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Targeting the PI3K/Akt/mTOR Pathway in AIDS-Associated Malignancies

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Molecular Basis for Therapy of AIDS-Defining Cancers

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Abstract

The PI3K/Akt pathway is highly activated in a wide variety of human cancers. Dysregulated PI3K signaling plays roles in many aspects of tumorigenesis including apoptotic resistance, uncontrolled proliferation, metastasis, and angiogenesis. AIDS-associated malignancies such as Kaposi’s sarcoma (KS) and non-Hodgkin lymphoma (NHL) display activated PI3K, Akt, and mTOR kinases and thus may be susceptible to treatment modalities that inhibit this important signaling pathway. In this chapter, we discuss the use of mTOR inhibitors to treat both KS and NHL.

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Acknowledgments

B.D. is a Leukemia & Lymphoma Society Scholar and a Burroughs Welcome Fund Investigator in Infectious Disease. Her work is supported by grants CA096500, DE18281, and HL083469 from the NIH.

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  1. Department of Microbiology and Immunology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA

    Blossom Damania Ph.D.

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  1. Blossom Damania Ph.D.
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Correspondence to Blossom Damania Ph.D. .

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  1. Lineberger Comprehensive, Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

    Dirk P. Dittmer

  2. Cancer Center, Memorial Sloan-Kettering, York Ave. 1275, New York, 10065, New York, USA

    Susan E. Krown

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Damania, B. (2010). Targeting the PI3K/Akt/mTOR Pathway in AIDS-Associated Malignancies. In: Dittmer, D., Krown, S. (eds) Molecular Basis for Therapy of AIDS-Defining Cancers. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1513-9_9

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