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Hereditary aspects of respiratory control in health and disease in humans

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Genetic Basis for Respiratory Control Disorders

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References

  1. Adamczyk W, Tafil-Klawe M, Chesy G, Klawe JJ, Szeliga-Wczysla M, Zlomanczuk P (2006) Effects of training on the ventilatory response to hypoxia. J Physiol Pharmacol 57 Suppl 4: 7-14

    PubMed  Google Scholar 

  2. Akiyama Y, Nishimura M, Suzuki A, Yamamoto M, Kawakami Y (1991) Peripheral chemosensitivity assessed by the modified transient O2 test in female twins. Chest 100: 102-105

    PubMed  CAS  Google Scholar 

  3. Arkinstall WW, Nirmel K, Klissouras V, Milic-Emili J (1974) Genetic differences in the ventilatory response to inhaled CO2. J Appl Physiol 36: 6-11

    PubMed  CAS  Google Scholar 

  4. Bandopadhyay P, Selvamurthy W (2000) Suggested predictive indices for high altitude pulmonary oedema. J Assoc Physicians India 48: 290-294

    PubMed  CAS  Google Scholar 

  5. Beall CM (2000) Tibetan and Andean patterns of adaptation to high-altitude hypoxia. Hum Biol 72: 201-208

    PubMed  CAS  Google Scholar 

  6. Beral V, Read DJ (1971) Insensitivity of respiratory centre to carbon dioxide in the Enga people of New Guinea. Lancet 2: 1290-1294

    Article  PubMed  CAS  Google Scholar 

  7. Bjurstrom RL, Schoene RB (1987) Control of ventilation in elite synchronized swimmers. J Appl Physiol 63: 1019-1024

    PubMed  CAS  Google Scholar 

  8. Black CP, Tenney SM (1980) Oxygen transport during progressive hypoxia in high-altitude and sea-level waterfowl. Respir Physiol 39: 217-239

    Article  PubMed  CAS  Google Scholar 

  9. Bradley CA, Fleetham JA, Anthonisen NR (1979) Ventilatory control in patients with hypoxemia due to obstructive lung disease. Am Rev Respir Dis 120: 21-30

    PubMed  CAS  Google Scholar 

  10. Burtscher M, Flatz M, Faulhaber M (2004) Prediction of susceptibility to acute mountain sickness by SaO2 values during short-term exposure to hypoxia. High Alt Med Biol 5: 335-340

    PubMed  Google Scholar 

  11. Byrne-Quinn E, Sodal IE, Weil JV (1972) Hypoxic and hypercapnic ventilatory drives in children native to high altitude. J Appl Physiol 32: 44-46

    PubMed  CAS  Google Scholar 

  12. Byrne-Quinn E, Weil JV, Sodal IE, Filley GF, Grover RF (1971) Ventilatory control in the athlete. J Appl Physiol 30: 91-98

    PubMed  CAS  Google Scholar 

  13. Chiodi H (1957) Respiratory adaptations to chronic high altitude hypoxia. J Appl Physiol 10: 81-87

    PubMed  CAS  Google Scholar 

  14. Collins DD, Scoggin CH, Zwillich CW, Weil JV (1978) Hereditary aspects of decreased hypoxic response. J Clin Invest 62: 105-110

    PubMed  CAS  Google Scholar 

  15. Curran LS, Zhuang J, Sun SF, Moore LG (1997) Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m. J Appl Physiol 83: 2098-2104

    PubMed  CAS  Google Scholar 

  16. Fleetham JA, Arnup ME, Anthonisen NR (1984) Familial aspects of ventilatory control in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 129: 3-7

    PubMed  CAS  Google Scholar 

  17. Forster HV, Dwinell MR, Hodges MR, Brozoski D, Hogan GE (2003) Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing? Respir Physiol Neurobiol 135: 247-261

    Article  PubMed  CAS  Google Scholar 

  18. Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills W (1988) Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol 64: 1268-1272

    PubMed  CAS  Google Scholar 

  19. Hirshman CA, McCullough RE, Weil JV (1975) Normal values for hypoxic and hypercapnic ventilatory drives in man. J Appl Physiol 38: 1095-1098

    PubMed  CAS  Google Scholar 

  20. Hohenhaus E, Paul A, McCullough RE, Kucherer H, Bartsch P (1995) Ventilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema. Eur Respir J 8: 1825-1833

    Article  PubMed  CAS  Google Scholar 

  21. Hudgel DW, Weil JV (1974) Asthma associated with decreased hypoxic ventilatory drive. A family. Ann Intern Med 80: 623-625

    CAS  Google Scholar 

  22. Jokic R, Zintel T, Sridhar G, Gallagher CG, Fitzpatrick MF (2000) Ventilatory responses to hypercapnia and hypoxia in relatives of patients with the obesity hypoventilation syndrome. Thorax 55: 940-945

    Article  PubMed  CAS  Google Scholar 

  23. Katayama K, Sato Y, Morotome Y, Shima N, Ishida K, Mori S, Miyamura M (2000) Cardiovascular response to hypoxia after endurance training at altitude and sea level and after detraining. J Appl Physiol 88: 1221-1227

    Article  PubMed  CAS  Google Scholar 

  24. Kawakami Y, Irie T, Kishi F, Asanuma Y, Shida A, Yoshikawa T, Kamishima K, Hasegawa H, Murao M (1981) Familial aggregation of abnormal ventilatory control and pulmonary function in chronic obstructive pulmonary disease. Eur J Respir Dis 62: 56-64

    PubMed  CAS  Google Scholar 

  25. Kawakami Y, Yamamoto H, Yoshikawa T, Shida A (1984) Chemical and behavioral control of breathing in adult twins. Am Rev Respir Dis 129: 703-707

    PubMed  CAS  Google Scholar 

  26. Kawakami Y, Yoshikawa T, Shida A, Asanuma Y, Murao M (1982) Control of breathing in young twins. J Appl Physiol 52: 537-542

    PubMed  CAS  Google Scholar 

  27. Kobayashi S, Nishimura M, Yamamoto M, Akiyama Y, Kishi F, Kawakami Y (1993) Dyspnea sensation and chemical control of breathing in adult twins. Am Rev Respir Dis 147: 1192-1198

    PubMed  CAS  Google Scholar 

  28. Lane DJ, Howell JB (1970) Relationship between sensitivity to carbon dioxide and clinical features in patients with chronic airways obstruction. Thorax 25: 150-159

    Article  PubMed  CAS  Google Scholar 

  29. Leitch AG (1976) Chemical control of breathing in identical twin athletes. Ann Hum Biol 3: 447-454

    Article  PubMed  CAS  Google Scholar 

  30. Levine BD, Friedman DB, Engfred K, Hanel B, Kjaer M, Clifford PS, Secher NH (1992) The effect of normoxic or hypobaric hypoxic endurance training on the hypoxic ventilatory response. Med Sci Sports Exerc 24: 769-775

    PubMed  CAS  Google Scholar 

  31. Mahler DA, Moritz ED, Loke J (1982) Ventilatory responses at rest and during exercise in marathon runners. J Appl Physiol 52: 388-392

    PubMed  CAS  Google Scholar 

  32. Markov G, Orler R, Boutellier U (1996) Respiratory training, hypoxic ventilatory response and acute mountain sickness. Respir Physiol 105: 179-186

    Article  PubMed  CAS  Google Scholar 

  33. Masuyama S, Kimura H, Sugita T, Kuriyama T, Tatsumi K, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Watanabe S, Honda Y (1986) Control of ventilation in extreme-altitude climbers. J Appl Physiol 61: 500-506

    PubMed  CAS  Google Scholar 

  34. Matsuzawa Y, Fujimoto K, Kobayashi T, Namushi NR, Harada K, Kohno H, Fukushima M, Kusama S (1989) Blunted hypoxic ventilatory drive in subjects susceptible to high-altitude pulmonary edema. J Appl Physiol 66: 1152-1157

    PubMed  CAS  Google Scholar 

  35. Matthews AW, Howell JB (1976) Assessment of responsiveness to carbon dioxide in patients with chronic airways obstruction by rate of isometric inspiratory pressure development. Clin Sci Mol Med 50: 199-205

    PubMed  CAS  Google Scholar 

  36. Moore GC, Zwillich CW, Battaglia JD, Cotton EK, Weil JV (1976) Respiratory failure associated with familial depression of ventilatory response to hypoxia and hypercapnia. N Engl J Med 295: 861-865

    Article  PubMed  CAS  Google Scholar 

  37. Moore LG (2000) Comparative human ventilatory adaptation to high altitude. Respir Physiol 121: 257-276

    Article  PubMed  CAS  Google Scholar 

  38. Moore LG, Harrison GL, McCullough RE, McCullough RG, Micco AJ, Tucker A, Weil JV, Reeves JT (1986) Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness. J Appl Physiol 60: 1407-1412

    PubMed  CAS  Google Scholar 

  39. Mountain R, Zwillich C, Weil J (1978) Hypoventilation in obstructive lung disease. The role of familial factors. N Engl J Med 298: 521-525

    Article  PubMed  CAS  Google Scholar 

  40. Ohyabu Y, Usami A, Ohyabu I, Ishida Y, Miyagawa C, Arai T, Honda Y (1990) Ventilatory and heart rate chemosensitivity in track-and-field athletes. Eur J Appl Physiol Occup Physiol 59: 460-464

    Article  PubMed  CAS  Google Scholar 

  41. Robin ED, O’Neill RP (1963) The fighter versus the non-fighter. Control of ventilation in chronic obstructive pulmonary disease. Arch Environ Hlth 7: 125-129

    CAS  Google Scholar 

  42. Scadding JG (1963) Meaning of diagnostic terms in bronchopulmonary disease. Brit Med J 2: 1435-1430

    Google Scholar 

  43. Schaeffer KE (1958) Respiratory pattern and respiratory response to CO2. J Appl. Physiol. 13: 1-14

    Google Scholar 

  44. Schoene RB (1982) Control of ventilation in climbers to extreme altitude. J Appl Physiol 53: 886-890.

    Article  PubMed  CAS  Google Scholar 

  45. Schoene RB, Robertson HT, Pierson DJ, Peterson AP (1981) Respiratory drives and exercise in menstrual cycles of athletic and nonathletic women. J Appl Physiol 50: 1300-1305

    PubMed  CAS  Google Scholar 

  46. Scoggin CH, Doekel RD, Kryger MH, Zwillich CW, Weil JV (1978) Familial aspects of decreased hypoxic drive in endurance athletes. J Appl Physiol 44: 464-468

    PubMed  CAS  Google Scholar 

  47. Severinghaus JW, Bainton CR, Carcelen A (1966) Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir Physiol 1: 308-334.

    Article  PubMed  CAS  Google Scholar 

  48. Sorensen SC, Severinghaus JW (1968) Respiratory insensitivity to acute hypoxia persisting after correction of tetralogy of Fallot. J Appl Physiol 25: 221-223

    PubMed  CAS  Google Scholar 

  49. Tankersley CG (2001) Selected contribution: variation in acute hypoxic ventilatory response is linked to mouse chromosome 9. J Appl Physiol 90: 1615-1622

    PubMed  CAS  Google Scholar 

  50. Terblanche JS, Tolley KA, Fahlman A, Myburgh KH, Jackson S (2005) The acute hypoxic ventilatory response: testing the adaptive significance in human populations. Comp Biochem Physiol A Mol Integr Physiol 140: 349-362

    Article  PubMed  CAS  Google Scholar 

  51. Thomas DA, Swaminathan S, Beardsmore CS, McArdle EK, MacFadyen UM, Goodenough PC, Carpenter R, Simpson H (1993) Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. Am Rev Respir Dis 148: 1605-1609

    PubMed  CAS  Google Scholar 

  52. Vizek M, Pickett CK, Weil JV (1987) Interindividual variation in hypoxic ventilatory response: potential role of carotid body. J Appl Physiol 63: 1884-1889

    PubMed  CAS  Google Scholar 

  53. Weil JV, Byrne-Quinn E, Sodal IE, Filley GF, Grover RF (1971) Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J Clin Invest 50: 186-195

    Article  PubMed  CAS  Google Scholar 

  54. Weil JV, Byrne-Quinn E, Sodal IE, Friesen WO, Underhill B, Filley GF, Grover RF (1970) Hypoxic ventilatory drive in normal man. J Clin Invest 49: 1061-1072

    PubMed  CAS  Google Scholar 

  55. Weil JV, Stevens T, Pickett CK, Tatsumi K, Dickinson MG, Jacoby CR, Rodman DM (1998) Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats. Am J Physiol 274: L767-774

    PubMed  CAS  Google Scholar 

  56. Weil JV (2003) Variation in human ventilatory control-genetic influence on the hypoxic ventilatory response. Respir Physiol Neurobiol 135: 239-346

    Article  PubMed  CAS  Google Scholar 

  57. Wu T, Li S, Ward MP (2005) Tibetans at extreme altitude. Wilderness Environ Med 16: 47-54

    Article  PubMed  Google Scholar 

  58. Zhuang J, Droma T, Sun S, Janes C, McCullough RE, McCullough RG, Cymerman A, Huang SY, Reeves JT, Moore LG (1993) Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3,658 m. J Appl Physiol 74: 303-311

    PubMed  CAS  Google Scholar 

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  1. University of Colorado Health Sciences Center, University of Colorado Health Sciences Center, 4200 E. Ninth Ave, Denver, Colorado, 80220, U.S.A

    John V. Weil

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Weil, J.V. (2008). Hereditary aspects of respiratory control in health and disease in humans. In: Genetic Basis for Respiratory Control Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70765-5_2

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