HG, et al. (2005) Stable encapsulation of active enzyme by application of multilayer nanofilm coatings to alginate microspheres. Macromol Biosci 5:717–727

    Article  CAS  Google Scholar 

  82. Mak WC, Bai J, Chang XY, et al. (2009) Matrix-assisted colloidosome reverse-phase layer-by-layer encapsulating biomolecules in hydrogel microcapsules with extremely high efficiency and retention stability. Langmuir 25:769–775

    Article  CAS  Google Scholar 

  83. Ciobanu M, Heurtault B, Schultz P, et al. (2007) Layersome: development and optimization of stable liposomes as drug delivery system. Int J Pharm 344:154–157

    Article  CAS  Google Scholar 

  84. Germain M, Grube S, Carriere V, et al. (2006) Composite nanocapsules: lipid vesicles covered with several layers of crosslinked polyelectrolytes. Adv Mater 18:2868–2871

    Article  CAS  Google Scholar 

  85. Stadler B, Chandrawati R, Goldie K, et al. (2009) Capsosomes: subcompartmentalizing polyelectrolyte capsules using liposomes. Langmuir 25:6725–6732

    Article  CAS  Google Scholar 

  86. Stadler B, Chandrawati R, Price AD, et al. (2009) A microreactor with thousands of subcompartments: enzyme-loaded liposomes within polymer capsules. Angew Chem Int Ed 48:4359–4362

    Article  CAS  Google Scholar 

  87. Chandrawati R, Stadler B, Postma A, et al. (2009) Cholesterol-mediated anchoring of enzyme-loaded liposomes within disulfide-stabilized polymer carrier capsules. Biomaterials 30:5988–5998

    Article  CAS  Google Scholar 

  88. Stein EW, Volodkin DV, McShane MJ, et al. (2006) Real-time assessment of spatial and temporal coupled catalysis within polyelectrolyte microcapsules containing coimmobilized mucose oxiase and peroxidase. Biomacromolecules 7:710–719

    Article  CAS  Google Scholar 

  89. Kreft O, Prevot M, Mohwald H, et al. (2007) Shell-in-shell microcapsules: a novel tool for integrated, spatially confined enzymatic reactions. Angew Chem Int Ed 46: 5605–5608

    Article  CAS  Google Scholar 

  90. Borodina T, Markvicheva E, Kunizhev S, et al. (2007) Controlled release of DNA from self-degrading microcapsules. Macromol Rapid Commun 28:1894–1899

    Article  CAS  Google Scholar 

  91. Price AD, Zelikin AN, Wang Y, et al. (2009) Triggered enzymatic degradation of DNA within selectively permeable polymer capsule microreactors. Angew Chem Int Ed 48:329–332

    Article  CAS  Google Scholar 

  92. Ghan R, Shutava T, Patel A, et al. (2004) Enzyme-catalyzed polymerization of phenols within polyelectrolyte microcapsules. Macromolecules 37:4519–4524

    Article  CAS  Google Scholar 

  93. Mak WC, Cheung KY, Trau D (2008) Diffusion controlled and temperature stable microcapsule reaction compartments for high-throughput microcapsule-PCR. Adv Funct Mater 18:2930–2937

    Article  CAS  Google Scholar 

  94. Price AD, Zelikin AN, Wark KL, et al. (2010) A biomolecular “ship in a bottle”: continuous RNA synthesis within hollow polymer hydrogel assemblies. Adv Mater. 22: 720–723

    Article  Google Scholar 

  95. Stadler B, Price AD, Chandrawati R, et al. (2009) Polymer hydrogel capsules: en route toward synthetic cellular systems. Nanoscale 1:68–73

    Article  CAS  Google Scholar 

  96. Wiemann LO, Buthe A, Klein M, et al. (2009) Encapsulation of synthetically valuable biocatalysts into polyelectrolyte multilayer systems. Langmuir 25:618–623

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia

    Andrew D. Price, Angus P. R. Johnston, Georgina K. Such & Frank Caruso

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  1. Andrew D. Price
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  2. Angus P. R. Johnston
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  3. Georgina K. Such
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  4. Frank Caruso
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Correspondence to Frank Caruso .

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  1. Dept. Chemical & Biomolecular, Engineering, University of Melbourne, Melbourne, 3010, Australia

    Frank Caruso

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Price, A.D., Johnston, A.P.R., Such, G.K., Caruso, F. (2010). Reaction Vessels Assembled by the Sequential Adsorption of Polymers. In: Caruso, F. (eds) Modern Techniques for Nano- and Microreactors/-reactions. Advances in Polymer Science, vol 229. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2009_44

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