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Blood Flow in an Out-of-Plane Aorto-left Coronary Sequential Bypass Graft

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Computational Cardiovascular Mechanics

Abstract

Coronary artery bypass graft (CABG) is a major therapy for ischemic heart disease which if left untreated can progress to failure of the heart. Restenosis, a leading cause of CABG, can be correlated with the geometric configuration and the hemodynamics of the graft. In this chapter we use computational fluid dynamics (CFD) to investigate the hemodynamics in a 3D out-of-plane sequential bypass graft model. Using a finite volume approach, quasi-steady flow simulations are performed at mid-ejection and at mid-diastole. Plots of velocity vectors, wall shear stress (WSS), and spatial WSS gradient (WSSG) distribution are presented in the aorto-left coronary bypass graft domain. Simulation results reveal a more uniform WSS and spatial WSSG distribution in the side-to-side (sequential graft) anastomosis configuration over the end-to-side (multiple graft) anastomosis. Results for the multiple bypass graft model show the peak magnitudes of the spatial WSSG are higher compared to the sequential bypass graft model. These findings suggest that sequential bypass grafting may be preferable over multiple bypass grafting to avoid non-uniformities of WSS.

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Acknowledgments

This research was supported in part by the National Institute of Health-National Heart, Lung, and Blood Institute Grant HL086400 and HL084529.

Author information

Authors and Affiliations

  1. Mathematics, Department of Science and Humanities, Hindustan University, Padur, Kelambakkam, Chennai, India

    Meena Sankaranarayanan

  2. Parkway College, 150168, Singapore, Singapore

    Dhanjoo N. Ghista

  3. School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore

    Leok Poh Chua

  4. Tan Yong Seng Heart, Lung & Vascular Surgery Pet Ltd, Mount Elizabeth Hospital, Singapore, Singapore

    Tan Yong Seng

  5. Mechatronics and Recording Channel Division, Data Storage Institute, Singapore, Singapore

    Kannan Sundaravadivelu

  6. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 46202, Indianapolis, IN, USA

    Ghassan S. Kassab

  7. Department of Biomedical Engineering, West Lafayette, 46202, Indianapolis, IN, USA

    Ghassan S. Kassab

  8. Department of Surgery, West Lafayette, 46202, Indianapolis, IN, USA

    Ghassan S. Kassab

  9. Department of Cellular and Integrative Physiology, West Lafayette, 46202, Indianapolis, IN, USA

    Ghassan S. Kassab

  10. Indiana Center for Vascular Biology and Medicine, IUPUI, West Lafayette, 46202, Indianapolis, IN, USA

    Ghassan S. Kassab

Authors
  1. Meena Sankaranarayanan
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  2. Dhanjoo N. Ghista
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  3. Leok Poh Chua
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  4. Tan Yong Seng
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  5. Kannan Sundaravadivelu
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  6. Ghassan S. Kassab
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Corresponding author

Correspondence to Meena Sankaranarayanan .

Editor information

Editors and Affiliations

  1. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Julius M. Guccione

  2. Purdue University Indianapolis, Indiana University, Barnhill Drive 635, Indianapolis, 46202, U.S.A.

    Ghassan S. Kassab

  3. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Mark B. Ratcliffe

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Sankaranarayanan, M., Ghista, D.N., Chua, L.P., Seng, T.Y., Sundaravadivelu, K., Kassab, G.S. (2010). Blood Flow in an Out-of-Plane Aorto-left Coronary Sequential Bypass Graft. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_17

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  • DOI: https://doi.org/10.1007/978-1-4419-0730-1_17

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0729-5

  • Online ISBN: 978-1-4419-0730-1

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