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The Structure and Expression of the Nerve Growth Factor Receptors

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Brain Repair

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

Neurotrophic factors, of the type characterized by nerve growth factor (NGF, Levi-Montalcini, 1987) are synthesized in limiting amounts in, and secreted from, the target cells of the innervated neurons and then carried by retrograde flow from the nerve terminal to the neuronal cell body (Thoenen and Barde, 1980). Synthesis of NGF in the target cells and retrograde flow begin at the time in development when the growing axons reach the target and, indeed, only those neurons which establish this flow survive the period of neuronal cell death and become mature, fully differentiated neurons (Davies et al. 1987). The onset of NGF synthesis in the target is actually independent of the arrival of the growing nerve fiber suggesting that NGF synthesis in target cells is regulated by an, as yet unknown, exogenous factor (Rohrer et al., 1988). Retrograde flow of NGF, once established, persists for the life time of the particular neuron and is one of the factors which controls the survival and/or the maintenance of the differentiated state of the cell.

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Authors
  1. Catherine Bitler
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  2. Susan O. Meakin
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  3. Monte J. Radeke
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  4. David H. Shelton
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  5. Andrew Welcher
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  6. Eric M. Shooter
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Editor information

Editors and Affiliations

  1. Department of Medical Cell Research, University of Lund, Sweden

    Anders Björklund

  2. Center for Research in Neuroscience, Montreal General Hospital, Canada

    Albert J. Aguayo

  3. Wenner-Gren Center Foundation, Stockholm, Sweden

    David Ottoson

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© 1990 The contributors

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Bitler, C., Meakin, S.O., Radeke, M.J., Shelton, D.H., Welcher, A., Shooter, E.M. (1990). The Structure and Expression of the Nerve Growth Factor Receptors. In: Björklund, A., Aguayo, A.J., Ottoson, D. (eds) Brain Repair. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-11358-3_4

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  • DOI: https://doi.org/10.1007/978-1-349-11358-3_4

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-11360-6

  • Online ISBN: 978-1-349-11358-3

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