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Computational Fluid Dynamics Applied to Laboratory Scale Cell Culture Reactors for the Prediction of Hydrodynamic Stress

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Cell Technology for Cell Products

Abstract

Using Computational Fluid Dynamics, a method for the design of animal cell culture reactors is proposed. This approach is based on the concept of Fluid Stress Distribution and on the calculation of animal cell paths.

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References

  • Haut, B., Ben Amor, H., Coulon, A., Jacquet, A., Halloin, V. 2003. Hydrodynamics and mass transfer in a Couette-Taylor bioreactor for the culture of animal cells, Chem. Eng. Sci. 58 777–784.

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  • Morsi, S.A. and Alexander, A.J. 1972, An investigation of particle trajectories in two-phase flow systems, J. Fluid Mech. 55 193–208.

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© 2007 Springer

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Olmos, E., Fischbach, N., Marc, A. (2007). Computational Fluid Dynamics Applied to Laboratory Scale Cell Culture Reactors for the Prediction of Hydrodynamic Stress. In: Smith, R. (eds) Cell Technology for Cell Products., vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5476-1_103

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