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The Alternative Pathway of Complement: a Pattern Recognition System

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Current Topics in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 598))

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References

  • Asghar, S.S. (1995) Biology of Disease – Membrane Regulators of Complement Activation and their aberrant Expression in Disease. Laboratory Investigation 72 (3), 254-271.

    PubMed  CAS  Google Scholar 

  • Blom, A.M., Rytkonen, A., Vasquez, P., Lindahl, G., Dahlback, B. and Jonsson, A.B. (2001) A novel interaction between type IV pili of Neisseria gonorrhoeae and the human complement regulator C4b-binding protein. J. Immunol. 166 (11), 6764-6770.

    PubMed  CAS  Google Scholar 

  • de Cordoba, R.S., Esparza-Gordillo, J., de Jorge, G.E., Lopez-Trascasa, M. and Sanchez-Corral, P. (2004) The human complement factor H: functional roles, genetic variations and disease associations. Mol. Immunol. 41 (4), 355-67.

    Article  Google Scholar 

  • Dempsey, P.W., Allison, M.E., Akkaraju, S., Goodnow, C.C. and Fearon, D.T. (1996) C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271 (5247), 348-50.

    Article  PubMed  CAS  Google Scholar 

  • Favoreel, H.W., Van de Walle, G.R., Nauwynck, H.J. and Pensaert, M.B. (2003) Virus complement evasion strategies. JOURNAL OF GENERAL VIROLOGY 84, 1-15.

    Article  PubMed  CAS  Google Scholar 

  • Finlay, B.B. and Mc Fadden, G. (2006) Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens. Cell 24 (4), 767-782.

    Article  Google Scholar 

  • Foster, T.J. (2005) Immune evasion by Staphylococci. Nature Reviews Microbiology 3 (12), 948-958.

    Article  PubMed  CAS  Google Scholar 

  • Friese, M.A., Hellwage, J., Jokiranta, T.S., Meri, S., Peter, H.H., Eibel, H. and Zipfel, P.F. (1999) Different transcriptional regulation and expression of members of the factor H family by inflammatory mediators and in rheumatoid arthritis. Mol. Immunol. 36 (4–5), 281-281.

    Google Scholar 

  • Janeway, C.A. and Medzhitov, R. (2002) Innate immune recognition. Annual Review of Immunology 20, 197-216.

    Article  PubMed  CAS  Google Scholar 

  • Jenkins, H.T., Mark, L., Ball, G., Persson, J., Lindahl, G., Uhrin, D., Blom, A.M. and Barlow, P.N. (2006) Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. J. Biol. Chem. 281 (6), 3690-3697.

    Article  PubMed  CAS  Google Scholar 

  • Jokiranta, T.S., Cheng, Z.Z., Seeberger, H., Jozsi, M., Heinen, S., Noris ,M., Remuzzi, G., Ormsby, R., Gordon, D.L., Meri, S., Hellwage, J. and Zipfel, P.F. (2005) Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site. Am. J. Pathol. 167 (4), 1173-1181.

    PubMed  CAS  Google Scholar 

  • Jozsi, M., Heinen, S. and Zipfel, P.F. (2006) Protective role of surface-attached complement factor H for endothelial cells. Mol. Immunol. 43 (1–2), 143-143.

    Google Scholar 

  • Kim, D.D. and Song, W.C. (2006) Membrane complement regulatory proteins. Clinical. Immunol. 118 (2–3), 127-136.

    Article  CAS  Google Scholar 

  • Kimbrell, D.A. and Beutler, B. (2001) The evolution and genetics of innate immunity. Nature Reviews Genetics 2 (4), 256-267.

    Article  PubMed  CAS  Google Scholar 

  • Kraiczy, P. and Wurzner, R. (2006) Complement escape of human pathogenic bacteria by acquisition of complement regulators. Mol. Immunol. 43 (1-2), 31-44.

    Article  PubMed  CAS  Google Scholar 

  • Kraiczy, P., Hellwage, J., Skerka, C., Becker, H., Kirschfink, M., Simon, M.M., Brade, V., Zipfel, P.F. and Wallich, R. (2004) Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. J. Biol. Chem. 279 (4), 2421-2429.

    Article  PubMed  CAS  Google Scholar 

  • Krych-Goldberg, M. and Atkinson, J.P. (2001) Structure-function relationships of complement receptor type 1. Immunol. Reviews 180, 112-122.

    Article  CAS  Google Scholar 

  • Lambris, J.D., Reid, K.B.M. and Volanakis, J.E. (1999) The evolution, structure, biology and pathophysiology of complement. Immunology Today 20 (5), 207-211.

    Article  PubMed  CAS  Google Scholar 

  • Lee, S.H., Jung, J.U. and Means, R.E. (2003) ‘Complementing’ viral infection: mechanisms for evading innate immunity. Trends in Microbiol. 11 (10), 449-452.

    Article  CAS  Google Scholar 

  • Lindahl, G., Sjobring, U. and Johnsson, E. (2000) Human complement regulators: a major target for pathogenic microorganisms. Current Opinion in Immunol. 12 (1), 44-51.

    Article  CAS  Google Scholar 

  • Liszewski, M.K. and Atkinson, J.P. (1992) Membrane cofactor protein. Current Topics in Microbiology and Immunology 178, 45-60.

    PubMed  CAS  Google Scholar 

  • Lublin, D.M. and Atkinson, J.P. (1989) Decay-accelerating factor: biochemistry, molecular biology, and function. Annual Review of Immunology 7, 35-58.

    Article  PubMed  CAS  Google Scholar 

  • Mark, L., Spiller, O.B., Villoutreix, B.O. and Blom, A.M.(2007) Kaposi’s sarcoma-associated herpes virus complement control protein: KCP - complement inhibition and more. Molecular Immunology 44 (1–3), 11-22.

    Article  PubMed  CAS  Google Scholar 

  • Mc Kenzie, R., Kotwal, G.J., Moss, B., Hammer, C.H. and Frank, M.M. (1992) Regulation of Complement Activity by Vaccinia Virus Complement-Control Protein. J. Infectious Diseases 166 (6), 1245-1250.

    CAS  Google Scholar 

  • Medzhitov, R. and Janeway, C.A. (1997) Innate immunity: Impact on the adaptive immune response. Current Opinion in Immunol. 9 (1), 4-9.

    Article  CAS  Google Scholar 

  • Meri, T., Hartmann, A., Lenk, D., Eck, R., Wurzner, R., Hellwage, J., Meri, S. and Zipfel, P.F. (2002) The yeast Candida albicans binds complement regulators factor H and FHL-1. Infection and Immunity 70 (9), 5185-5192.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, B.P. and Harris, C.L. (1999) Regulation in the complement system. In: Morgan, B.P., Harris, C.L., Complement Regulatory Proteins. Academic Press 32-40.

    Google Scholar 

  • Mullick, J., Bernet, J., Panse, Y., Hallihosur, S., Singh, A.K. and Sahu, A. (2005) Identification of complement regulatory domains in vaccinia virus complement control protein. J. Virol. 79 (19), 12382-12393.

    Article  PubMed  CAS  Google Scholar 

  • Mullick, J., Kadam, A. and Sahu, A. (2003) Herpes and pox viral complement control proteins: ‘the mask of self”. Trends in Immunology 24 (9), 500-507.

    Article  PubMed  CAS  Google Scholar 

  • Nordahl, E.A., Rydengard, V., Nyberg, P., Nitsche, DP., Morgelin, M., Malmsten, M., Bjorck, L. and Schmidtchen A. (2004) Activation of the complement system generates antibacterial peptides. Proceedings of the Nat. Acad. Of Sciences of the USA 101 (48), 16879-16884.

    Article  CAS  Google Scholar 

  • Pangburn, M.K. (1998) Alternative Pathway: Activation and Regulation. In: Rother, K., Till, G.O., Hänsch, G.M (Eds.), The complement system. Springer, Berlin 93-115.

    Google Scholar 

  • Sacks, D. and Sher, A. (2002) Evasion of innate immunity by parasitic protozoa. Nature Immunol. 3 (11), 1041-1047.

    Article  CAS  Google Scholar 

  • Sahu, A. and Lambris, J.D. (2001) Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews 180, 35-48.

    Article  PubMed  CAS  Google Scholar 

  • Schlaf, G., Demberg, T., Beisel, N., Schieferdecker, H.L. and Gotze, O. (2001) Expression and regulation of complement factors H and I in rat and human cells: some critical notes. Mol. Immunol. 38 (2–3), 231-239.

    Article  PubMed  CAS  Google Scholar 

  • Seya, T., Hirano, A., Matsumoto, M., Nomura, M. and Ueda, S. (1999) Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions. The International Journal of Biochemistry & Cell Biology 31(11), 1255-60.

    Article  CAS  Google Scholar 

  • Schulenburg, H., Kurz, C.L. and Ewbank, J.J. (2004) Evolution of the innate immune system: the worm perspective. \textit{Immunological Reviews 198 (1), 36-58.

    Article  CAS  Google Scholar 

  • Thurman, J.M., Holers, V.M. (2006) The central role of the alternative complement pathway in human disease. J. Immunol. 176 (3),1305-1310.

    PubMed  CAS  Google Scholar 

  • Uematsu, S. and Akira, S. (2006) Toll-like receptors and innate immunity. J. Mol. Med. 84 (9), 712-725.

    Article  PubMed  CAS  Google Scholar 

  • Volanakis, J.E. (2002) The role of complement in innate and adaptive immunity. Current Topics in Microbiol. And Immunol. 266, 41-56.

    CAS  Google Scholar 

  • Walport, M.J. (2001) Advances in immunology: Complement (First of two parts). New England J. Med. 344 (14), 1058-1066.

    Article  CAS  Google Scholar 

  • Zipfel, P.F., Heinen, S., Jozsi, M. and Skerka, C. (2006) Complement and diseases: Defective alternative pathway control results in kidney and eye diseases. Mol. Immunol. 43, 97-106.

    Article  PubMed  CAS  Google Scholar 

  • Zipfel, P.F. (2001) Complement factor H: Physiology and pathophysiology. Seminars in Thrombosis and Hemostasis 27 (3), 191-199.

    Article  PubMed  CAS  Google Scholar 

  • Zipfel P.F. and Skerka, C. (1994) Complement Factor-H and Related Proteins – An Expanding Family of Complement-Regulatory Proteins. Immunology Today 15 (3), 121-126.

    Article  PubMed  CAS  Google Scholar 

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Zipfel, P.F., Mihlan, M., Skerka, C. (2007). The Alternative Pathway of Complement: a Pattern Recognition System. In: Lambris, J.D. (eds) Current Topics in Innate Immunity. Advances in Experimental Medicine and Biology, vol 598. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71767-8_7

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