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Getting to Know Viral Evolutionary Strategies: Towards the Next Generation of Quasispecies Models

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Quasispecies: From Theory to Experimental Systems

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 392))

Abstract

Viral populations are formed by complex ensembles of genomes with broad phenotypic diversity. The adaptive strategies deployed by these ensembles are multiple and often cannot be predicted a priori. Our understanding of viral dynamics is mostly based on two kinds of empirical approaches: one directed towards characterizing molecular changes underlying fitness changes and another focused on population-level responses. Simultaneously, theoretical efforts are directed towards developing a formal picture of viral evolution by means of more realistic fitness landscapes and reliable population dynamics models. New technologies, chiefly the use of next-generation sequencing and related tools, are opening avenues connecting the molecular and the population levels. In the near future, we hope to be witnesses of an integration of these still decoupled approaches, leading into more accurate and realistic quasispecies models able to capture robust generalities and endowed with a satisfactory predictive power.

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Acknowledgments

The authors acknowledge support of the Spanish MINECO through projects BFU2013-41329, FIS2011-27569, and FIS2014-57686.

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Authors and Affiliations

  1. Centro Nacional de Biotecnología (CSIC), c/Darwin 3, 28049, Madrid, Spain

    Susanna Manrubia

  2. Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain

    Susanna Manrubia & Ester Lázaro

  3. Centro de Astrobiología (INTA-CSIC), Ctra. de Ajalvir km. 4, 28850 Torrejón de Ardoz, Madrid, Spain

    Ester Lázaro

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  1. Susanna Manrubia
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Correspondence to Susanna Manrubia .

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  1. Campus de Cantoblanco, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

    Esteban Domingo

  2. The Santa Fe Institute, Santa Fe, NM, USA and Institut f. Theoretische Chemie, Universität Wien, Vienna, Austria

    Peter Schuster

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Manrubia, S., Lázaro, E. (2015). Getting to Know Viral Evolutionary Strategies: Towards the Next Generation of Quasispecies Models. In: Domingo, E., Schuster, P. (eds) Quasispecies: From Theory to Experimental Systems. Current Topics in Microbiology and Immunology, vol 392. Springer, Cham. https://doi.org/10.1007/82_2015_457

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