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Phosphoinositide Lipids and the Legionella Pathogen Vacuole

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Molecular Mechanisms in Legionella Pathogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 376))

Abstract

Subversion of vesicle trafficking is vital for intracellular survival of Legionella pneumophila within host cells. L. pneumophila produces several type IV-translocated effector proteins that modify components of the phagosomal membrane, in particular the phosphoinositide (PI) lipids. Within eukaryotic cells PIs co-define subcellular compartments and membrane dynamics. The generation, half-life, and localization of PI lipids are not only tightly regulated by the host cell, but also targeted and modulated by a number of L. pneumophila effectors. These effectors either anchor to PIs, directly modify the lipids, or recruit PI-metabolizing enzymes to the LCV membrane. Together, PI-subverting L. pneumophila effectors act jointly to promote the formation of a replication-permissive niche inside the host.

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Abbreviations

AMPylase:

Adenylyltransferase

ANTH domain:

AP180 N-terminal homology domain

DAG:

Diacylglycerol

ENTH domain:

Epsin N-terminal homology domain

ER:

Endoplasmic reticulum

FYVE domain:

Domain occurring in Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1

GDF:

GDI displacement factor

GDI:

Guanine nucleotide dissociation inhibitor

GEF:

Guanine nucleotide exchange factor

LCV:

Legionella-containing vacuole

LVA domain:

Legionella vacuole association domain

MVB:

Multivesicular body

PH domain:

Pleckstrin homology domain

PHOX domain:

Phagocyte NADPH oxidase domain

PI:

Phosphoinositide

PI3K:

Phosphoinositide 3-kinase

PtdIns:

Phosphatidylinositol

PX domain:

PHOX homology domain

SCV:

Salmonella-containing vacuole

T2SS:

Type II secretion system

T4SS:

Type IV secretion system

TGN:

Trans-Golgi network

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  1. Medical Faculty, Max von Pettenkofer Institute, Ludwig-Maximilians University, Munich Pettenkoferstrasse 9a, 80336, Munich, Germany

    Ina Haneburger & Hubert Hilbi

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  1. Ina Haneburger
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  2. Hubert Hilbi
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  1. Max von Pettenkofer Institute, Ludwig-Maximilians University München, Munich, Germany

    Hubert Hilbi

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Haneburger, I., Hilbi, H. (2013). Phosphoinositide Lipids and the Legionella Pathogen Vacuole. In: Hilbi, H. (eds) Molecular Mechanisms in Legionella Pathogenesis. Current Topics in Microbiology and Immunology, vol 376. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_341

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