Skip to main content

Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India

  • Chapter
Hormonal Carcinogenesis V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 617))

Summary

Residuesof organochlorine pesticides are integral part of our environment.Because of their strong lipophilic and non-biodegradable nature, organisms at higher trophic levels in the food chain tend to accumulate them. The aim of the present study was to assess the influence of organochlorine pesticides upon the occurrence of reproductive tract cancers in women from Jaipur, India. Blood samples were collected from 150 females. In that group, 100 females suffered from reproductive tract cancers like cervical, uterine, vaginal and ovarian cancers, while the rest did not suffer from cancers or any other major disease and were treated as control group. The collected blood samples were subjected to pesticide extraction and analyzed with the help of gas chromatography. The pesticides detected were benzene hexa chlororide and its isomers, dieldrin, heptachlor, dichloro diphenyl trichloro ethane and its metabolites. The data obtained indicate that the organochlorine pesticide residue levels were significantly higher in all the cancer patients as compared with the control group.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Falck F, Ricci A, Wolff MS, et al. (1992) Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 47:143–146.

    PubMed  Google Scholar 

  2. Colborn T, Vom Saal FS, Sole AM (1993) Developmental Effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378–384.

    Article  PubMed  CAS  Google Scholar 

  3. Turner KJ and Sharpe RM (1997) Environmental oestrogens – Present understanding. Rev Reprod 2:69–73.

    Article  PubMed  CAS  Google Scholar 

  4. Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal diethylstilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881.

    PubMed  CAS  Google Scholar 

  5. Tiemann U, Schneider F, Tuchscherer A (1996). Effects of ornganochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol 70:490–496.

    Article  PubMed  CAS  Google Scholar 

  6. Arnold SF, Klotz DM, Collins BM, et al. (1996) Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272:1489–1492.

    Article  PubMed  CAS  Google Scholar 

  7. Bush B, Snow J, Koblintz R (1984) Polychlorobiphenyl (PCB) congeners p,p'-DDE and hexachlorobenzene in maternal and fetal cord blood from mothrs inupstate. New York. Arch Environ Contam Toxicol 13:517–527.

    Article  PubMed  CAS  Google Scholar 

  8. Agarwal, A (2000): Contaminated wheat. Down to Earth, Aug. 31. 22.

    Google Scholar 

  9. Nair A, Pillai MKK (1992) Trends in ambient levels of DDT and HCH residues in human and the environment of Delhi, India. The Sci Total Environ 121:145–157.

    Article  CAS  Google Scholar 

  10. Patlak M (1996) Estrogens may link pesticides. Breast Cancer Environ Sci Tech News 30(5):210A–211A.

    CAS  Google Scholar 

  11. Davis DL, Bradlow HL, Wolff M, et al. Medical hypothesis: Xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 101(5):372.

    Google Scholar 

  12. Golden RJ, Noller KL, Ernstoff LT, et al. (1998) Environmental endocrine modualators and human health: an Assessment of the biological evidence. Crit Rev Toxicol 28(2):109–227.

    Article  PubMed  CAS  Google Scholar 

  13. Harris JR, Lippman ME, Veronesi V (1992). Breast cancer, Part 1 of 3, New Eng J Med 319–327.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer

About this chapter

Cite this chapter

Mathur, V., John, P.J., Soni, I., Bhatnagar, P. (2008). Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India. In: Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T. (eds) Hormonal Carcinogenesis V. Advances in Experimental Medicine and Biology, vol 617. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69080-3_37

Download citation

Publish with us

Policies and ethics