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Nitric Oxide, Oxygen Radicals

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Immunobiology of Organ Transplantation

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Abstract

Nitric oxide (NO) is one of the first gases discovered by Joseph Priestley in 1772. For more than 200 years, it was considered mainly as an environmental pollutant and product of bacterial metabolism. In 1980, Furchgott and Zawadzki reported a substance released from endothelial cells which is responsible for the relaxation of arterial smooth muscle by acetylcholine’. They named this substance endothelium-derived relaxing factor (EDRF). EDRF was proven to be NO in the late 1980s2-4. Since NO is known to be generated in many different mammalian cells, a deluge of articles has implicated this ubiquitous molecule in a wide variety of regulatory mechanisms ranging from vascular tone to neurotransmissions. NO is also involved in nonspecific immunity and participates in the complex mechanism of tissue injury, acting as a major mediator of inflammation-related processes6,7

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  1. Department of Surgery, University of Pittsburgh, PA, USA

    Shinichi Kanno, Larry L. Shears II & Timothy R. Billiar

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  1. Shinichi Kanno
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  1. Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana

    David S. Wilkes M.D. (Calvin H. English Professor of Medicine) (Calvin H. English Professor of Medicine)

  2. Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin

    William J. Burlingham Ph.D. (Associate Professor) (Associate Professor)

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Kanno, S., Shears, L.L., Billiar, T.R. (2004). Nitric Oxide, Oxygen Radicals. In: Wilkes, D.S., Burlingham, W.J. (eds) Immunobiology of Organ Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8999-4_26

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  • DOI: https://doi.org/10.1007/978-1-4419-8999-4_26

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