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fMRI as a Measure of Cognition Related Brain Circuitry in Schizophrenia

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Brain Imaging in Behavioral Neuroscience

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 11))

Abstract

Functional magnetic resonance imaging (fMRI) has played a prominent role in the quest to identify the brain systems responsible for cognitive dysfunction in schizophrenia. This chapter describes the evolution of these research efforts, which have alternated between efforts to localize specific cognitive impairments to work trying to understand broader network dysfunction. After a concise summary of localization efforts, the remainder of the chapter describes how different groups of scientists have developed and tested broader network theories. This includes a description of both task-activation and resting state studies, and involves a wide array of analytic techniques. The chapter closes with an understanding of how current default-mode and task-positive network theories grew out of these earlier resting-state and task-activation approaches, and provides some recommendations about future directions.

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Acknowledgments

This work was supported by NIMH grant R01MH084895.

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Authors and Affiliations

  1. Departments of Psychology and Psychiatry, University of California at Davis, Davis, CA, USA

    Laura A. Libby & J. Daniel Ragland

Authors
  1. Laura A. Libby
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  2. J. Daniel Ragland
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Editors and Affiliations

  1. , UC Davis Imaging Center, University of California at Davis, X Street 4701, Sacramento, 95817, California, USA

    Cameron S. Carter

  2. , Dep of Experimental Psychology/Dep of Ps, University of Cambridge, Downing Site, Cambridge, CB2 3EB, United Kingdom

    Jeffrey W. Dalley

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© 2011 Springer-Verlag Berlin Heidelberg

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Libby, L.A., Ragland, J.D. (2011). fMRI as a Measure of Cognition Related Brain Circuitry in Schizophrenia. In: Carter, C., Dalley, J. (eds) Brain Imaging in Behavioral Neuroscience. Current Topics in Behavioral Neurosciences, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_173

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