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Nature of Activated Bleomycin

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Metal-Oxo and Metal-Peroxo Species in Catalytic Oxidations

Part of the book series: Structure and Bonding ((STRUCTURE,volume 97))

Abstract

Activated bleomycin is the drug species seen to be kinetically competent to initiate DNA degradation in the reaction of bleomycin, Fe(II), and O2. It also forms in reactions of bleomycin with Fe(III) and peroxide, or bleomycin with superoxide and either Fe(III) or Fe(II). Efforts to characterize this transient species proceeded by kinetic and spectroscopic strategies. Activated bleomycin now appears to be a drug-ferric-peroxide complex, but this may not be the proximate active drug species. Assuming that activated bleomycin peroxide cleavage yields a reactive product analogous to peroxidase compound I explains many characteristics of bleomycin-mediated DNA degradation reactions. DNA degradation is responsible for the cytotoxic and antitumor activities of this clinically useful antibiotic.

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  1. Public Health Research Institute, 455 First Avenue, New York, NY, 10016, USA

    Richard M. Burger

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  1. Richard M. Burger
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  1. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077, Toulouse Cedex 4, France

    Bernard Meunier

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Burger, R.M. (2000). Nature of Activated Bleomycin. In: Meunier, B. (eds) Metal-Oxo and Metal-Peroxo Species in Catalytic Oxidations. Structure and Bonding, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46592-8_10

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  • DOI: https://doi.org/10.1007/3-540-46592-8_10

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