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OX40 (CD134) and OX40L

  • Chapter
Therapeutic Targets of the TNF Superfamily

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 647))

Abstract

The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. While OX40 is expressed predominantly on T-lymphocytes early after antigen activation, OX40L is expressed on activated antigen presenting cells and endothelial cells within acute inflammatory environments. We discuss here how ligation of OX40 by OX40L leads to enhanced T-cell survival, along with local inflammatory responses that appear critical for both effective T-cell mediated responses and chronic immune pathologies. We describe how interventions that block or mimic the OX40-OX40L interaction can be applied to treat autoimmune diseases or enhance anti-tumor immune responses. The clinically relevant properties of these agents emphasize the importance of this particular TNFSF-TNFSF in health and disease.

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Authors and Affiliations

  1. Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA

    Michael J. Gough & Andrew D. Weinberg

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  1. Michael J. Gough
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  2. Andrew D. Weinberg
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  1. Department of Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA

    Iqbal S. Grewal PhD

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© 2009 Landes Bioscience and Springer Science+Business Media

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Gough, M.J., Weinberg, A.D. (2009). OX40 (CD134) and OX40L. In: Grewal, I.S. (eds) Therapeutic Targets of the TNF Superfamily. Advances in Experimental Medicine and Biology, vol 647. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89520-8_6

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