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On Synaptic Plasticity: Modelling Molecular Kinases involved in Transmitter Release

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Artificial Neural Networks in Medicine and Biology

Part of the book series: Perspectives in Neural Computing ((PERSPECT.NEURAL))

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Abstract

The neurotransmitter release depends, in principal, on two neuronal events. One is the influx of Calcium in the active zone due to polarization, and the other is the amount of fusion available neurotransmitter vesicles. We state a model of the phosphorylation of the Synapsins (I and II), which creates a pool of fusion available vesicles. The exocytosis of vesicles is stated by Calcium on and off rates, modelling the complex of the fusion pore. The aim here is to model paired pulse facilitation due to phosphorylation of the Synapsins, and post-tetanic potentiation due to increased kinetic activity of the cAMP complex. In addition we show that the regulation of fusion competent vesicles in post-tetanic potentiation is highly correlated to Calcium residues released by organelles, i.e Calcium buffering.

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Author information

Authors and Affiliations

  1. Dept. of Computer Science, Bioinformatics Group, University of Skövde, Skövde, Sweden

    Dan Lundh

  2. Dept. of Computer Science, University of Exeter, Exeter, England

    Ajit Narayanan

Authors
  1. Dan Lundh
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  2. Ajit Narayanan
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Editor information

Editors and Affiliations

  1. Department of Philosophy, Göteborg University, Box 200, SE-405 30, Göteborg, Sweden

    Helge Malmgren BA, PhD, MD

  2. Department of Electrical Engineering, Linköping University, SE-585 83, Linköping, Sweden

    Magnus Borga MSc, PhD

  3. Department of Computer Science, University of Skövde, PO Box 408, SE-541 28, Skövde, Sweden

    Lars Niklasson BSc, MSc, PhD

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© 2000 Springer-Verlag London

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Lundh, D., Narayanan, A. (2000). On Synaptic Plasticity: Modelling Molecular Kinases involved in Transmitter Release. In: Malmgren, H., Borga, M., Niklasson, L. (eds) Artificial Neural Networks in Medicine and Biology. Perspectives in Neural Computing. Springer, London. https://doi.org/10.1007/978-1-4471-0513-8_42

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  • DOI: https://doi.org/10.1007/978-1-4471-0513-8_42

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-289-1

  • Online ISBN: 978-1-4471-0513-8

  • eBook Packages: Springer Book Archive

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