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Translation and Replication of FMDV RNA

  • Chapter
Foot-and-Mouth Disease Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 288))

Abstract

Foot-and-mouth disease virus (FMDV) RNA is infectious. After delivery of the RNA (about 8.3 kb) into the cytoplasm of a cell, the RNA must initially be translated to produce the viral proteins required for RNA replication and for the packaging of the RNA into new virions. Subsequently there has to be a switch in the function of the RNA; translation has to be stopped to permit RNA replication. The signals required for the control of the different roles of viral RNA must be included within the viral RNA sequence. Many cellular proteins interact with the viral RNA and probably also with the virus-encoded proteins. The functions of different RNA elements within the viral RNA and the various virus-encoded proteins in determining the efficiency of virus replication are discussed. Unique aspects of FMDV RNA translation and replication are emphasised.

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  1. BBSRC Institute for Animal Health, Pirbright, Woking, Surrey, GU24 ONF, UK

    G. J. Belsham

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  1. Centers for Disease Control and Prevention, National Center for Infectious Diseases, Mailstop C 12, 1600 clifton road, Atlanta, GA, 30333, USA

    Brian W.J. Mahy

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Belsham, G.J. (2005). Translation and Replication of FMDV RNA. In: Mahy, B.W. (eds) Foot-and-Mouth Disease Virus. Current Topics in Microbiology and Immunology, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27109-0_3

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