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Mechanisms of Skeletal Muscle Weakness

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Muscle Biophysics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 682))

Abstract

Skeletal muscle weakness is an important feature of numerous ­pathological conditions and it may also be a component in normal ageing. Decreased muscular strength can be due to decreased muscle mass and/or intrinsic defects in the muscle cells. In this chapter we will discuss decreased force production due to mechanisms intrinsic to skeletal muscle cells. We will mainly use data from mouse disease models to exemplify defects at various sites in the cellular activation-contraction pathway. We will show that depending on the underlying problem, muscle weakness can be due decreased Ca2+ release from the sarcoplasmic reticulum, reduced myofibrillar Ca2+ sensitivity and/or decreased ability of the cross-bridges to generate force.

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  1. Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden

    Håkan Westerblad

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  1. Håkan Westerblad
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  2. Nicolas Place
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  3. Takashi Yamada
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Correspondence to Håkan Westerblad .

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  1. McGill University, Pine Avenue West 475, Montreal, H2W 1S4, Québec, Canada

    Dilson E. Rassier

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Westerblad, H., Place, N., Yamada, T. (2010). Mechanisms of Skeletal Muscle Weakness. In: Rassier, D. (eds) Muscle Biophysics. Advances in Experimental Medicine and Biology, vol 682. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6366-6_16

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