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Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery

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Multifunctional Pharmaceutical Nanocarriers

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 4))

Apart from its previous history in pharmaceutics, nanotechnology has recently become a major paradigm for the delivery of anticancer drugs, imaging agents, and genetic material. Pharmaceutical nanosystems have shown beneficial therapeutic efficacy with reduced side effects in treating diseases when compared to traditional dosage forms. For example, delivery of high doses of therapeutic and/or diagnostic agents to target cancer sites has been achieved using nano-sized carrier systems. This effect is primarily attributed to passive accumulation in solid tumors and inflamed regions by the EPR effect and the size (20–200 nm) of the carriers, followed by passive diffusional release of the drug in the extracellular space and/or active internalization into the cells via various entry mechanisms.

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Authors and Affiliations

  1. Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 84108, Salt Lake City, UT, USA

    Han Chang Kang, Eun Seong Lee & You Han Bae

  2. Division of Biotechnology, The Catholic University of Korea, 420-743, Gyeonggi-do, Korea

    Kun Na

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  1. Han Chang Kang
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  1. Northeastern University, 02115, Boston, MA, USA

    Vladimir Torchilin

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Kang, H.C., Lee, E.S., Na, K., Bae, Y.H. (2008). Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery. In: Torchilin, V. (eds) Multifunctional Pharmaceutical Nanocarriers. Fundamental Biomedical Technologies, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76554-9_6

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