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The Neuropathology of Schizophrenia: Central Role for the Hippocampus?

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Advances in Schizophrenia Research 2009

Abstract

A change in conceptual thinking about the pathogenesis of schizophrenia has occurred over the past decades. It is now hypothesized that the disorder has its origin on brain developmental neuropathology. The so-called neurodevelopmental hypothesis proposes that schizophrenia is related to adverse conditions leading to abnormal brain development during the pre- or postnatal period. This consequently leads to long-term changes in brain structure and brain malfunction, predisposing in term to functional deficits and to symptoms that respond to antidopaminergic drugs (Weinberger 1996).

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University of Goettingen, von Siebold Str. 5, 37075, Goettingen, Germany

    Peter Falkai, Eleni Parlapani, Oliver Gruber & Andrea Schmitt

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  1. Peter Falkai
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  2. Eleni Parlapani
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  3. Oliver Gruber
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  4. Andrea Schmitt
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Correspondence to Peter Falkai .

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  1. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Wagner F. Gattaz

  2. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Geraldo Busatto

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Falkai, P., Parlapani, E., Gruber, O., Schmitt, A. (2010). The Neuropathology of Schizophrenia: Central Role for the Hippocampus?. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_7

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