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GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis

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The Fungal Cell Wall

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 425))

Abstract

Glycosylphosphatidylinositol (GPI) anchored proteins are a class of proteins attached to the extracellular leaflet of the plasma membrane via a post-translational modification, the glycolipid anchor. GPI anchored proteins are expressed in all eukaryotes, from fungi to plants and animals. They display very diverse functions ranging from enzymatic activity, signaling, cell adhesion, cell wall metabolism, and immune response. In this review, we investigated for the first time an exhaustive list of all the GPI anchored proteins present in the Aspergillus fumigatus genome. An A. fumigatus mutant library of all the genes that encode in silico identified GPI anchored proteins has been constructed and the phenotypic analysis of all these mutants has been characterized including their growth, conidial viability or morphology, adhesion and the ability to form biofilms. We showed the presence of different fungal categories of GPI anchored proteins in the A. fumigatus genome associated to their role in cell wall remodeling, adhesion, and biofilm formation.

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Acknowledgements

This research was funded by l’Agence Nationale pour la Recherche (AfuInf ANR-16-CE92-0039), la Fondation pour la Recherche Médicale (DEQ 20150331722 LATGE Equipe FRM 2015) and the AIC (Action Incitative Ciblée) grant of Pasteur Institute. This work was also supported by the Wellcome trust grant 208396/Z/17/Z to MB.

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Authors and Affiliations

  1. Aspergillus Unit, Institut Pasteur, 25 Rue Du Docteur Roux, 75015, Paris, France

    Marketa Samalova, Michael Blatzer, Jean-Paul Latgé & Isabelle Mouyna

  2. Division of Infection, Immunity and Respiratory Medicine, Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Paul Carr & Mike Bromley

  3. Unité Technologie et Service Bioimagerie Ultrastructurale (UTechS UBI), Institut Pasteur, 28 Rue Du Docteur Roux, 75015, Paris, France

    Maryse Moya-Nilges

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  1. Marketa Samalova
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  2. Paul Carr
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  3. Mike Bromley
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  6. Jean-Paul Latgé
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Correspondence to Isabelle Mouyna .

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  1. Foundation for Research and Technology-Hellas (FORTH), Institute of Molecular Biology and Technology, Heraklion, Crete, Greece

    Jean-Paul Latgé

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Samalova, M. et al. (2020). GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis. In: Latgé, JP. (eds) The Fungal Cell Wall . Current Topics in Microbiology and Immunology, vol 425. Springer, Cham. https://doi.org/10.1007/82_2020_207

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