Abstract
On the basis of the structural characteristics of the 5’-flanking regions of genes encoding the two DNA repair-related enzymes, poly(ADP-ribose) polymerase and DNA polymerase beta, one may suggest that they can be active housekeeping genes (1, 2). The two enzymes are similarly distributed in a number of mouse tissues (3). This indicates that in some circumstances poly(ADP-ribose) polymerase and DNA polymerase beta can possibly be coexpressed. We have shown recently that poly(ADP-ribose) polymerase is induced in proliferating cells during G1/S phase (4, 5). An increase of DNA polymerase beta activity was shown to occur in mitogen-treated peripheral mononuclear cells (PBMC) after DNA synthesis (6). Data on the expression of DNA polymerase beta gene in proliferating cells are so far not available.
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Menegazzi, M. et al. (1992). Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_14
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DOI: https://doi.org/10.1007/978-1-4419-8718-1_14
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6456-9
Online ISBN: 978-1-4419-8718-1
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