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The Puromycin-Sensitive Aminopeptidase

Role in neurological, reproductive, immunological and proliferative disorders

  • Chapter
Aminopeptidases in Biology and Disease

Part of the book series: Proteases in Biology and Disease ((PBAD,volume 2))

Abstract

The puromycin-sensitive aminopeptidase (ApPS) was identified as the major enkephalin-degrading activity in brain, but has subsequently been implicated in a variety of cellular functions. In addition to regulating the concentration of neuropeptides, ApPS has been suggested to be involved in reproductive function, cell cycle regulation, regulation of apoptosis, general protein turnover, and antigen presentation. Its involvement in these cellular functions has led to its implication in a number of diseases and disorders, including reproductive infertility, adult-onset dementia, disorders of anxiety and nociception, cancer and metastasis, growth defects, liver failure, and disorders of immune function. While its involvement in these disease states is evident, the precise pathology of these conditions is unknown, making the identification of physiological substrates of ApPS and the development of specific ApPS inhibitors an attractive field of study.

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Authors and Affiliations

  1. Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Michael W. Thompson

  2. Department of Molecular and Cellular Biochemistry, School of Medicine, Chandler Medical Center, University of Kentucky, Lexington, KY, USA

    Louis B. Hersh

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  1. Michael W. Thompson
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  2. Louis B. Hersh
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Editors and Affiliations

  1. University of Leeds, Leeds, UK

    Nigel M. Hooper

  2. Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel

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Thompson, M.W., Hersh, L.B. (2004). The Puromycin-Sensitive Aminopeptidase. In: Hooper, N.M., Lendeckel, U. (eds) Aminopeptidases in Biology and Disease. Proteases in Biology and Disease, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8869-0_1

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