When the editors of this book invited me to write an introduction, my first reaction was that many others were more qualified to introduce a topic that has enjoyed so many recent developments of major importance, including singularly successful clinical applications, unusual for genetic diseases. The task, I felt, would be much better fulfilled by one of the pioneers of the field, several of whom are still in the forefront of research today. Then, it occurred to me that, as a witness to the circuitous pathway whereby lysosomes and storage diseases were first brought together, I had a story to tell that could perhaps be of interest, and hold some instructive aspects, especially to the younger generations. In order to stay within the boundaries of my competence, my story is restricted to events with which I have been personally associated. To put those events
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baudhuin, P., Hers, H.G., and Loeb, H. (1964). An electron-microscopic and biochemical study of Type II glycogenosis. Lab. Invest. 13: 1140-1152 (1964).
de Barsy, T., Jacquemin, P., Van Hoof, F., and Hers, H.G. (1973). Enzyme replacement in Pompe disease: an attempt with purified human α-glucosidase. Enzyme Therapy and Genetic Diseases, Birth Defects, Original Article Series, 9: 184-190.
de Duve, C. (1963). The lysosome concept. In: de Reuck, V.S. and Cameron, M.P. (Eds.), Ciba Foundation Symposium on Lysosomes. London: J. & A. Churchill, pp. 1-35.
de Duve, C. (1964a). From cytases to lysosomes. Fed. Proc. 23: 1045-1049.
de Duve, C. (1964b). Born-again glucagon. FASEB J. 5: 979-981.
de Duve, C. (1969). The lysosome in retrospect. In: Dingle, J.T. and Fell, H.B. (Eds.), Lysosomes in Biology and Pathology, Vol. 1. Amsterdam: North-Holland, pp. 3-40.
de Duve, C. (2004). My love affair with insulin. J. Biol. Chem. 27:9, 21679-21688.
de Duve, C. and Wattiaux, R. (1966). Functions of lysosomes. Annu. Rev. Physiol. 28: 435-492.
de Duve, C., Pressman, B.C., Gianetto, R., Wattiaux, R., and Appelmans, F. (1955). Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem. J. 60: 604-617.
Hers, H.G. (1963). α-Glucosidase deficiency in generalized glycogen storage disease (Pompe’s disease). Biochem. J. 86: 11-16.
Hers, H.G. (1965). Inborn lysosomal diseases. Gastroenterology, 48: 625-633.
Hers, H.G. (1983). From fructose to fructose 2,6-bisphosphate, with a detour through lysosomes and glycogen. In: Semenza, G. (Ed.), Selected Topics in the History of Biochemistry, Amsterdam: Elsevier Science, pp. 71-101.
Hers, H.G. and Van Hoof, F. (1973). Lysosomes and Storage Diseases. New York: Academic Press.
Lejeune, N., Thinès-Sempoux, D., and Hers, H.G. (1963). Tissue fractionation studies. 16. Intracellular distribution and properties of α-glucosidases in rat liver. Biochem. J. 86: 16-21.
Tulkens, P., Trouet, A., and Van Hoof, F. (1970). Immunological inhibition of lysosome function. Nature, 228: 1282-1285.
Van Hoof, F. and Hers, H.G. (1968). The abnormalities of lysosomal enzymes in mucopolysacccharidoses. Eur. J. Biochem. 7: 34-44.
Wattiaux, R., Wibo, M., and Baudhuin, P. (1963). Influence of the injection of Triton WR-1339 on the properties of rat-liver lysosomes. In: Reuck, A.V.S. and Cameron, M.P. (Eds.), Ciba Foundation Symposium on Lysosomes, London: J. & A. Churchill, pp. 176-200.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
de Duve, C. (2007). From Lysosomes to Storage Diseases and Back: A Personal Reminiscence. In: Lysosomal Storage Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70909-3_1
Download citation
DOI: https://doi.org/10.1007/978-0-387-70909-3_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-70908-6
Online ISBN: 978-0-387-70909-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)