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References

  1. Lee A(1985) Neglected niches. The microbial ecology of the gastro-intestinal tract. Adv Microb Ecol 8: 115–162

    Google Scholar 

  2. Savage DC (1977) Microbial ecology of the gastro-intestinal tract. Annu Rev Microbiol 3:107–133

    Article  Google Scholar 

  3. Stephen A, Cummings J (1980) The microbial constitution of human faecal mass. J Med Microbiol 13: 45–51

    PubMed  CAS  Google Scholar 

  4. Mobbs K, van Saene HKF, Sunderland D, Davies PDO (1999) Oropharyngeal Gram-negative bacillary carriage. A survey in 120 healthy individuals. Chest 115:1570–1575

    Article  PubMed  CAS  Google Scholar 

  5. Savage DC (1979) Introduction to mechanisms of association of indigenous microbes. Am J Clin Nutr 32: 113–118

    PubMed  CAS  Google Scholar 

  6. Vantrappen G, Janssens J, Hellemans J, Ghoos Y (1977) The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166

    PubMed  CAS  Google Scholar 

  7. Husebye E (1995) Gastrointestinal motility disorders and bacterial overgrowth. J Intern Med 237: 419–427

    Article  PubMed  CAS  Google Scholar 

  8. Walker H, Durie K et al (2000) Pediatric gastro-intestinal diseases, 3rd edn. Decker

    Google Scholar 

  9. Giannella RA, Broitman SA, Zamsheck N (1972) Gastric-acid barrier to ingested micro-organisms in man: studies in vivo and in vitro. Gut 13:251–256

    PubMed  CAS  Google Scholar 

  10. Stannard VA, Hutchinson A, Morris DL, Byrne A (1988) Gastric exocrine failure in critically ill patients: incidence and associated features. BMJ 296:155–156

    Article  PubMed  CAS  Google Scholar 

  11. Hillman KM, Riordan T, O’Farrell SM, Tabaqchali S (1982) Colonization of the gastric content in critically ill patients. Crit Care Med 10:444–447

    PubMed  CAS  Google Scholar 

  12. Thorens J, Froelich F et al (1996) Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 39:54–59

    PubMed  CAS  Google Scholar 

  13. Howden CW, Hunt RH (1987) Relationship between gastric secretion and infection. Gut 28:96–107

    PubMed  CAS  Google Scholar 

  14. Peterson WL, Mackowiak PA, Barnett CC et al (1989) The human gastric bactericidal barrier. J Infect Dis 159:979–983

    PubMed  CAS  Google Scholar 

  15. Proctor RA (1987) Fibronectin: a brief overview of its structure, function and physiology. Rev Infect Dis 9:S317–S321

    PubMed  CAS  Google Scholar 

  16. Dal Nogare AR, Toews GB, Pierce AK (1987) Increased salivary elastase precedes Gram-negative bacillary colonisation in post-operative patients. Am Rev Respir Dis 135:671–675

    Google Scholar 

  17. Mobbs KJ, van Saene HKF, Sunderland D, Davies PDO (1999) Oropharyngeal Gram-negative bacillary carriage in chronic obstructive pulmonary disease: relation to severity of disease. Respir Med 93:540–545

    Article  PubMed  CAS  Google Scholar 

  18. Clamp JR (1984) The relationship between the immune system and mucus in the protection of mucous membranes. Biochem Soc Trans 12:754–756

    PubMed  CAS  Google Scholar 

  19. Balistreri WF, Bove KE (1990) Hepatobiliary consequences of parenteral alimentation. Prog Liver Dis 9: 567–601

    PubMed  CAS  Google Scholar 

  20. Pierro A, van Saene HKF, Jones MO, Nunn et al (1998) Clinical impact of abnormal gut flora in infants receiving parenteral nutrition. Ann Surg 227:547–552

    Article  PubMed  CAS  Google Scholar 

  21. Libosni Y, Nezu R, Kennedy M et al (1994) Total parenteral nutrition decreases luminal mucous gel and intestinal permeability of small intestine. J Parenter Enteral Nutr 18:346–350

    Article  Google Scholar 

  22. Katayama M, Xu D, Specian RD, Deitch EA (1997) Role of bacterial adherence and the mucus barrier on bacterial translocation. Ann Surg 225:317–326

    Article  PubMed  CAS  Google Scholar 

  23. Bosscha K, Nieuwenhuijs VB, Vos A et al (1998) Gastrointestinal motility and gastric tube feeding in mechanically ventilated patients. Crit Care Med 26:1510–1517

    Article  PubMed  CAS  Google Scholar 

  24. Holte K, Kehlet H (2000) Postoperative ileus: a preventable event. Br J Surg 87:1480–1493

    Article  PubMed  CAS  Google Scholar 

  25. Donnell SC, Taylor N, van Saene HKF et al (2002) Infection rates in surgical neonates and infants receiving parenteral nutrition: a five-year prospective study. J Hosp Infect 52:273–280

    Article  PubMed  CAS  Google Scholar 

  26. Zietz B, Lock G, Straub RH et al (2000) Small-bowel bacterial overgrowth in diabetic subjects is associated with cardiovascular autonomic neuropathy. Diabetes Care 23:1200–1201

    PubMed  CAS  Google Scholar 

  27. Skar V, Skar AG, Osnes M (1989) The duodenal flora in the region of papilla of Vater in patients with and without duodenal diverticula. Scand J Gastroenterol 24:649–656

    PubMed  CAS  Google Scholar 

  28. Ikeda H, Suzuki Y, Koike M et al (1998) Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 42:530–537

    Article  PubMed  CAS  Google Scholar 

  29. Sasaki M, Fitzgerald AJ, Grant G et al (2002) Lectins can reverse the distal atrophy associated with elemental diets in mice. Aliment Pharmacol Ther 16:633–642

    Article  PubMed  CAS  Google Scholar 

  30. Leblond CP, Walker BE (1956) Absorption. Physiol Rev 36:255–290

    PubMed  CAS  Google Scholar 

  31. Gordon HA, Bruckner-Kardoss E (1961) Effect of normal microbial flora on intestinal surface area. Am J Physiol 201:175–178

    PubMed  CAS  Google Scholar 

  32. Targan SR, Kognoff MF, Brogan MD et al (1987) Immunologic mechanisms in intestinal diseases. Ann Intern Med 106:853–870

    PubMed  CAS  Google Scholar 

  33. MacDonald TT (2001) Introduction. Semin Immunol 13:159–161

    Article  PubMed  CAS  Google Scholar 

  34. Conley ME, Delacroix DL (1987) Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense? Ann Intern Med 106:892–899

    PubMed  CAS  Google Scholar 

  35. Mestecky J, Russell M, Elson CO (1999) Intestinal IgA, novel views on its function in the defence of the largest mucosal surface. Gut 44:2–5

    Article  PubMed  CAS  Google Scholar 

  36. van Saene HKF, Zandstra DF (2004) Selective decontamination of the digestive tract: rationale behind evidence-based use in liver transplantation. Liver Transpl 10:828–833

    Article  PubMed  Google Scholar 

  37. van Saene HKF, Damjanovic V, Alcock SR (2001) Basics in microbiology for the patient requiring intensive care. Curr Anaesth Crit Care 12:6–17

    Article  Google Scholar 

  38. Mackowiak PA, Martin RM, Jones SR et al (1978) Pharyngeal colonisation by gram-negative bacilli in aspiration-prone persons. Arch Intern Med 138:1224–1227

    Article  PubMed  CAS  Google Scholar 

  39. Fuxench-Lopez Z, Ramirez-Ronda CH (1978) Pharyngeal flora in ambulatory alcoholic patients: prevalence of gram-negative bacilli. Arch Intern Med 138:1815–1816

    Article  PubMed  CAS  Google Scholar 

  40. Kerver AJH, Rommes JH, Mevissen-Verhage EAE et al (1988) Prevention of colonization and infection in critically ill patients: a prospective randomized study. Crit Care Med 16:1087–1093

    PubMed  CAS  Google Scholar 

  41. Sanchez Garcia M, Cambronero Galache JA, Lopez Diaz J et al (1998) Effectiveness and cost of selective decontamination of the digestive tract in critically ill intubated patients. Am J Respir Crit Care Med 158: 908–916

    PubMed  CAS  Google Scholar 

  42. Ketai LH, Rypka G (1993) The course of nosocomial oropharyngeal colonisation in patients recovering from acute respiratory failure. Chest 103:1837–1841

    PubMed  CAS  Google Scholar 

  43. Kerver AJH, Rommes JH, Mevissen-Verhage EAE et al (1987) Colonization and infection in surgical intensive care patients: a prospective study. Intensive Care Med 13:347–351

    Article  PubMed  CAS  Google Scholar 

  44. Luiten EJT, Hop WCJ, Endtz HP, Bruining HA (1998) Prognostic importance of gram-negative intestinal colonization preceding pancreatic infection in severe acute pancreatitis. Intensive Care Med 24:438–445

    Article  PubMed  CAS  Google Scholar 

  45. Luiten EJT, Hop WCJ, Lange JF, Bruining HA (1995) Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann Surg 222:57–65

    PubMed  CAS  Google Scholar 

  46. Flynn DM, Weinstein RA, Nathan C, Gaston MA, Kabins SA (1987) Patients’ endogenous flora as the source of “nosocomial” Enterobacter in cardiac surgery. J Infect Dis 156:363–368

    PubMed  CAS  Google Scholar 

  47. Garrouste-Orgeas M, Marie O, Rouveau M, Villiers S, Arlet G, Schlemmer B (1996) Secondary carriage with multi-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an adult population: relationship with nosocomial infections and mortality. J Hosp Infect 34:279–289

    Article  PubMed  CAS  Google Scholar 

  48. Sveen K, Hofstad T, Milner KC (1977) Lethality for mice and chick embryos, pyogenicity in rabbits and ability to gelate lysate from amoebocytes of Limulus polyphemus by polysaccharides from Bacteroides, Fusobacterium and Veillonella. Acta Pathol Microbiol Scand 85:388–3986

    Google Scholar 

  49. Simon GL, Gelfland JA, Conolly RA et al (1985) Experimental Bacteroides fragilis bacteremia in a primate model: evidence that Bacteroides fragilis does not promote the septic shock syndrome. J Trauma 25: 1156–1162

    PubMed  CAS  Google Scholar 

  50. Maier RV, Hahnnel GB, Pohlman TH (1990) Endotoxin requirements or alveolar macrophage stimulation. J Trauma 30[Suppl 2]:S49–S57

    PubMed  CAS  Google Scholar 

  51. Magnuson DK, Weintraub A, Pohlman TH, Maier RV (1989) Human endothelial cell adhesiveness for neutrophils, induced by E. coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccahride. J Immunol 143:3025–3030

    PubMed  CAS  Google Scholar 

  52. Leenstra TS, van Saene JJM, van Saene HKF et al (1996) Oral endotoxin in healthy adults. Oral Surg Oral Med Oral Pathol 82:637–643

    CAS  Google Scholar 

  53. van Saene JJM, Stoutenbeek CP, van Saene HKF (1992) Faecal endotoxin in human volunteers: normal values. Microb Ecol Health Dis 5:179–184

    Article  Google Scholar 

  54. van Saene HKF, Stoutenbeek CP, Faber-Nijholt R, van Saene JJM (1992) Selective decontamination of the digestive tract contributes to the control of disseminated intravascular coagulation in severe liver impairment. J Pediatr Gastroenterol Nutr 14:436–442

    PubMed  Google Scholar 

  55. Rombeau JL, Takala (1997) Gut dysfunction in critical illness. Intensive Care Med 23:476–479

    Article  PubMed  CAS  Google Scholar 

  56. Sheth K, Bankey P (2001) The liver as an immune organ. Curr Opin Crit Care 7:99–104

    Article  PubMed  CAS  Google Scholar 

  57. Das J, Schwartz AA, Folkman J (1973) Clearance of endotoxin by platelets: role in increasing the accuracy of the Limulus gelation test and in combatting experimental endotoxemia. Surgery 74:235–240

    PubMed  CAS  Google Scholar 

  58. Quesenberry P, Morley A, Stohlman F et al (1972) Effect of endotoxin on granulopoiesis and colony stimulating factor. N Engl J Med 286:227–232

    Article  PubMed  CAS  Google Scholar 

  59. Wigg AJ, Roberts-Thomson IC, Dymock RB et al (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumor necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206–211

    Article  PubMed  CAS  Google Scholar 

  60. Marshall JC, Christou NV, Meakins JL (1988) Small-bowel bacterial overgrowth and systemic immunosuppression in experimental peritonitis. Surgery 104:404–411

    PubMed  CAS  Google Scholar 

  61. Schweinburg FB, Seligman AM, Fine J (1950) Transmural migration of intestinal bacteria. N Engl J Med 242:747–751

    Article  PubMed  CAS  Google Scholar 

  62. Feltis BA, Wells CL (2000) Does microbial translocation play a role in critical illness? Curr Opin Crit Care 6:117–122

    Article  Google Scholar 

  63. Brathwaite CEM, Ross SE, Nagole R et al (1993) Bacterial translocation occurs in humans after traumatic injury: evidence using immunofluorescence. J Trauma 34:586–590

    PubMed  CAS  Google Scholar 

  64. Kane TD, Wesley Alexander J, Johannigman JA (1998) The detection of microbial DNA in the blood. Ann Surg 227:1–19

    Article  PubMed  CAS  Google Scholar 

  65. Lichtman SN, Sartor RB, Keku J, Schwab JH (1990) Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth. Gastroenterology 93:234–237

    Google Scholar 

  66. Riordan SM, McIver CJ, Williams R (1998) Liver damage in human small intestinal bacterial overgrowth. Am J Gastroenterol 93:234–237

    Article  PubMed  CAS  Google Scholar 

  67. Nolan JP (1989) Intestinal endotoxins as mediators of hepatic injury—an idea whose time has come again. Hepatology 10:234–237

    Google Scholar 

  68. Pappo I, Becovier H, Berry EM et al (1991) Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during parenteral nutrition in the rat. J Surg Res 51:106–112

    Article  PubMed  CAS  Google Scholar 

  69. Deitch E, Xu D, Lu Q, Berg R (1991) Bacterial translocation from the gut impairs systemic immunity. Surgery 104:269–276

    Google Scholar 

  70. Mason C, Dobard E, Summer W et al (1997) Intraportal lipopolysaccharide suppress pulmonary antibacterial defense mechanisms. J Infect Dis 176:1293–1302

    Article  PubMed  CAS  Google Scholar 

  71. Nathens AB, Rotstein OR, Dackiw APB, Marshall JC (1995) Intestinal epithelial cells down-regulate macrophage tumor necrosis factor-alpha secretion: a mechanism for immune homeostasis in the gut associated lymphoid tissue. Surgery 118:343–351

    Article  PubMed  CAS  Google Scholar 

  72. Sondheimer JM, Asturias E, Cadnapaphornchai M (1998) Infection and cholestasis in neonates with intestinal resection and long-term parenteral nutrition. J Pediatr Gastroenterol Nutr 27:131–137

    Article  PubMed  CAS  Google Scholar 

  73. van Saene HKF, Taylor N, Donnell SC et al (2003) Gut overgrowth of abnormal flora: the missing link in parenteral nutrition-related sepsis in surgical neonates. Eur J Clin Nutr 57:548–553

    Article  PubMed  Google Scholar 

  74. Alverdy JC, Burke D (1992) Total parenteral nutrition: iatrogenic immunosuppression. Nutrition 8: 359–365

    PubMed  CAS  Google Scholar 

  75. Fong Y, Marano MA, Barber A et al (1989) Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in humans. Ann Surg 210:449–457

    PubMed  CAS  Google Scholar 

  76. Moore FA, Moore EE, Jones TN et al (1989) TEN versus TPN following major abdominal trauma—reduced septic morbidity. J Trauma 29:916–923

    Article  PubMed  CAS  Google Scholar 

  77. van Saene HKF, Percival A (1991) Bowel micro-organisms—a target for selective antimicrobial control. J Hosp Infect 19[Suppl C:19–41

    PubMed  Google Scholar 

  78. Petros AJ, O’Connell, Roberts C et al (2001) Systemic antibiotics fail to clear multi-resistant Klebsiella from a pediatric ICU. Chest 119:862–866

    Article  PubMed  CAS  Google Scholar 

  79. Damjanovic V, Connelly CM, van Saene HKF et al (1993) Selective decontamination with nystatin for control of a Candida outbreak in a neonatal intensive care unit. J Hosp Infect 24:245–249

    Article  PubMed  CAS  Google Scholar 

  80. Modi V, Damjanovic V, Cooke RWI (1987) Outbreak of cephalosporin-resistant Enterobacter cloacae infection in a neonatal intensive care unit. Arch Dis Child 62:148–151

    PubMed  CAS  Google Scholar 

  81. Toltzis P, Yamashita T, Vilt L et al (1998) Antibiotic restriction does not alter endemic colonization with resistant Gram-negative rods in a pediatric intensive care unit. Crit Care Med 26:1893–1899

    PubMed  CAS  Google Scholar 

  82. Silvestri L, Milanese M, Oblach L et al (2002) Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients. Am J Infect Control 30:391–399

    Article  PubMed  Google Scholar 

  83. Baxby D, Saene HKF van, Stoutenbeek CP, Zandstra DF (1996) Selective decontamination of the digestive tract: 13 years on, what it is and what it is not. Intensive Care Med 22:699–706

    PubMed  CAS  Google Scholar 

  84. Yao YM, Lu LR, Yu Y et al (1997) Influence of selective decontamination of the digestive tract on cell-mediated immune function and bacteria-endotoxin translocation in thermally injured rats. J Trauma 42:1073–1079

    Article  PubMed  CAS  Google Scholar 

  85. Artenstein AW, Cross AS (1989) Inhibition of endotoxin reactivity by aminoglycosides. J Antimicrob Chemother 24:826–828

    PubMed  CAS  Google Scholar 

  86. Crosby HA, Bion JF, Penn CW, Elliott TSJ (1994) Antibiotic-induced release of endotoxin from bacteria in-vitro. J Med Microbiol 40:23–30

    Article  PubMed  CAS  Google Scholar 

  87. Rifkind D (1967) Pevention by polymyxin B of endotoxin lethality in mice. J Bacteriol 93:1463–1464

    PubMed  CAS  Google Scholar 

  88. Foca A, Matera G, Ianello D et al (1991) Aminoglycosides modify the in-vitro metachromatic reactions and murine generalized Shwartzman phenomenon induced by Salmonella minnesota R595 lipopolysaccharide. Antimicrob Agents Chemother 35:2161–2164

    PubMed  CAS  Google Scholar 

  89. Rosman C, Wubbels GF, Manson LW, Bleichrodt RP (1992) Selective decontamination of the digestive tract prevents secondary infections of the abdominal cavity, and endotoxemia and mortality in sterile peritonitis in laboratory rats. Crit Care Med 20:1699–1704

    PubMed  CAS  Google Scholar 

  90. van Saene JJM, Stoutenbeek CP, van Saene HKF, Matera G, Martinez-Pellus AE, Ramsay G (1996) Reduction of the intestinal endotoxin pool by three different SDD regimens in human volunteers. J Endotoxin Res 3: 337–343

    Google Scholar 

  91. Conraads VM, Jorens PG, de Clerck LS et al (2004) Selective intestinal decontamination in advanced chronic heart failure: a pilot trial. Eur J Heart Fail 6:483–491

    Article  PubMed  CAS  Google Scholar 

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Rosseneu, S., Rios, G., Spronk, P., van Saene, J. (2005). Carriage. In: van Saene, H.K.F., De La Cal, M.A., Silvestri, L. (eds) Infection Control in the Intensive Care Unit. Topics in Anaesthesia and Critical Care. Springer, Milano . https://doi.org/10.1007/88-470-0361-X_2

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