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Role of Aberrant Cell Cycle in the Growth and Pathogenesis of Glioblastoma

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Glioblastoma

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Abstract

Glioblastoma is the most malignant and unmanageable type of brain tumor with a high rate of mortality. Following cessation of developmental process in the central nervous system (CNS), only the glial cells retain their inherent ability to multiply. Hence, it is not surprising that most of the adult CNS tumors are of glial origin. One of the salient features of the glioblastoma progression is its capability of unlimited proliferation. The contribution of aberrant cell cycle to proliferation of glioblastoma and its pathogenesis has been extensively studied. This chapter attempts to correlate the formation of glial tumors with their progressive acquisition of genetic alterations, which make these progenitor cells predisposed to the mitogenic stimuli leading to gliomagenesis instead of gliogenesis. An attempt is made to correlate and unify the roles of divergent stimuli ranging from growth factors to epigenetic changes on the key signaling moieties such as non-histone tumor suppressors and ubiquitin ligases that affect the cell cycle control leading to the onset of aberrations in the cell cycle. These aberrations lead to uncontrolled cell growth, progression, and pathogenesis of glioblastomas.

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  1. Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Building 2, Room C11, 6439 Garners Ferry Road, Columbia, SC, 29209, USA

    Swapan K. Ray

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  1. Rajiv Janardhanan
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  2. Naren L. Banik
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  3. Swapan K. Ray
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Correspondence to Swapan K. Ray .

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  1. Dept. Neurosciences, Medical University of South Carolina, Jonathan Lucas St. 96 , Charleston, 29425, U.S.A.

    Swapan K. Ray

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Janardhanan, R., Banik, N.L., Ray, S.K. (2010). Role of Aberrant Cell Cycle in the Growth and Pathogenesis of Glioblastoma. In: Ray, S. (eds) Glioblastoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0410-2_6

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