Abstract
Six different resin adsorbents were prepared and developed for in vitro studies and clinical trials to remove pathogenic toxins in various diseases by hemoperfusion. NK-I07 is a resin with a high surface area of lO86m2/g and was used clinically to detoxify drug overdose patients. Macroporous resin NK110 has a large pore diameter of 160Aand can remove high levels of bilirubin in hyperbilirubinemia patients. DNA immobilized on carbonized resin can selectively remove pathogenic DNA antibodies in sy stemic lupus erythematosus patients by whole blood hemoperfusion. Single strain DNA immobilized on carbonized resin can also remove the rheumatoid factor effectively in patients. Amphiphilic adsorbent containing cholesterol and sulfonic acid groups can adsorb up to 90.46%, 54.00% and 66.96% ofLDL, TC and TG in vitro. Tumor necrosi s factor can be removed effectively from plasma by macroporous resins and polypeptide ligand linked to resin bead carriers.
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References
Fu, C.X.; Yu, Y.T.; Chen, C.Z., 2000, A Novel Immunoadsorbent for Rheumatoid Arthritis Therapy Preparation and Efficacy Evaluation. Art. Cells, Blood Subs. and Immob. Biotech. 28(5) 409
Grob, D.; Simpson, D.; Mitsumoto, H., 1995, Neurology 45 (2) 338
Giorgio Fassina, Giovanni Cassani, Angelo Cortri, 1992, Binding of Human Tumor Necrosis Factor (to Multimeric Complementary Peptides. Archives of Biochemistry and Biophysics, 296 (1): 137–143
Joseph P, Balint, Jr. 1996, Immune Modulation Associated with Extracorporeal Immunoadsorption Treatments Utilizing Protein A/Silica Columns. Artificial Organs, 20 (8) 906
Kong, D.L.; Chen, C.Z.; Lin, E.F.; Yu Y.T., 1998, Clinical Trials of Type I and In vitro Studies of Type II Immunoadsorbents for Systemic Lupus Erythematosus Therapy. Artificial Organs 22 (8):644–650
Paul J. Soltys, Mark R. Etzel, 1998, Equilibrium Adsorption of LDL and Gold Immunoconjugates to Affinity Membranes Containing PEG Spacers. Biomaterials 21:2000 37–38
Rosenbaum, J.L., 1978, Experience with Resin Hemoperfusion, in: Artificial Kidney, Artificial Liver and Artificial Cells (ed. Chang TMS). Pleum Press, New York
Terman, D.S.; Buffalot, et al., 1979, Extracorporeal Immunoadsorption: Initial Experience in Human Systemic Lupus Erythematosus, Lancet II:824
US Patent, Yu et al., 2001, US No: 6, 262, 172 Bl Jul. 17
Wang, S.Q; Yu, Y.T.; Cui, T.; C, Y., 2002, Cellulose amphiphilic adsorbent for the removal of low density lipoprotein. Art. Cells, Blood Subs. and Immob. Biotech., 30(4) 307–308
Wei, J.; Yu, Y.T., 2001, Macroporous Resin Adsorbent for the Removal of Necrosis Tumour Factor. Chemical Journal of Chinese Universities. 22 (11) 1843
Yang Y.; Yu, Y.T.; Song, J.C., et al 1988, A New Immune Adsorbent for Hemoperfusion in SLE Therapy: A Clinical Trial. Artificial Organs, 12 (5): 444–446
Yatzidis, H. et al., 1965, Treatment of Severe Barbiturate Poisoning, Lancet 2, 216
Zimmermann, M.; Busch, K.; Kuln, S., et al., 1999, Endotoxin Adsorbent Based on Immobilized Human Serum Albumin. Clin Chem Lab. Med, (3) 37
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© 2003 Springer Science+Business Media New York
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Yao-Ting, Y. (2003). Preparation and Clinical Trials of Bioadsorbents in Blood Purification. In: Hwang, N.H.C., Woo, S.LY. (eds) Frontiers in Biomedical Engineering. Topics in Biomedical Engineering International Book Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8967-3_11
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DOI: https://doi.org/10.1007/978-1-4419-8967-3_11
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