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The role of reverse genetics systems in determining filovirus pathogenicity

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Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence

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Summary

The family Filoviridae is comprised of two genera: Marburgvirus and Ebolavirus. To date minigenome systems have been developed for two Ebola viruses (Reston ebolavirus and Zaire ebolavirus [ZEBOV]) as well as for Lake Victoria marburgvirus, the sole member of the Marburgvirus genus. The use of these minigenome systems has helped characterize functions for many viral proteins in both genera and have provided valuable insight towards the development of an infectious clone system in the case of ZEBOV. The recent development of two such infectious clone systems for ZEBOV now allow effective strategies for experimental mutagenesis to study the biology and pathogenesis of one of the most lethal human pathogens.

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Authors and Affiliations

  1. National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

    S. Theriault, A. Groseth, H. Artsob & H. Feldmann

  2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    S. Theriault, A. Groseth, H. Artsob & H. Feldmann

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  1. S. Theriault
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  2. A. Groseth
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  3. H. Artsob
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  4. H. Feldmann
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Editors and Affiliations

  1. Department of Pathology, WHO Collaborating Center for Tropical Diseases, University of Texas, Galveston, USA

    C. J. Peters

  2. Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA

    Charles H. Calisher

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Theriault, S., Groseth, A., Artsob, H., Feldmann, H. (2005). The role of reverse genetics systems in determining filovirus pathogenicity. In: Peters, C.J., Calisher, C.H. (eds) Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence. Springer, Vienna. https://doi.org/10.1007/3-211-29981-5_13

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