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Molecular Mechanisms of Poliovirus Variation and Evolution

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Quasispecies: Concept and Implications for Virology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 299))

Abstract

Replication of poliovirus RNA is accomplished by the error-prone viral RNA-dependent RNA polymerase and hence is accompanied by numerous mutations. In addition, genetic errors may be introduced by nonreplicative mechanisms. Resulting variability is manifested by point mutations and genomic rearrangements (e.g., deletions, insertions and recombination). After description of basic mechanisms underlying this variability, the review focuses on regularities of poliovirus evolution (mutation fixation) in tissue cultures, human organisms and populations.

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  1. M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782, Russia

    V. I. Agol

  2. M.V. Lomonosov Moscow State University, Moscow, 119899, Russia

    V. I. Agol

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  1. Centro de BiologÍa Molecular “Servero Ochoa” (CSIC-UAM), Universidad Autónoma de Madrid, 28049, Cantoblanco, Madrid, Spain

    Esteban Domingo

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Agol, V.I. (2006). Molecular Mechanisms of Poliovirus Variation and Evolution. In: Domingo, E. (eds) Quasispecies: Concept and Implications for Virology. Current Topics in Microbiology and Immunology, vol 299. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26397-7_8

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