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The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity

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Transcriptional Control of Lineage Differentiation in Immune Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 381))

Abstract

The proper regulation of the development and function of peripheral helper and cytotoxic T cell lineages is essential for T cell-mediated adaptive immunity. Progress made during the last 10–15 years led to the identification of several transcription factors and transcription factor networks that control the development and function of T cell subsets. Among the transcription factors identified are also several members of the so-called BTB/POZ domain containing zinc finger (ZF) transcription factor family (BTB-ZF), and important roles of BTB-ZF factors have been described. In this review, we will provide an up-to-date overview about the role of BTB-ZF factors during T cell development and in peripheral T cells.

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Acknowledgments

The work in the laboratory of W.E. is supported by the Austrian Science Fund (FWF) projects P23641FW and P26193FW, and by the FWF/Meduni Vienna doctoral program (W1212) “Inflammation and Immunity.”

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Authors and Affiliations

  1. Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria

    Wilfried Ellmeier

  2. Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan

    Ichiro Taniuchi

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  1. Wilfried Ellmeier
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Correspondence to Wilfried Ellmeier .

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  1. Medical University of Vienna, Division of Immunobiology, Institute of Immunology, Center of Pathophysiology,Infectiology and Immunology, Vienna, Wien, Austria

    Wilfried Ellmeier

  2. RIKEN Center for Integrative Medical Sciences, IMS,, Laboratory for Transcriptional Regulation,, Yokohama, Kanagawa, Japan

    Ichiro Taniuchi

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Ellmeier, W., Taniuchi, I. (2014). The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity. In: Ellmeier, W., Taniuchi, I. (eds) Transcriptional Control of Lineage Differentiation in Immune Cells. Current Topics in Microbiology and Immunology, vol 381. Springer, Cham. https://doi.org/10.1007/82_2014_374

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