Skip to main content

1-Alkylglycerophosphocholine O-acetyltransferase

  • Chapter
Springer Handbook of Enzymes

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 30))

  • 60 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lee, T.C.; Vallari, D.S.; Snyder, F.: l-Alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase. Methods Enzymol., 209, 396–401 (1992)

    Article  PubMed  CAS  Google Scholar 

  2. Gomez-Cambronero, J.; Velasco, S.; Sanchez-Crespo, M.; Vivanco, F.; Mato, J.M.: Partial purification and characterization of l-O-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase from rat spleen. Biochem. J., 237, 439–445 (1986)

    PubMed  CAS  Google Scholar 

  3. Lee, T.C.: Biosynthesis of platelet activating factor. Substrate specificity of l-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. J. Biol. Chem., 260, 10952–10955 (1985)

    PubMed  CAS  Google Scholar 

  4. Lee, T.C.; Malone, B.; Snyder, F.: A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of l-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. J. Biol. Chem., 261, 5373–5377 (1986)

    PubMed  CAS  Google Scholar 

  5. Wykle, R.L.; Malone, B.; Snyder, F.: Enzymatic synthesis of l-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid. J. Biol. Chem., 255, 10256–10260 (1980)

    PubMed  CAS  Google Scholar 

  6. Gomez-Cambronero, J.; Velasco, S.; Mato, J.M.; Sanchez-Crespo, M.: Modulation of lyso-platelet activating factor: acetyl-CoA acetyltransferase from rat splenic microsomes. The role of cyclic AMP-dependent protein kinase. Biochim. Biophys. Acta, 845, 516–519 (1985)

    Article  PubMed  CAS  Google Scholar 

  7. Ninio, E.; Joly, F.; Bessou, G.: Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance. Biochim. Biophys. Acta, 963, 288–294 (1988)

    PubMed  CAS  Google Scholar 

  8. Gomez-Cambronero, J.; Nieto, M.L.; Mato, J.M.; Sanchez-Crespo, M.: Modulation of lyso-platelet-activating factor: acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions. Biochim. Biophys. Acta, 845, 511–515 (1985)

    Article  PubMed  CAS  Google Scholar 

  9. Kume, K.; Waga, I.; Shimizu, T.: Microplate chromatography assay for acetyl-CoA:lysoplatelet-activating factor acetyltransferase. Anal. Biochem., 246, 118–122 (1997)

    Article  PubMed  CAS  Google Scholar 

  10. Roy Baker, R.; Chang, H.y.: Substrate specificities of neuronal nuclear acet-yltransferases involved in the synthesis of platelet-activating factor: Differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors. Biochim. Biophys. Acta, 1390, 215–224 (1998)

    PubMed  CAS  Google Scholar 

  11. Yamazaki, R.; Sugatani, J.; Fujii, I.; Kuroyanagi, M.; Umehara, K.; Ueno, A.; Suzuki, Y.; Miwa, M.: Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex. Biochem. Pharmacol., 47, 995–1006 (1994)

    Article  PubMed  CAS  Google Scholar 

  12. Garcia, C.; Montero, M.; Alvarez, J.; Sanchez Crespo, M.: Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid. J. Biol. Chem., 268, 4001–4008 (1993)

    PubMed  CAS  Google Scholar 

  13. Svetlov, S.I.; Liu, H.; Chao, W.; Olson, M.S.: Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. Biochim. Biophys. Acta, 1346, 120–130 (1997)

    PubMed  CAS  Google Scholar 

  14. Yanoshita, R.; Chang, H.W.; Son, K.H.; Kudo, I.; Samejina, Y.: Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm. Res., 45, 546–549 (1996)

    Article  PubMed  CAS  Google Scholar 

  15. Nagumo, S.; Fukuju, A.; Takayama, M.; Nagai, M.; Yanoshita, R.; Samejima, Y.: Inhibition of lysoPAF acetyltransferase activity by components of licorice root. Biol. Pharm. Bull., 22, 1144–1146 (1999)

    PubMed  CAS  Google Scholar 

  16. Hurst, J.S.; Bazan, H.E.P.: The sensitivity of bovine corneal epithelial lysoPAF acetyltransferase to cyclooxygenase and lipoxygenase inhibitors is independent of arachidonate metabolites. J. Ocul. Pharmacol. Ther., 13, 415–426 (1997)

    Article  PubMed  CAS  Google Scholar 

  17. Kudolo, G.B.; Yang, Y.Q.; Chen, D.B.; Jones, M.A.; Harper, M.J.K.: Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. J. Reprod. Fertil., 105, 315–324 (1995)

    Article  PubMed  CAS  Google Scholar 

  18. Ihara, Y.; Frenkel, R.A.; Johnston, J.M.: Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. Arch. Biochem. Biophys., 304, 503–507 (1993)

    Article  PubMed  CAS  Google Scholar 

  19. Baker, R.R.; Chang, H.Y.: Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. Biochim. Biophys. Acta, 1302, 257–263 (1996)

    PubMed  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2006). 1-Alkylglycerophosphocholine O-acetyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37717-4_8

Download citation

Publish with us

Policies and ethics