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Orthotopic Metastatic Mouse Models of Prostate Cancer

  • Chapter
Metastasis of Prostate Cancer

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 10))

Abstract

Orthotopic metastatic models of prostate cancer are reviewed here. Emphasis is placed on surgical orthotopic implantation models in nude mice. The advantages of surgical orthotopic implantation of tissue fragments are discussed with regard to resulting metastasis which reflect the clinical pattern of prostate cancer. The use of green Cancer statistics, luorescent protein and red fluorescent protein to image primary tumor growth and metastasis, including whole-body imaging of prostate cancer, is discussed. The application of the models for gene expression studies, drug discovery, and gene therapy is also reviewed.

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Authors and Affiliations

  1. Department of Surgery, UCSD Medical Center, San Diego, CA, USA

    Robert M. Hoffman

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  1. Robert M. Hoffman
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Editors and Affiliations

  1. University of Arizona College of Medicine, and the Arizona Cancer Center, Tucson, AZ, U.S.A

    Richard J. Ablin

  2. University of Cardiff, U.K

    Malcolm D. Mason

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© 2008 Springer Science+Business Media B.V.

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Hoffman, R.M. (2008). Orthotopic Metastatic Mouse Models of Prostate Cancer. In: Ablin, R.J., Mason, M.D. (eds) Metastasis of Prostate Cancer. Cancer Metastasis – Biology and Treatment, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5847-9_8

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