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Treatment of Diabetes with Encapsulated Islets

  • Chapter
Therapeutic Applications of Cell Microencapsulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 670))

Abstract

Cell encapsulation has been proposed for the treatment of a wide variety of diseases since it allows for transplantation of cells in the absence of undesired immunosuppression. The technology has been proposed to be a solution for the treatment of diabetes since it potentially allows a mandatory minute-to-minute regulation of glucose levels without side-effects. Encapsulation is based on the principle that transplanted tissue is protected for the host immune system by a semipermeable capsule. Many different concepts of capsules have been tested. During the past two decades three major approaches of encapsulation have been studied. These include (i) intravascular macrocapsules, which are anastomosed to the vascular system as AV shunt, (ii) extravascular macrocapsules, which are mostly diffusion chambers transplanted at different sites and (iii) extravascular microcapsules transplanted in the peritoneal cavity. The advantages and pitfalls of the three approaches are discussed and compared in view of applicability in clinical islet transplantation.

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Authors and Affiliations

  1. Pathology and Medical Biology, Section of Immunoendocrinology, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands

    Paul de Vos, Milica Spasojevic & Marijke M. Faas

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  1. Paul de Vos
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  2. Milica Spasojevic
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  3. Marijke M. Faas
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  1. Laboratory of Pharmacy and Pharmaceutical Technology, University of the Basque Country, Vitoria-Gasteiz, Spain

    José Luis Pedraz PHD  & Gorka Orive PhD  & 

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de Vos, P., Spasojevic, M., Faas, M.M. (2010). Treatment of Diabetes with Encapsulated Islets. In: Pedraz, J.L., Orive, G. (eds) Therapeutic Applications of Cell Microencapsulation. Advances in Experimental Medicine and Biology, vol 670. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5786-3_5

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