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Quality of Life in Patients with HIV Infection and Liver Disease

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HIV and Liver Disease

Abstract

The presence of HIV infection, alone or in combination with other infections and diseases, can have a serious impact on a patient’s health and quality of life (QOL). According to the World Health Organization (WHO) Constitution of 1948, “Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity” [1]. Like the definition of health, the definition of QOL is broad and multidimensional, “[An] individual’s perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns” [2].

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References

  1. World Health Organization. Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference, New York, 19–22 June, 1946; signed on 22 July 1946 by the representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and entered into force on 7 April 1948. http://www.who.int/about/definition/en/print.html. Accessed 12 Apr 2010.

  2. The WHOQOL Group. The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41:1403–9.

    Article  Google Scholar 

  3. McDowell I. Measuring health: a guide to rating scales and questionnaires. 3rd ed. New York: Oxford University Press; 2006.

    Google Scholar 

  4. Whalen GF, Ferrans CE. Quality of life as an outcome in clinical trials and cancer care: a primer for surgeons. J Surg Oncol. 2001;77:270–6.

    Article  PubMed  CAS  Google Scholar 

  5. Shumaker SA, Ellis S, Naughton M. Assessing health-related quality of life in HIV disease: key measurement issues. Qual Life Res. 1997;6:475–80.

    Article  PubMed  CAS  Google Scholar 

  6. Szaflarski M, Ritchey PN, Leonard AC, Mrus JM, Peterman AH, Ellison CG, et al. Modeling the effects of spirituality/religion on patients’ perceptions of living with HIV/AIDS. J Gen Intern Med. 2006;21 suppl 5:S28–38.

    Article  PubMed  Google Scholar 

  7. Vetter TR. A primer on health-related quality of life in chronic pain medicine. Anesth Analg. 2007;104(3):703–18.

    Article  PubMed  CAS  Google Scholar 

  8. Eisen GM, Locke III GR, Provenzale D. Health-related quality of life: a primer for gastroenterologists. Am J Gastroenterol. 1999;94(8):2017–21.

    Article  PubMed  CAS  Google Scholar 

  9. O’Brien B, Gafni A. When do the ‘dollars’ make sense? Toward a conceptual framework for contingent valuation studies in health care. Med Decis Making. 1996;16:288–99.

    Article  PubMed  Google Scholar 

  10. Ryan M, Farrar M. Using conjoint analysis to elicit preferences for health care. BMJ. 2000;320:1530–3.

    Article  PubMed  CAS  Google Scholar 

  11. Beusterien KM, Dziekan K, Flood E, Harding G, Jordan JC. Understanding patient preferences for HIV medications using adaptive conjoint analysis: feasibility assessment. Value Health. 2005;8:453–61.

    Article  PubMed  Google Scholar 

  12. Nord E. The person-trade-off approach to valuing health care programs. Med Decis Making. 1995;15:201–8.

    Article  PubMed  CAS  Google Scholar 

  13. Drummond MF, Sculpher MJ, Torrance GW, O’Brien BJ, Stoddart GL. Methods for the economic evaluation of health care programmes. 3rd ed. New York: Oxford University Press; 2005.

    Google Scholar 

  14. Torrance GW. Social preference for health states. An empirical evaluation of three measurement techniques. Soc Econ Plan Sci. 1976;10:129–36.

    Article  Google Scholar 

  15. Tsevat J, Sherman SN, McElwee JA, Mandell KL, Simbartl LA, Sonnenberg FA, et al. The will to live among HIV-infected patients. Ann Intern Med. 1999;131:194–8.

    PubMed  CAS  Google Scholar 

  16. Feeny D, Furlong W, Boyle M, Torrance GW. Multi-attribute health status classification systems: health utilities index. Pharmacoeconomics. 1995;7:490–502.

    Article  PubMed  CAS  Google Scholar 

  17. Furlong W, Feeny D, Torrance GW, Goldsmith C, DePauw S, Boyle M, et al. Multiplicative multi-attribute utility function for the Health Utilities Index Mark 3 (HUI3) system: a technical report. 1998. McMaster University Centre for Health Economics and Policy Analysis Working Paper No. 98–11.

    Google Scholar 

  18. Group EQ. EuroQOL – a new facility for the measurement of health-related quality of life. Health Policy. 1990;16:199–208.

    Article  Google Scholar 

  19. Kind P. The EuroQOL instrument: an index of health-related quality of life. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. 2nd ed. Philadelphia: Lippincott-Raven; 1996.

    Google Scholar 

  20. Brazier J, Usherwood T, Harper R, Thomas K. Deriving a preference-based single index measure from the SF-36 health survey. J Clin Epidemiol. 1998;51:1115–28.

    Article  PubMed  CAS  Google Scholar 

  21. Brazier J, Roberts J, Deverill M. The estimation of a preference-based measure of health from the SF-26. J Health Econ. 2002;21:271–92.

    Article  PubMed  Google Scholar 

  22. Kaplan RM, Anderson JP. The general health policy model: an integrated approach. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. 2nd ed. Philadelphia: Lippincott-Raven; 1996.

    Google Scholar 

  23. Torrance GW, Feeny DH, Furlong WJ, Barr RD, Zhang Y, Wang Q. Multiattribute utility function for a comprehensive health status classification system: health utilities index mark 2. Med Care. 1996;34:702–22.

    Article  PubMed  CAS  Google Scholar 

  24. Shaw JW, Johnson JA, Coons SJ. US valuation of the EQ-5D health states. Development and testing of the D1 valuation model. Med Care. 2005;43:203–20.

    Article  PubMed  Google Scholar 

  25. Rivero-Arias O, Ouellet M, Gray A, Wolstenholme J, Rothwell PM, Luengo-Fernandez R. Mapping the modified Rankin Scale (mRS) measurement into the generic EuroQol (ED-5D) health outcome. Med Decis Making. 2010;30:341–54.

    Article  PubMed  Google Scholar 

  26. Reeve BB, Hays RD, Bjorner JB, Cook KF, Crane PK, Teresi JA, et al. Psychometric evaluation and calibration of health-related quality of life item banks: plans for the Patient-Reported Outcomes Measurement Information System (PROMIS). Med Care. 2007;45(5 suppl 1):S22–31.

    Article  PubMed  Google Scholar 

  27. Revicki DA, Cella DF. Health status assessment for the twenty-first century: item response theory, item banking and computer adaptive testing. Qual Life Res. 1997;6:595–600.

    Article  PubMed  CAS  Google Scholar 

  28. Robinson FP. Measurement of quality of life in HIV disease. J Assoc Nurses AIDS Care. 2004;15(5 suppl):14S–9.

    Article  PubMed  Google Scholar 

  29. Galárraga O, Colchero MA, Wamai RG, Bertozzi SM. HIV prevention cost-effectiveness: a systematic review. BMC Public Health. 2009;18(9 suppl 1):S5.

    Google Scholar 

  30. Bayoumi AM, Zaric GS. The cost-effectiveness of Vancouver’s supervised injection facility. Can Med Assoc J. 2008;179:1143–51.

    Article  Google Scholar 

  31. Gold MR, Siegel JE, Russell LB, Weinstein MC, editors. Cost effectiveness in health and medicine. New York: Oxford University Press; 1996.

    Google Scholar 

  32. Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Med Care. 1992;30:473–83.

    Article  PubMed  Google Scholar 

  33. Ware Jr JE, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220–3.

    Article  PubMed  Google Scholar 

  34. Wu A, The Quality of Life Subcommittee of the AIDS Clinical Trial Group (ACTG) Outcomes Committee. ACTG QOL 601–602 (QOL 601–2) Health Survey Manual, 1999. https://www.fstrf.org/apps/cfmx/apps/actg/html/QOLForms/manualql601-2799.pdf. Accessed 7 Jun 2010.

  35. Hays RD, Cunningham WE, Cherbourne CD, Wilson IB, Wu AW, Cleary PD, et al. Health-related quality of life in patients with human immunodeficiency virus infection in the United States: results from the HIV Cost and Services Utilization Study. Am J Med. 2000;108:714–22.

    Article  PubMed  CAS  Google Scholar 

  36. Wu AW, Rubin HR, Mathews WC, Ware JE, Brysk LT, Hardy WD, et al. A health status questionnaire using 30 items from the medical outcomes study: preliminary validation in persons with early HIV infection. Med Care. 1991;29(8):786–98.

    Article  PubMed  CAS  Google Scholar 

  37. Wu AW, Hays RD, Kelly S, Malitz F, Bozzette SA. Applications of the medical outcomes study health-related quality of life measures in HIV/AIDS. Qual Life Res. 1997;6:531–54.

    Article  PubMed  CAS  Google Scholar 

  38. Wu AW, Revicki DA, Jacobson D, Malitz FF. Evidence for reliability, validity and usefulness of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Qual Life Res. 1997;6:481–93.

    Article  PubMed  CAS  Google Scholar 

  39. Mapi Research Trust. Patient-Reported Outcome and Quality of Life Instruments Database (ProQolid). http://www.mapi-trust.org/ressources/inhouseandexternaldatabases. Accessed 02 Jul 2010.

  40. Lubeck DP, Fries JF. Assessment of quality of life in early stage HIV-infected persons: data from the AIDS Time-oriented Health Outcome Study (ATHOS). Qual Life Res. 1997;6:494–506.

    Article  PubMed  CAS  Google Scholar 

  41. Holmes WC, Shea JA. A new HIV/AIDS-targeted quality of life (HAT-QoL) instrument: development, reliability, and validity. Med Care. 1998;36:138–54.

    Article  PubMed  CAS  Google Scholar 

  42. Clayson DJ, Wild DJ, Quarterman P, Duprat-Lomon I, Kubin M, Coons SJ. A comparative review of health-related quality-of-life measures for use in HIV/AIDS clinical trials. Pharmacoeconomics. 2006;24:751–65.

    Article  PubMed  Google Scholar 

  43. Garvie PA, Lawford J, Banet MS, West RL. Quality of life measurement in paediatric and adolescent populations with HIV: a review of the literature. Child Care Health Dev. 2009;25:440–53.

    Article  Google Scholar 

  44. Gralnek IM, Hays RD, Kilbourne A, Rosen HR, Keeffe EB, Artinian L, et al. Development and evaluation of the liver disease quality of life instrument in persons with advanced, chronic liver disease – the LDQOL 1.0. Am J Gastroenterol. 2000;95:3552–65.

    PubMed  CAS  Google Scholar 

  45. Ware Jr JE, Bayliss MS, Mannocchia M, Davis GL, and the International Hepatitis Interventional Therapy Group. Health-related quality of life in chronic hepatitis C: impact of disease and treatment response. Hepatology. 1999;30:550–5.

    Article  PubMed  Google Scholar 

  46. Kanwal F, Gralnek IM, Hays RD, Dulai GS, Brennan MR, Spiegel BMR, et al. Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample. Am J Gastroenterol. 2005;100:1984–94.

    Article  PubMed  Google Scholar 

  47. Fleming CA, Christiansen D, Nunes D, Heeren T, Thornton D, Horsburgh Jr CR, et al. Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection. Clin Infect Dis. 2004;38:572–8.

    Article  PubMed  Google Scholar 

  48. Henderson WA, Schlenk EA, Kim KH, Hadigan CM, Martino AC, Sereika SM, et al. Validation of the MOS-HIV as a measure of health-related quality of life in persons living with HIV and liver disease. AIDS Care. 2010;22(4):483–90. doi: 10.1080/09540120903207292 http://dx.doi.org/10.1080/09540120903207292.

  49. Tengs TO, Lin TH. A meta-analysis of utility estimates for HIV/AIDS. Med Decis Making. 2002;22:475–81.

    Article  PubMed  Google Scholar 

  50. Bult JR, Hunink MGM, Tsevat J, Weinstein MC. Heterogeneity in the relationship between the time tradeoff and Short Form-36 for HIV-infected and primary care patients. Med Care. 1998;36:523–32.

    Article  PubMed  CAS  Google Scholar 

  51. Bryce CL, Angus DC, Switala J, Roberts MS, Tsevat J. Health status vs. utilities of patients with end-stage liver disease. Qual Life Res. 2004;13:773–82.

    Article  PubMed  Google Scholar 

  52. Mrus JM, Yi MS, Freedberg KA, Wu AW, Zackin R, Gorski H, et al. Utilities derived from visual analog scale scores in patients with HIV/AIDS. Med Decis Making. 2003;23:414–21.

    Article  PubMed  Google Scholar 

  53. Nosyk B, Sun H, Bansback N, Guh DP, Barnett P, Bayoumi A, et al. The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. Qual Life Res. 2009;18:815–24.

    Article  PubMed  Google Scholar 

  54. Anderson JP, Kaplan RM, Coons SJ, Schneiderman LJ. Comparison of the Quality of Well-being Scale and the SF-36 results among two samples of ill adults: AIDS and other illnesses. J Clin Epidemiol. 1998;51:755–62.

    Article  PubMed  CAS  Google Scholar 

  55. Braithwaite RS, Goulet J, Kudel I, Tsevat J, Justice AC. Quantifying the decrement in utility from perceived side effects of combination antiretroviral therapies in patients with HIV. Value Health. 2008;11:975–9.

    Article  PubMed  Google Scholar 

  56. Mrus JM, Schackman BR, Wu AW, Freedberg KA, Tsevat J, Yi MS, et al. Variations in self-rated health among patients with HIV infection. Qual Life Res. 2006;15:503–14.

    Article  PubMed  Google Scholar 

  57. Tsevat J, Leonard AC, Szaflarski M, Sherman SN, Cotton S, Mrus JM, et al. Change in quality of life after being diagnosed with HIV: a multicenter longitudinal study. AIDS Patient Care STDS. 2009;23:931–7.

    Article  PubMed  Google Scholar 

  58. Groessl EJ, Weingart KR, Kaplan RM, Ho SB. Health-related quality of life in HCV-infected patients. Curr Hepat Rep. 2007;6:169–75.

    Article  Google Scholar 

  59. Sherman KE, Sherman SN, Chenier T, Tsevat J. Health values of patients with chronic hepatitis C infection. Arch Intern Med. 2004;164:2377–82.

    Article  PubMed  Google Scholar 

  60. Chong CA, Gulamhussein A, Heathcote EJ, Lilly L, Sherman M, Naglie G, et al. Health-state utilities and quality of life in hepatitis C patients. Am J Gastroenterol. 2003;98:630–8.

    Article  PubMed  Google Scholar 

  61. Björnsson E, Verbaan H, Oksanen A, Frydén A, Johansson J, Friberg S, et al. Health-related quality of life in patients with different stages of liver disease induced by hepatitis C. Scand J Gastroenterol. 2009;44:878–87.

    Article  PubMed  Google Scholar 

  62. Thein HH, Krahn M, Kaldor JM, Dore GJ. Estimation of utilities for chronic hepatitis C from SF-36 scores. Am J Gastroenterol. 2005;100:643–51.

    Article  PubMed  Google Scholar 

  63. Shmueli A. The SF-36 profile and health-related quality of life: an interpretative analysis. Qual Life Res. 1998;7:187–95.

    Article  PubMed  CAS  Google Scholar 

  64. Fryback DG, Lawrence WF, Martin PA, Klein R, Klein BE. Predicting quality of well-being scores from the SF-36: results from the beaver Dam health outcomes study. Med Decis Making. 1997;17:1–9.

    Article  PubMed  CAS  Google Scholar 

  65. Nichol MB, Sengupta N, Globe DR. Evaluating quality-adjusted life years: estimation of the health utility index (HUI2) from the SF-36. Med Decis Making. 2001;21:105–12.

    PubMed  CAS  Google Scholar 

  66. Mrus JM, Sherman KE, Leonard AC, Sherman SN, Mandell KL, Tsevat J. Health values of patients coinfected with HIV/Hepatitis C: are two viruses worse than one? Med Care. 2006;44:158–66.

    Article  PubMed  Google Scholar 

  67. Tillmann HL, Kaiser T, Claes C, Schmidt RE, Manns MP, Stoll M. Differential influence of different hepatitis viruses on quality of life in HIV positive patients. Eur J Med Res. 2006;11:381–5.

    PubMed  Google Scholar 

  68. Rockstroh JK, Mocroft A, Soriano V, Tural C, EuroSIDA Study Group. Hepatitis B and hepatitis C in the EuroSIDA cohort: influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005;192:992–1002.

    Article  PubMed  Google Scholar 

  69. Nader CM, Tsevat J, Justice AC, Mrus JM, Levin F, Kozal MJ, et al. Development of an electronic medical record-based clinical decision support tool to improve HIV symptom management. AIDS Patient Care STDS. 2009;23:521–9.

    Article  PubMed  Google Scholar 

  70. Tully MP, Cantrill JA. Subjective outcome measurement – a primer. Pharm World Sci. 1999;21(3):101–9.

    Article  PubMed  CAS  Google Scholar 

  71. Edelen MO, Reeve BB. Applying item response theory (IRT) modeling to questionnaire development, evaluation, and refinement. Qual Life Res. 2007;16:5–18.

    Article  PubMed  Google Scholar 

  72. Hays RD, Anderson R, Revicki D. Psychometric considerations in evaluating health-related quality to life measures. Qual Life Res. 1993;2:441–9.

    Article  PubMed  CAS  Google Scholar 

  73. Younossi ZM, Guyatt G, Kiwi M, Boparai N, King D. Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease. Gut. 1999;45:295–300.

    Article  PubMed  CAS  Google Scholar 

  74. Two R, Verjee-Lorenz A, Clayson D, Dalal M, Grotzinger K, Younossi ZM. A methodology for successfully producing global translations of patient reported outcome measures for use in multiple countries. Value Health. 2010;13:128–31.

    Article  PubMed  Google Scholar 

  75. The Chronic Liver Disease Questionnaire-HCV (CLDQ-HCV). http://www.ispor.org/publications/value/vihsupplementary/vih13i1_two.asp. Accessed 14 May 2010.

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Correspondence to Cindy L. Bryce PhD .

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Bryce, C.L., Tsevat, J. (2012). Quality of Life in Patients with HIV Infection and Liver Disease. In: Sherman, K. (eds) HIV and Liver Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1712-6_22

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