Abstract
The concept of “vasculogenic mimicry” (VM) was introduced to describe the unique ability of highly aggressive tumor cells to form capillary-like structure (CLS) and matrix-rich patterned network in three-dimensional cultures that mimic embryonic vasculogenic network. Here, we provide the experimental evidence that CLS structure formation requires apoptotic cell death through activation of caspase-dependent mechanism. Our results indicate that the formation of CLS is also related to the reactive oxygen species (ROS) levels.
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Vartanian, A., Baryshnikov, A.Y. (2007). Crosstalk Between Apoptosis and Antioxidants in Melanoma Vasculogenic Mimicry. In: Shurin, M.R., Smolkin, Y.S. (eds) Immune-Mediated Diseases. Advances in Experimental Medicine and Biology, vol 601. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72005-0_15
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DOI: https://doi.org/10.1007/978-0-387-72005-0_15
Publisher Name: Springer, New York, NY
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