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Synthesis of Novel Chain Extended and Crosslinked Polylactones for Tissue Regeneration and Controlled Release Applications

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Active Implants and Scaffolds for Tissue Regeneration

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 8))

Abstract

In addition to ring opening homo- and co-polymerization, chain extension and crosslinking are attractive routes for synthesizing polylactones. Through manipulation of molecular composition and molecular architecture a wide range of mechanical, thermal and degradation properties can be achieved, and using different coupling chemistries, polylactones belonging to many kinds of linear and network-structured polymer families have been synthesized. The poly(ester-urethanes), poly(ester-amides), poly(ester-urethane-amides), polyphosphoesters, poly(ester-anhydrides) and methacrylated crosslinking polyesters polymer families have great potential in biomedical applications such as surgery, tissue-engineering, and controlled active agent release. Mechanical properties, degradation characteristics and rate, and release properties of these polymers can be adjusted within wide ranges. Biopolymers showing bone-like hardness or soft non-creeping elasticity have been synthesized. Poly(ester-anhydrides) in particular combine useful properties of polyesters and polyanhydrides, and have been shown to degrade by surface-erosion, enabling controlled macromolecular active agent release. Photocuring of liquid pre-polymers enables the use of biopolymers in high precision lithographic techniques like micromolding in capillaries, stereolithography and two-photon polymerization. This makes it possible to design and customize complicated scaffold structures, with desired drug release profiles for various biomedical applications.

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Authors and Affiliations

  1. Polymer Technology Research Group, Department of Biotechnology and Chemical Technology, School of Science and Technology, Aalto University, P.O. Box 16100, 00076, Aalto, Finland

    Jukka Seppälä, Harri Korhonen, Risto Hakala & Minna Malin

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  1. Jukka Seppälä
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  2. Harri Korhonen
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  3. Risto Hakala
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  4. Minna Malin
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Correspondence to Jukka Seppälä .

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  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Tel Aviv, 69978, Israel

    Meital Zilberman

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Seppälä, J., Korhonen, H., Hakala, R., Malin, M. (2011). Synthesis of Novel Chain Extended and Crosslinked Polylactones for Tissue Regeneration and Controlled Release Applications. In: Zilberman, M. (eds) Active Implants and Scaffolds for Tissue Regeneration. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_52

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