Skip to main content

Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral infection described from parts of Africa, Asia, Eastern Europe, and the Middle East [15, 20, 50, 52]. The CCHF virus (CCHFV) belongs to the genus Nairovirus in the family Bunyaviridae and causes a severe disease in humans, with a reported mortality rate of 3–30% [15]. The geographic range of CCHFV is the most extensive of the medically significant tick-borne viruses. Humans become infected through the bites of ticks, by contact with a patient with CCHF during the acute phase of infection, or by contact with blood or tissues from viremic livestock [52].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Al-Tikriti SK, Al-Ani F, Jurji FJ, Tantawi H, Al-Moslih M, Al-Janabi N, Mahmud MI, Al-Bana A, Habib H, Al-Munthri H, Al-Janabi S, K AL-J, Yonan M, Hassan F, Simpson DI (1981) Congo-Crimean haemorrhagic fever in Iraq. Bull World Health Organ 59:85–90.

    PubMed  CAS  Google Scholar 

  2. Antoniadis A, Casals J (1982) Serological evidence of human infection with Congo-Crimean hemorrhagic fever virus in Greece. Am J Trop Med Hyg 31:1066–1067.

    PubMed  CAS  Google Scholar 

  3. Athar MN, Baqai HZ, Ahmad M, Khalid MA, Bashir N, Ahmad AM, Balouch AH, Bashir K (2003) Short report: Crimean-Congo hemorrhagic fever outbreak in Rawalpindi, Pakistan, February 2002. Am J Trop Med Hyg 69:284–287.

    PubMed  Google Scholar 

  4. Baskerville A, Satti A, Murphy FA, Simpson DI (1981) Congo-Crimean haemorrhagic fever in Dubai: histopathological studies. J Clin Pathol 34:871–874.

    Article  PubMed  CAS  Google Scholar 

  5. Burney MI, Ghafoor A, Saleen M, Webb PA, Casals J (1980) Nosocomial outbreak of viral hemorrhagic fever caused by Crimean hemorrhagic fever-Congo virus in Pakistan, January 1976. Am J Trop Med Hyg 29:941–947.

    PubMed  CAS  Google Scholar 

  6. Burt FJ, Leman PA, Abbott JC, Swanepoel R (1994) Serodiagnosis of Crimean-Congo haemorrhagic fever. Epidemiol Infect 113:551–562.

    Article  PubMed  CAS  Google Scholar 

  7. CDC (2005) Bioterrorism http://wwwbtcdcgov/Agent/Agentlistasp.

  8. Chapman LE, Wilson ML, Hall DB, LeGuenno B, Dykstra EA, Ba K, Fisher-Hoch SP (1991) Risk factors for Crimean-Congo hemorrhagic fever in rural northern Senegal. J Infect Dis 164:686–692.

    PubMed  CAS  Google Scholar 

  9. Darwish MA, Imam IZ, Omar FM, Hoogstraal H (1978) Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. Acta Virol 22:77.

    PubMed  CAS  Google Scholar 

  10. Drosten C, Minnak D, Emmerich P, Schmitz H, Reinicke T (2002) Crimean-Congo hemorrhagic fever in Kosovo. J Clin Microbiol 40:1122–1123.

    Article  PubMed  Google Scholar 

  11. Drosten C, Kummerer BM, Schmitz H, Gunther S (2003) Molecular diagnostics of viral hemorrhagic fevers. Antiviral Res 57:61–87.

    Article  PubMed  CAS  Google Scholar 

  12. Dunster L, Dunster M, Ofula V, Beti D, Kazooba-Voskamp F, Burt F, Swanepoel R, DeCock KM (2002) First documentation of human Crimean-Congo hemorrhagic fever, Kenya. Emerg Infect Dis 8:1005–1006.

    PubMed  Google Scholar 

  13. el-Azazy OM, Scrimgeour EM (1997) Crimean-Congo haemorrhagic fever virus infection in the western province of Saudi Arabia. Trans R Soc Trop Med Hyg 91:275–278.

    Article  PubMed  CAS  Google Scholar 

  14. Ergonul O, Akgunduz S, Kocaman I, Vatansever Z, Korten V (2005) Changes in temperature and the Crimean-Congo hemorrhagic fever outbreak in Turkey. In: 15th European Congress of Clinical Microbiology and Infectious Diseases, Copenhagen. Clin Microbiol Infect, p 360.

    Google Scholar 

  15. Ergonul O (2006) Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6:203–214.

    Article  PubMed  Google Scholar 

  16. Estrada-Pena A (2001) Forecasting habitat suitability for ticks and prevention of tick-borne diseases. Vet Parasitol 98:111–132.

    Article  PubMed  CAS  Google Scholar 

  17. Filipe AR, Calisher CH, Lazuick J (1985) Antibodies to Congo-Crimean haemorrhagic fever, Dhori, Thogoto and Bhanja viruses in southern Portugal. Acta Virol 29:324–328.

    PubMed  CAS  Google Scholar 

  18. Gear JH, Thomson PD, Hopp M, Andronikou S, Cohn RJ, Ledger J, Berkowitz FE (1982) Congo-Crimean haemorrhagic fever in South Africa. Report of a fatal case in the Transvaal. S Afr Med J 62:576–580.

    PubMed  CAS  Google Scholar 

  19. Geisbert TW, Jahrling PB (2004) Exotic emerging viral diseases: progress and challenges. Nat Med 10:S110–121.

    Article  PubMed  CAS  Google Scholar 

  20. Hoogstraal H (1979) The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 15:307–417.

    PubMed  CAS  Google Scholar 

  21. Horvath LB (1976) Precipitating antibodies to Crimean haemorrhagic fever virus in human sera collected in Hungary. Acta Microbiol Acad Sci Hung 23:331–335.

    PubMed  CAS  Google Scholar 

  22. Khan AS, Maupin GO, Rollin PE (1997) An outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates, 1994–1995. Am J Trop Med Hyg 57:519–525.

    PubMed  CAS  Google Scholar 

  23. Last JM (1995) A Dictionary of Epidemiology. Oxford University Press, New York.

    Google Scholar 

  24. Mardani M, Jahromi MK, Naieni KH, Zeinali M (2003) The efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Iran. Clin Infect Dis 36:1613–1618.

    Article  PubMed  CAS  Google Scholar 

  25. Nabeth P, Cheikh DO, Lo B, Faye O, Vall IO, Niang M, Wague B, Diop D, Diallo M, Diallo B, Diop OM, Simon F (2004) Crimean-Congo hemorrhagic fever, Mauritania. Emerg Infect Dis 10:2143–2149.

    PubMed  Google Scholar 

  26. Nabeth P, Thior M, Faye O, Simon F (2004) Human Crimean-Congo hemorrhagic fever, Senegal. Emerg Infect Dis 10:1881–1882.

    PubMed  Google Scholar 

  27. Papa A, Bino S, Llagami A, Brahimaj B, Papadimitriou E, Pavlidou V, Velo E, Cahani G, Hajdini M, Pilaca A, Harxhi A, Antoniadis A (2002) Crimean-Congo hemorrhagic fever in Albania, 2001. Eur J Clin Microbiol Infect Dis 21:603–606.

    Article  PubMed  CAS  Google Scholar 

  28. Papa A, Bozovi B, Pavlidou V, Papadimitriou E, Pelemis M, Antoniadis A (2002) Genetic detection and isolation of Crimean-Congo hemorrhagic fever virus, Kosovo, Yugoslavia. Emerg Infect Dis 8:852–854.

    Article  PubMed  Google Scholar 

  29. Papa A, Ma B, Kouidou S, Tang Q, Hang C, Antoniadis A (2002) Genetic characterization of the M RNA segment of Crimean-Congo hemorrhagic fever virus strains, China. Emerg Infect Dis 8:50–53.

    Article  PubMed  CAS  Google Scholar 

  30. Papa A, Christova I, Papadimitriou E, Antoniadis A (2004) Crimean-Congo hemorrhagic fever in Bulgaria. Emerg Infect Dis 10:1465–1467.

    PubMed  Google Scholar 

  31. Papadopoulos O, Koptopoulos G (1980) Crimean-Congo hemorrhagic fever (CCHF) in Greece: isolation of the virus from Rhipicephalus bursa ticks and a preliminary serological survey. Zentbl Bakteriol Hyg 1:189–193.

    Google Scholar 

  32. Randolph SE (2004) Evidence that climate change has caused ‘emergence’ of tick-borne diseases in Europe? Int J Med Microbiol 293 (Suppl 37):5–15.

    PubMed  Google Scholar 

  33. Rodriguez LL, Maupin GO, Ksiazek TG, Rollin PE, Khan AS, Schwarz TF, Lofts RS, Smith JF, Noor AM, Peters CJ, Nichol ST (1997) Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Am J Trop Med Hyg 57:512–518.

    PubMed  CAS  Google Scholar 

  34. Saluzzo JF, Digoutte JP, Cornet M, Baudon D, Roux J, Robert V (1984) Isolation of Crimean-Congo haemorrhagic fever and Rift Valley fever viruses in Upper Volta. Lancet 1:1179.

    Article  PubMed  CAS  Google Scholar 

  35. Saluzzo JF, Digoutte JP, Camicas JL, Chauvancy G (1985) Crimean-Congo haemorrhagic fever and Rift Valley fever in south-eastern Mauritania. Lancet 1:116.

    Article  PubMed  CAS  Google Scholar 

  36. Schwarz TF, Nsanze H, Longson M, Nitschko H, Gilch S, Shurie H, Ameen A, Zahir AR, Acharya UG, Jager G (1996) Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean-Congo hemorrhagic fever virus in the United Arab Emirates. Am J Trop Med Hyg 55:190–196.

    PubMed  CAS  Google Scholar 

  37. Schwarz TF, Nsanze H, Ameen AM (1997) Clinical features of Crimean-Congo haemorrhagic fever in the United Arab Emirates. Infection 25:364–367.

    Article  PubMed  CAS  Google Scholar 

  38. Shanmugam J, Smirnova SE, Chumakov MP (1976) Presence of antibody to arboviruses of the Crimean Haemorrhagic Fever-Congo (CHF-Congo) group in human beings and domestic animals in India. Indian J Med Res 64:1403–1413.

    PubMed  CAS  Google Scholar 

  39. Sheikh AS, Sheikh AA, Sheikh NS, Rafi US, Asif M, Afridi F, Malik MT (2005) Bi-annual surge of Crimean-Congo haemorrhagic fever (CCHF): a five-year experience. Int J Infect Dis 9:37–42.

    Article  PubMed  Google Scholar 

  40. Shepherd AJ, Swanepoel R, Leman PA (1989) Antibody response in Crimean-Congo hemorrhagic fever. Rev Infect Dis 11 (Suppl 4):S801–806.

    PubMed  Google Scholar 

  41. Simpson DIH, Knight EM, Courtois G, Williams MC, Weinbern MP, Kibukamusoke JW (1967) Congo virus: a hitherto undescribed virus occurring in Africa, human isolations and clinical notes. East Afr Med J 44:86–92.

    PubMed  CAS  Google Scholar 

  42. Smego RA, Jr., Sarwari AR, Siddiqui AR (2004) Crimean-Congo hemorrhagic fever: prevention and control limitations in a resource-poor country. Clin Infect Dis 38:1731–1735.

    Article  PubMed  Google Scholar 

  43. Suleiman MN, Muscat-Baron JM, Harries JR, Satti AG, Platt GS, Bowen ET, Simpson DI (1980) Congo/Crimean haemorrhagic fever in Dubai. An outbreak at the Rashid Hospital. Lancet 2:939–941.

    PubMed  CAS  Google Scholar 

  44. Swanepoel R, Struthers JK, Shepherd AJ, McGillivray GM, Nel MJ, Jupp PG (1983) Crimean-Congo hemorrhagic fever in South Africa. Am J Trop Med Hyg 32:1407–1415.

    PubMed  CAS  Google Scholar 

  45. Swanepoel R, Shepherd AJ, Leman PA, Shepherd SP, McGillivray GM, Erasmus MJ, Searle LA, Gill DE (1987) Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am J Trop Med Hyg 36:120–132.

    PubMed  CAS  Google Scholar 

  46. Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S (1989) The clinical pathology of Crimean-Congo hemorrhagic fever. Rev Infect Dis 11 (Suppl 4): S794–800.

    PubMed  Google Scholar 

  47. Tantawi HH, Al-Moslih MI, Al-Janabi NY, Al-Bana AS, Mahmud MI, Jurji F, Yonan MS, Al-Ani F, Al-Tikriti SK (1980) Crimean-Congo haemorrhagic fever virus in Iraq: isolation, identification and electron microscopy. Acta Virol 24:464–467.

    PubMed  CAS  Google Scholar 

  48. van Regenmortel MHV, Fauquet CM, Bishop DML, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mago MA, McGeoch DJ, Pringle CR, Wicknen RB (2000) 7th report of the International Committee of Taxonomy of Viruses. Virus Taxonomy, pp 599–621.

    Google Scholar 

  49. Watts DM, Ksiasek TG, Linthicum KJ, Hoogstraal H (1988) Crimean-Congo hemorrhagic fever. In: Monath TP (ed.) The Arboviruses: Epidemiology and Ecology. CRC Press, Boca Raton, FL.

    Google Scholar 

  50. Watts DM, Ussery MA, Nash D, Peters CJ (1989) Inhibition of Crimean-Congo hemorrhagic fever viral infectivity yields invitro by ribavirin. Am J Trop Med Hyg 41:581–585.

    PubMed  CAS  Google Scholar 

  51. Weber DJ, Menajovsky B, Wenzel R (2001) Investigations of Outbreaks. In: Thomas JC, Weber DJ (eds) Epidemiologic Methods for the Study of Infectious Diseases. Oxford University Press, New York, pp 291–310.

    Google Scholar 

  52. Whitehouse CA (2004) Crimean-Congo hemorrhagic fever. Antiviral Res 64:145–160.

    PubMed  CAS  Google Scholar 

  53. Williams RJ, Al-Busaidy S, Mehta FR, Maupin GO, Wagoner KD, Al-Awaidy S, Suleiman AJ, Khan AS, Peters CJ, Ksiazek TG (2000) Crimean-Congo haemorrhagic fever: a seroepidemiological and tick survey in the Sultanate of Oman. Trop Med Int Health 5:99–106.

    Article  PubMed  CAS  Google Scholar 

  54. Woodall JP, Williams MC, Simpson DI (1967) Congo virus: a hitherto undescribed virus occurring in Africa. II. Identification studies. East Afr Med J 44:93–98.

    PubMed  CAS  Google Scholar 

  55. Yen YC, Kong LX, Lee L, Zhang YQ, Li F, Cai BJ, Gao SY (1985) Characteristics of Crimean-Congo hemorrhagic fever virus (Xinjiang strain) in China. Am J Trop Med Hyg 34:1179–1182.

    PubMed  CAS  Google Scholar 

  56. Zeller HG, Cornet JP, Camicas JL (1994) Experimental transmission of Crimean-Congo hemorrhagic fever virus by West African wild ground-feeding birds to Hyalomma marginatum rufipes ticks. Am J Trop Med Hyg 50:676–681.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Ergonul, O., Whitehouse, C.A. (2007). Introduction. In: Ergonul, O., Whitehouse, C.A. (eds) Crimean-Congo Hemorrhagic Fever. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6106-6_1

Download citation

Publish with us

Policies and ethics