Abstract
Visual scan paths are a pattern of foveal fixations and voluntary saccades produced when an individual views an image. These scan paths have repeatedly been shown to be abnormal in patients with schizophrenia. Most clinical scan path studies have focused on the investigation of eye movements to images of social scenes, or most commonly, of faces. While healthy participants scan face images extensively, particularly the eyes and mouth, patients with schizophrenia demonstrate restricted scanning of these images. In other words, patients with schizophrenia exhibit fewer fixations, longer fixation duration, longer saccade duration and peak velocity, and smaller saccade amplitude compared with healthy controls. However, recent evidence has shown that this abnormality is not specific to faces but can be observed to other image types. In addition, it has been shown that the spatial distribution of fixation locations is different in patients with schizophrenia compared to healthy controls and that this abnormal scanning behaviour extends to patients with bipolar disorder. A small study on healthy twins has provided preliminary evidence that the distribution of fixations may be genetically determined and may serve as a biomarker for schizophrenia and bipolar disorder.
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References
Manor BR, Gordon E. Defining the temporal threshold for ocular fixation in free- viewing visuocognitive tasks. J Neurosc Methods 2003;128:85–93.
Schyns PG, Olivia A. From blobs to boundary edges: Evidence for time— and spatial-scale-dependent scene recognition. Psychol Sci 1994;5:195–200.
Hollingworth A, Henderson JM. Accurate visual memory for previously attended objects and natural scenes. Journal of Experimental Psychology: Human Perception and Performance 2002;28:113–136.
Matin E. Saccadic suppression: A review and an analysis. Psychol Bull 1974;81:899–917.
Buswell GT. How people look at pictures: A study of the psychology of perception in art. Chicago: University of Chicago Press, 1935.
Yarbus AL. Eye movements and vision. New York: Plenum Press, 1967.
Noton D, Stark I. Eye movements and visual perception. Sci Am 1971;224:35–43.
Phillips ML, David AS. Understanding the Symptoms of Schizophrenia Using Visual Scan Paths. Br J Psychiatry 1994;165:673–675.
Phillips ML, David AS. Abnormal visual scan paths: a psy-chophysiological marker of delusions in schizophrenia. Schizophr Res 1998;29:235–245.
Latimer CR. Eye-movement data: Cumulative fixation time and cluster analysis. Behav Res Methods Instrum Comput 1988;20:437–430.
Bestelmeyer PEG, Tatler, B.W., Phillips, L.H., Fraser, G., Benson, P., & St.Clair, D. Global visual scanning abnormalities in schizophrenia and bipolar disorder. Schizophr Res 2006;87:212–222.
Bestelmeyer PEG, Tatler, B.W., Phillips, L.H., Benson, P., & St.Clair, D. Are temporal characteristics of visual scan paths heritable? Perception 2006;35:136.
Mannan SK, Ruddock KH, Wooding DS. Automatic control of saccadic eye movements made in visual inspection of briefly presented 2-D images. Spat Vis 1995;9:363–386.
Mannan SK, Ruddock KH, Wooding DS. The relationship between the locations of spatial features and those of fixa-tions made during visual examination of briefly presented images. Spat Vis 1996;10:165–188.
Tatler BW, Baddeley RJ, Gilchrist ID. Visual correlates of fixation selection: effects of scale and time. Vis Res 2005;45:643–659.
Gould TD, Gottesman II. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 2006;5:113–119.
Streit M, Wolwer W, Gaebel W. Facial-affect recognition and visual scanning behaviour in the course of schizophrenia. Schizophr Res 1997;24:311–317.
Loughland CM, Williams LM, Harris AW. Visual scanpath dysfunction in first-degree relatives of schizophrenia probands: evidence for a vulnerability marker? Schizophr Res 2004;67:11–21.
Walker-Smith GJ, Gale AG, Findlay JM. Eye movement strategies involved in face perception. Perception 1977;6:313–326.
Gordon E, Coyle S, Anderson J, et al. Eye movement response to a facial stimulus in schizophrenia. Biol Psychiatry 1992;31:626–629.
Gaebel W, Ulrich G, Frick K. Visuomotor performance of schizophrenic patients and normal controls in a picture viewing task. Biol Psychiatry 1987;22:1227–1237.
Loughland CM, Williams LM, Gordon E. Visual scanpaths to positive and negative facial emotions in an outpatient schizophrenia sample. Schizophr Res 2002;55:159–170.
Loughland CM, Williams LM, Gordon E. Schizophrenia and affective disorder show different visual scanning behavior for faces: A trait versus state-based distinction? Biol Psychiatry 2002;52:338–348.
Phillips ML, David AS. Visual scan paths are abnormal in deluded schizophrenics. Neuropsychologia 1997;35:99–105.
Williams LM, Loughland CM, Gordon E, Davidson D. Visual scanpaths in schizophrenia: is there a deficit in face recognition? Schizophr Res 1999;40:189–199.
Williams LM, Loughland CM, Green MJ, Harris AWF, Gordon E. Emotion perception in schizophrenia: an eye movement study comparing the effectiveness of risperidone vs. haloperidol. Psychiatry Res 2003;120:13–27.
Kojima T, Matsushima E, Ando K, et al. Exploratory Eye-Movements and Neuropsychological Tests in Schizophrenic-Patients. Schizophr Bull 1992;18:85–94.
Ryu H, Morita K, Shoji Y, Waseda Y, Maeda H. Abnormal exploratory eye movements in schizophrenic patients vs healthy subjects. Acta Neurol Scand 2001;104:369–376.
Green MJ, Williams LM, Hemsley DR. Cognitive theories of delusion formation: The contribution of visual scanpath research. Cogn Neuropsychiatry 2000;5:63–74.
Minassian A, Granholm E, Verney S, Perry W. Visual scanning deficits in schizophrenia and their relationship to executive functioning impairment. Schizophr Res 2005;74:69–79.
Manor BR, Gordon E, Williams LM, et al. Eye movements reflect impaired face processing in patients with schizophrenia. Biol Psychiatry 1999;46:963–969.
Russel TA, Green MJ, Simpson I, Coltheart M. Remediation of facial emotion perception in schizophrenia: Concomitant changes in visual attention. Schizophr Res 2008;103:248–256.
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Bestelmeyer, P.E.G. (2009). Visual Scanning Abnormalities as Biomarker for Schizophrenia. In: Ritsner, M.S. (eds) The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9464-4_15
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DOI: https://doi.org/10.1007/978-1-4020-9464-4_15
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