Abstract
Patients with new-onset or recurrent dyspeptic symptoms, but without previous investigations (diagnostic procedures), primarily upper gastrointestinal (GI) endoscopy, are defined as having “uninvestigated dyspepsia.” Based on the results of performed diagnostic workup, patients are redefined as having organic (structural) or functional dyspepsia that subsequently requires appropriate specific management. Test-and-treat, empiric acid suppressive therapy, test-and-scope, and prompt endoscopy are diagnostic and therapeutic tools commonly applied in the management of uninvestigated dyspepsia. The choice of management strategy is determined by degree of possibility of underlying disease and cost effectiveness. Due to numerous randomized controlled trials (RCTs) that have compared these different strategies, the evidence base for the management of uninvestigated dyspepsia is one of the largest and most extensive ones, although RCTs have often been underpowered to observe plausible minor dissimilarities in symptom outcomes [1–8].
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Duvnjak, M., Gomerčić, M., Stojsavljević, S. (2011). Management of Uninvestigated Dyspepsia. In: Duvnjak, M. (eds) Dyspepsia in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1730-0_8
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