Abstract
Pathogenic Yersinia species evade the innate cellular immune response by injecting antihost effector proteins (Yersinia outer proteins, Yops) into host cells through a type III secretion (TTS) apparatus. One of the six effector Yops, YopT, inactivates the small GTPase RhoA by removing the geranylgeranylated C-terminal cysteine. This cleavage results in release of RhoA from the cell membrane and subsequently in blockage of stress fiber formation. Thus YopT impairs cellular functions associated with cytoskeleton rearrangements.
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Aepfelbacher, M., Zumbihl, R., Heesemann, J. (2005). Modulation of Rho GTPases and the Actin Cytoskeleton by YopT of Yersinia . In: Boquet, P., Lemichez, E. (eds) Bacterial Virulence Factors and Rho GTPases. Current Topics in Microbiology and Immunology, vol 291. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27511-8_9
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DOI: https://doi.org/10.1007/3-540-27511-8_9
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