Abstract
Individuals with moderate-to-profound intellectual and developmental disabilities (IDD) are characterized by significant cognitive deficits, abnormal muscle tone, poor posture and balance, and inactive lifestyle. Increased oxidative stress (OS) has been implicated in a variety of chronic diseases, inflammatory conditions, aging, and even following intense physical exercise. Nitric oxide (NO) is a highly reactive mediator that has been shown to play different roles in a variety of different biological process and in aging. The aim of the study was to investigate the serum levels of global OS and NO metabolites (NOx) in sedentary and non-sedentary older adults with IDD. Global OS was measured by CR 3000 instrument, FORM system, and NOx were measured by determination of serum nitrite levels. OS and NOx levels were significantly higher in sedentary IDD comparing non-sedentary controls. The increased of OS and NOx levels suggest their possible involvement in the phenomenon of ‘accelerated aging’ in IDD. Our findings can provide another aspect indicating both OS and NOx as possible biochemical markers and their potential application in minimizing their negative influence through future therapeutic strategies.
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References
Andrukhov O, Haririan H, Bertl K, Rausch WD, Bantleon HP, Moritz A, Rausch-Fan X (2013) Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect. J Clin Periodontol 40(10):916–923
Baskin KK, Winders BR, Olson EN (2015) Muscle as a ‘Mediator’ of systemic metabolism. Cell Metab 21(2):237–248
Carmeli E, Merrick J, Kessel S, Masharawi Y, Carmeli V (2003) Elderly persons with intellectual disability: a study of clinical characteristics, functional status, and sensory capacity. Sci World J 3:298–307
Carmeli E, Harpaz Y, Kogan NN, Fogelman Y (2008) The effect of an endogenous antioxidant glabridin on oxidized LDL. J Basic Clin Physiol Pharmacol 19(1):49–63
Carmeli E, Beiker R, Morad M (2009) Nitric oxide and interlukin-6 levels in intellectual disability adults with epilepsy. Res Dev Disabil 30(3):567–571
Carmeli E, Merrick J, Imam B, Levy R (2012) Exercises and sports participation in healthy older adults with intellectual disability – a pilot study. Health 4(9A):769–774
Coppus AM (2013) People with intellectual disability: what do we know about adulthood and life expectancy? Dev Disabil Res Rev 18(1):6–16
Czapski GA, Cakala M, Chalimoniuk M, Gajkowska B, Strosznajder JB (2007) Role of nitric oxide in the brain during lipopolysaccharide-evoked systemic inflammation. J Neurosci Res 85:1694–1703
Dammann O, Leviton A (1998) Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol 5:190–201
Dykens EM (2013) Aging in rare intellectual disability syndromes. Dev Disabil Res Rev 18(1):75–83
Eiserich JP, Patel RP, O’Donnell VB (1998) Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules. Mol Asp Med 19(4–5):221–357
Ferrini M, Wang C, Swerdloff RS, Sinha-Hikim AP, Rajfer J, Gonzalez-Cadavid NF (2001) Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function. Neuroendocrinology 74(1):1–11
Flanagan J, Melillo KD, Abdallah L, Remington R (2007) Interpreting laboratory values in the rehabilitation setting. Rehabil Nurs 32:77–84
Floyd RA, Hensley K (2000) Nitrone inhibition of age-associated oxidative damage. Ann N Y Acad Sci 899:222–237
Floyd RA, Hensley K, Bing G (2000) Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics. J Neural Transm Suppl 60:387–414
Garcez ME, Peres W, Salvador M (2005) Oxidative stress and hematologic and biochemical parameters in individuals with Down syndrome. Mayo Clin Proc 80(12):1607–1611
Grisham MB, Jourd’Heuil D, Wink DA (1999) Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol 276(2 Pt 1):G315–G321
Hays JR, Reas DL, Shaw JB (2002) Concurrent validity of the Wechsler abbreviated scale of intelligence and the Kaufman brief intelligence test among psychiatric inpatients. Psychol Rep 90:355–359
Heller T, Sorensen A (2013) Promoting healthy aging in adults with developmental disabilities. Dev Disabil Res Rev 18(1):22–30
Krause KH (2007) Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 42(4):256–262
Lawler JM, Hindle A (2011) Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia. Antioxid Redox Signal 15(9):2529–2541
Mangge H, Becker K, Fuchs D, Gostner JM (2014) Antioxidants, inflammation and cardiovascular disease. World J Cardiol 6(6):462–477
Mehanna C, Baudouin C, Brignole-Baudouin F (2011) Spectrofluorometry assays for oxidative stress and apoptosis, with cell viability on the same microplates: a multiparametric analysis and quality control. Toxicol in Vitro 25(5):1089–1096
Merrick J, Kandel I, Stawski M (2006) Trends in mental health services for people with intellectual disability in residential care in Israel 1998–2004. Isreal J Psychiatry Relat Sci 43:281–284
Nyberg M, Blackwell JR, Damsgaard R, Jones AM, Hellsten Y, Mortensen SP (2012) Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. J Physiol 590(Pt 21):5361–5370
Pedersen BK (2009) The diseasome of physical inactivity-and the role of myokines in muscle-fat cross talk. J Physiol 587(Pt 23):5559–5568
Russ DW, Lanza IR (2011) The impact of old age on skeletal muscle energetics: supply and demand. Curr Aging Sci 4(3):234–247
Saltin B (2007) Exercise hyperaemia: magnitude and aspects on regulation in humans. J Physiol 583(Pt 3):819–823
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84
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Carmeli, E., Bachar, A., Rom, O., Aizenbud, D. (2015). Oxidative Stress and Nitric Oxide in Sedentary Older Adults with Intellectual and Developmental Disabilities. In: Pokorski, M. (eds) Pathophysiology of Respiration. Advances in Experimental Medicine and Biology(), vol 884. Springer, Cham. https://doi.org/10.1007/5584_2015_166
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DOI: https://doi.org/10.1007/5584_2015_166
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