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New Tools for Assessing Breast Cancer Recurrence

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Advances in Breast Cancer Management, Second Edition

Part of the book series: Cancer Treatment and Research ((CTAR,volume 141))

Breast cancer is the most common cancer in women in the Western world, and is essentially incurable when distant metastases are detected. Despite an increasing incidence, breast cancer mortality has fallen, largely due to the advent of widespread screening programs, but also partly due to the increasing use of adjuvant systemic treatment and advances in loco-regional control.

This chapter will review the advances in gene expression profiling, made possible with microarray technology, as new tools for assessing breast cancer recurrence. It will discuss the molecular classification of breast cancer subtypes, as well as the various molecular signatures with their prognostic and predictive implications. Two prospective randomized trials, MINDACT and TAILORx, designed to validate this new technology, will be briefly discussed.

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Author information

Authors and Affiliations

  1. Department of Medical Oncology, Universite Libre de Bruxelles, 121 Boulevard de Waterloo, 1000, Brussels, Belgium

    Phuong Dinh M.D., Fatima Cardoso M.D., Christos Sotiriou M.D., Ph.D. & Martine J. Piccart-Gebhart M.D., Ph.D.

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  1. Phuong Dinh M.D.
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  2. Fatima Cardoso M.D.
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  3. Christos Sotiriou M.D., Ph.D.
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  4. Martine J. Piccart-Gebhart M.D., Ph.D.
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Editors and Affiliations

  1. Northwestern University School of Medicine, 675 North St, 60611, Chicago, IL, USA

    William J. Gradishar M.D.

  2. Emory University School of Medicine, 201 Dowman Drive, 30322, Atlanta, GA, USA

    William C. Wood M.D.

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Dinh, P., Cardoso, F., Sotiriou, C., Piccart-Gebhart, M.J. (2008). New Tools for Assessing Breast Cancer Recurrence. In: Gradishar, W.J., Wood, W.C. (eds) Advances in Breast Cancer Management, Second Edition. Cancer Treatment and Research, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73161-2_7

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  • DOI: https://doi.org/10.1007/978-0-387-73161-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-73160-5

  • Online ISBN: 978-0-387-73161-2

  • eBook Packages: MedicineMedicine (R0)

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