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Transcriptional Regulation of Hepatic Fatty Acid Metabolism

  • Chapter
Lipids in Health and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 49))

Abstract

The liver is a major site of fatty acid synthesis and degradation. Transcriptional regulation is one of several mechanisms controlling hepatic metabolism of fatty acids. Two transcription factors, namely SREBP1-c and PPARα, appear to be the main players controlling synthesis and degradation of fatty acids respectively. This chapter briefly presents fatty acid metabolism. The first part focuses on SREBP1-c contribution to the control of gene expression relevant to fatty acid synthesis and the main mechanisms of activation for this transcriptional program. The second part reviews the evidence for the involvement of PPARα in the control of fatty acid degradation and the key features of this nuclear receptor. Finally, the third part aims at summarizing recent advances in our current understanding of how these two transcription factors fit in the regulatory networks that sense hormones or nutrients, including cellular fatty acids, and govern the transcription of genes implicated in hepatic fatty acid metabolism.

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Authors and Affiliations

  1. Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique (INRA), 180 Chemin de Tournefeuille, BP 3, F 31931, TOULOUSE, Cedex 9, France

    Thierry Pineau

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  1. Hervé Guillou
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  2. Pascal G.P. Martin
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  3. Thierry Pineau
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  1. Biochemistry Department, King’s College London, 150 Stamford Street, London SE1 9NH, UK

    Peter J. Quinn

  2. State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China

    Xiaoyuan Wang

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Guillou, H., Martin, P.G., Pineau, T. (2008). Transcriptional Regulation of Hepatic Fatty Acid Metabolism. In: Quinn, P.J., Wang, X. (eds) Lipids in Health and Disease. Subcellular Biochemistry, vol 49. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8831-5_1

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