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Biopsy Retrieval, Tissue Handling, Morphology, and Histopathological Characteristics

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Bladder Pain Syndrome

Abstract

The role of histopathology in the diagnosis of BPS/IC is primarily one of excluding other possible diagnoses. However, biopsy retrieval and histopathological examination may also be of value when it comes to diagnosing BPS/IC as specimens from classic IC, or BPS ESSIC type 3C, frequently display rather discriminative histopathological and immunohistochemical features. Various fixation and staining techniques are also discussed in the present chapter as well as the role of, and the immunohistochemical detection of, the mast cell in IC.

There has been emphasis on the possibility of a neurogenic nature of BPS/IC as well as theories that the condition may arise from autoimmune disturbances. These questions are also addressed herein.

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References

  1. Johansson SL, Ogawa K, Fall M. The pathology of interstitial cystitis. In: Sant GR, editor. Interstitial cystitis. Philadelphia: Lippincott-Raven; 1997. p. 143–52.

    Google Scholar 

  2. Hunner GL. Elusive ulcer of the bladder: further notes on a rare type of bladder ulcer with report of 25 cases. Am J Obstet. 1918;78:374–95.

    Google Scholar 

  3. Lepinard V, Saint-Andre JP, Rognon LM. Interstitial cystitis. Current aspects. J Urol (Paris). 1984;90(7):455–65.

    CAS  Google Scholar 

  4. Johansson SL, Fall M. Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol. 1990;143(6):1118–24.

    PubMed  CAS  Google Scholar 

  5. Johansson SL, Fall M. Pathology of interstitial cystitis. Urol Clin North Am. 1994;21(1):55–62.

    PubMed  CAS  Google Scholar 

  6. Collan Y, Alfthan O, Kivilaakso E, Oravisto KJ. Electron microscopic and histological findings on urinary bladder epithelium in interstitial cystitis. Eur Urol. 1976;2(5):242–7.

    PubMed  CAS  Google Scholar 

  7. Dixon J, Holm-Bentzen M, Gilpin C. Electrone microscopic investigation of the bladder urothelium and glycocalix in patients with interstitial cystitis. J Urol. 1986;135:621–5.

    PubMed  CAS  Google Scholar 

  8. Anderstrom CR, Fall M, Johansson SL. Scanning electron microscopic findings in interstitial cystitis. Br J Urol. 1989;63(3):270–5.

    Article  PubMed  CAS  Google Scholar 

  9. Elbadawi A, Light JK. Distinctive ultrastructural pathology of nonulcerative interstitial cystitis. Urol Int. 1996;56:137–62.

    Article  PubMed  CAS  Google Scholar 

  10. Galli SJ. New insights into “the riddle of the mast cells”: microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest. 1990;62(1):5–33.

    PubMed  CAS  Google Scholar 

  11. Enerbäck L, Rundquist I. DNA distribution of mast cell populations in growing rats. Histochemistry. 1981;71:521–31.

    Article  PubMed  Google Scholar 

  12. Hunt LW, Colby TV, Weiler DA, Sur S, Butterfield JH. Immunofluorescent staining for mast cells in idiopathic pulmonary fibrosis: quantification and evidence for extracellular release of mast cell tryptase [see comments]. Mayo Clin Proc. 1992;67(10):941–8.

    PubMed  CAS  Google Scholar 

  13. Qu Z, Liebler JM, Powers MR, Galey T, Ahmadi P, Huang XN, et al. Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am J Pathol. 1995;147:564–73.

    PubMed  CAS  Google Scholar 

  14. Stevens LR, Austen KF. Recent advances in the cellular and molecular biology of mast cells. Immunol Today. 1989;10:381–6.

    Article  PubMed  CAS  Google Scholar 

  15. Williams RM, Bienenstock J, Stead RH. Mast cells: the neuroimmune connection. Chem Immunol. 1995;61:208–35.

    Article  PubMed  CAS  Google Scholar 

  16. Keith IM, Jin J, Saban R. Nerve-mast cell interaction in normal guinea pig urinary bladder. J Comp Neurol. 1995;363(1):28–36.

    Article  PubMed  CAS  Google Scholar 

  17. Naukkarinen A, Harvima IT, Aalto ML, Harvima RJ, Horsmanheimo M. Quantitative analysis of contact sites between mast cells and sensory nerves in cutaneous psoriasis and lichen planus based on a histochemical double staining technique. Arch Dermatol Res. 1991;283(7):433–7.

    Article  PubMed  CAS  Google Scholar 

  18. Newson B, Dahlstrom A, Enerback L, Ahlman H. Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscience. 1983;10(2):565–70.

    Article  PubMed  CAS  Google Scholar 

  19. Peeker R, Enerbäck L, Fall M, Aldenborg F. Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol. 2000;163:1009–15.

    Article  PubMed  CAS  Google Scholar 

  20. Ochs RL, Stein Jr T, Peebles CL, Gittes RF, Tan EM. Autoantibodies in interstitial cystitis. J Urol. 1994;151(3):587–92.

    PubMed  CAS  Google Scholar 

  21. Oravisto KJ. Interstitial cystitis as an autoimmune disease. A review. Eur Urol. 1980;6:10–3.

    PubMed  CAS  Google Scholar 

  22. Silk MR. Bladder antibodies in interstitial cystitis. J Urol. 1970;103:307–9.

    PubMed  CAS  Google Scholar 

  23. Mattila J, Pitkanen R, Vaalasti T, Seppanen J. Fine-structural evidence for vascular injury in patients with interstitial cystitis. Virchows Arch A Pathol Anat Histopathol. 1983;398(3):347–55.

    Article  PubMed  CAS  Google Scholar 

  24. Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol. 1989;44:93–151.

    Article  PubMed  CAS  Google Scholar 

  25. Harrington DS, Fall M, Johansson SL. Interstitial cystitis: bladder mucosa lymphocyte immunophenotyping and peripheral blood flow cytometry analysis. J Urol. 1990;144(4):868–71.

    PubMed  CAS  Google Scholar 

  26. Christmas TJ, Rode J, Chapple CR, Milroy EJ, Turner-Warwick RT. Nerve fibre proliferation in interstitial cystitis. Virchows Arch A Pathol Anat Histopathol. 1990;416(5):447–51.

    Article  PubMed  CAS  Google Scholar 

  27. Hohenfellner M, Nunes L, Schmidt RA, Lampel A, Thuroff JW, Tanagho EA. Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis. J Urol. 1992;147(3):587–91.

    PubMed  CAS  Google Scholar 

  28. Palea S, Artibani W, Ostardo E, Trist DG, Pietra C. Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol. 1993;150(6):2007–12.

    PubMed  CAS  Google Scholar 

  29. Pang X, Marchand J, Sant GR, Kream RM, Theoharides TC. Increased number of substance P positive nerve fibres in interstitial cystitis. Br J Urol. 1995;75(6):744–50.

    Article  PubMed  CAS  Google Scholar 

  30. Goldstein M. Enzymes involved in the catalysis of catecholamine biosynthesis. In: Ubell RN, editor. Methods in neurochemistry. New York: Plenum Press; 1972. p. 317–40.

    Chapter  Google Scholar 

  31. Peeker R, Aldenborg F, Johansson SL, Li J-Y, Dahlström A, Fall M. Increased tyrosine hydroxylase immunoreactivity in bladder tissue from patients with classic and nonulcer interstitial cystitis. J Urol. 2000;163:1112–5.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Sahlgrenska University Hospital, Gothenburg, 413 455, Sweden

    Christina Kåbjörn-Gustafsson

  2. Department of Urology, Sahlgrenska University Hospital, Bruna Straket 11, Gothenburg, 413 455, Sweden

    Ralph Peeker

Authors
  1. Christina Kåbjörn-Gustafsson
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  2. Ralph Peeker
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Corresponding author

Correspondence to Christina Kåbjörn-Gustafsson .

Editor information

Editors and Affiliations

  1. University of Copenhagen, Department of Urology, Herlev Hospital, Herlev, 2730, Denmark

    Jørgen Nordling

  2. University Hospital Antwerp, Department of Urology, and Antwerp University, Edegem, 2650, Belgium

    Jean Jacques Wyndaele

  3. and Internal Medicine, Erasmus MC,, Departments of Immunology, University Medical Center Rotterdam, Rotterdam, 3141 XW, Netherlands

    Joop P. van de Merwe

  4. Koege Hospital, Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, 4600, Denmark

    Pierre Bouchelouche

  5. Department Obstetrics and Gynecology, Department of Urogynecology S.Carlo-IDI, Catholic University, Rome, 00165, Italy

    Mauro Cervigni

  6. Institute of Clinical Sciences, Department of Urology, Sahlgrens Academy at University of Gothenburg, Göteborg, 41345, Sweden

    Magnus Fall

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Kåbjörn-Gustafsson, C., Peeker, R. (2013). Biopsy Retrieval, Tissue Handling, Morphology, and Histopathological Characteristics. In: Nordling, J., Wyndaele, J., van de Merwe, J., Bouchelouche, P., Cervigni, M., Fall, M. (eds) Bladder Pain Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6929-3_16

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  • DOI: https://doi.org/10.1007/978-1-4419-6929-3_16

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-6928-6

  • Online ISBN: 978-1-4419-6929-3

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