Abstract
Although there has been a fairly clear understanding of what is meant by ‘osteoporosis’ for many years, there is some potential for confusion with the terms currently in use. Collins (1966) considered osteoporosis to be a generalised form of atrophy of bone, while reserving the actual term ‘bone atrophy’ for a more localised process, such as might occur in a paralysed limb. The term ‘localised osteoporosis’ is, however, frequently used to describe the changes in disused limbs or around severely arthritic joints. Sissons (1955) defined osteoporosis as a structural change in bone in which the supporting tissue is reduced in amount while remaining highly mineralised, and McLean and Urist (1961) thought in terms of increased bone porosity. The current general definition is of a disorder in which there is a diminution of bone mass without detectable differences from normal in the relative proportions of mineralised and non-mineralised matrix (Figs. 8.1, 8.2). Many workers prefer to use the term ‘osteopenia’ to describe this state of affairs and to reserve ‘osteoporosis’ for those cases of osteopenia in which there is actual or potential mechanical failure of bone. There is no general agreement as to the definition of either term and no difference in meaning is implied in the following account, though this might entail a more loose use of words than many would prefer.
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References
Aitken JM, Hart DM, Lindsay R (1973) Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. Br Med J 3:515–518
Alffram PA, Bauer GCH (1962) Epidemiology of fracture of the forearm. J Bone Joint Surg [Am] 44:105–114
Aloia JF, Cohn SH, Babu T, Abesamis C, Kalici N, Ellis K (1978a) Skeletal mass and body composition in marathon runners. Metabolism 27:1793–1796
Aloia JF, Stanton HC, Ostumi JA, Cane R, Ellis K (1978b) Prevention of involutional bone loss by exercise. Ann Intern Med 89:356–358
Avioli LV (1981) Post-nienopausal osteoporosis: prevention versus cure. Fed Proc 40:2418–2422
Avioli LV, McDonald JE, Lee SW (1965) The influence of age on the intestinal absorption of 47-Ca in post menopausal osteoporosis. J Clin Invest 44:1960–1967
Bhandarkar SD, Nordin BEC (1962) Effect of low-calcium diet on urinary calcium in osteoporosis. Br Med J I:145–147
Bird HA (1979) Bone biopsy in the investigation of bone pain and fractures. Rheumatol Rehabil 18:38–42
Bordier PHJ, Miravet L, Hioco D (1973) Young adult osteoporosis. Clin Endocrinol Metab 2:272–292
Bouillon R, Geusens P, Dequeker J, De Moor P (1979) Parathyroid function in primary osteoporosis. Clin Sci 57:167–171
Boukhris R, Becker KL (1973) The inter-relationship between vertebral fractures and osteoporosis. Clin Orthop 90:209–216
Boyce BF, Courpron P, Meunier PJ(1978) Parathyroid function in primary osteoporosis. Metab Bone Dis Relat Res 1:35–38
Brenton DP, Dent CE (1976) Idiopathic juvenile osteoporosis. In: Bickel H, Stern J (eds) Inborn errors of calcium and bone metabolism. MTP Press, Lancaster, pp 222–238
Bressot C, Meunier PJ, Chapuy MC, Lejeune E, Edouard C, Darby AJ (1979) Histomorphometric profile, pathophysiology and reversibility of corticosteroid-induced osteoporosis. Metab Bone Dis Relat Res 1:303–311
Brunning RO, Parkin JL, McKenna RW, Risdall R, Rosai J (1983) Systemic mastocytosis. Extra-cutaneous manifestations. Am J Surg Pathol 7:425–438
Bullamore JR, Gallagher JC, Wilkinson R, Nordin BEC, Marshall DH (1970) Effect of age on calcium absorption. Lancet II: 535–537
Cameron JR, Sorenson J (1963) Measurement of bone mineral in vivo: an improved method. Science 142:230–232
Caniggia A, Gennari C, Borrelo G (1970) Intestinal absorption of calcium-47 after treatment with oral oestrogen-gestogens in senile osteoporosis. Br Med J 4:30–32
Caniggia A, Nuti R, Lore F, Vattimo A (1981) Pathophysiology of the adverse effects of glucoactive corticosteroids on calcium metabolism in man. J Steroid Biochem 15:153–161
Cann CE, Genant HK, Ettinger B, Gordon GS (1980) Spinal mineral loss in oophorectomized women. JAMA 244.2056–2059
Chesnut CH III, Baylink DJ, Sisom K, Nelp WB, Roos BA (1980) Basal plasma immunoreactive calcitonin in post-menopausal osteoporosis. Metabolism 20:559–562
Collins DH (1966) The pathology of bone. Butterworths, London
Condon JR, Nassim JR, Hilbe A, Millard EJC, Stainthorpe EM (1970) Calcium and phosphorus metabolism in relation to lactose tolerance. Lancet I:1027–1029
Courpron P, Meunier P, Bressot C, Giroux JM (1976) Amount of bone in iliac crest biopsy. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 39–53
Courpron P, Lepire P, Arlot M, Lips M, Meunier PJ (1980) Mechanisms underlying the reduction in age of the mean wall thickness of trabecular basic structure unit (BSU) of human iMac bone. In: Jee WSS, Parfitt AM (eds) Bone histomorphometry. 3rd international workshop. Metab Bone Dis Relat Res 2(Suppl): 323–329
Crilly R, Horsman A, Marshall DH, Nordin BEC (1979) Prevalence, pathogenesis and treatment of postmenopausal osteoporosis. Aust NZ J Med 9:24–30
Crilly RG, Marshall DH, Horsman A, Nordin BEC, Peacock M (1983) Corticosteroid osteoporosis. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciphnary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 153–158
Cundy T, Heynen G, Ackroyd C, Kissin M, Kirby R, Kanis JA (1978) Plasma-calcitonin in women. Lancet II:158–159
Dalen N, Olssen KE (1974) Bone mineral content and physical activity. Acta Orthop Scand 45:170–174
Darby AJ (1981) Bone formation and resorption in post-menopausal osteoporosis. Lancet II: 536
Darby AJ, Meunier PJ (1981) Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis. Calcif Tissue Int 33:199–204
Davies M, Mawer EB, Adams PH (1977) Vitamin D metabolism and the response to 1,25- dihydroxycholecalciferol in osteoporosis. J Clin Endocrinol Metab 45:199–208
Deftos LJ, Weisman MH, Williams GW, Karpf DB, Frumar AM, Davidson BJ, Parthemore JG, Judd HL (1980) Influence of age and sex on plasma calcitonin in human beings. N Engl J Med 302:1351–1353
Dent CE (1977) Osteoporosis in childhood. Postgrad Med J 53:450–456
Dent CE, Friedman M (1965) Idiopathic juvenile osteoporosis. Q J Med 34:177–210
Dent CE, Watson L (1966) Osteoporosis. Postgrad Med J 42(Suppl): 583–608
Dent CE, Engelbrecht HE, Godfrey RC (1968) Osteoporosis of lumbar vertebrae and calcification of abdominal aorta in women living in Durban. Br Med J 4:76–79
Donaldson CL, Hulley SB, Vogel JM, Hattner RS, Bayers JH, McMillian DE (1970) Effect of prolonged bed rest on bone mineral. Metabolism 19:1071–1084
Doyle FH, Gutteridge DH, Joplin GF, Fraser R (1967) An assessment of radiological criteria used in the studies of spinal osteoporosis. Br J Radiol 40:241–250
Draper HH, Scythes CA (1981) Calcium, phosphorus and osteoporosis. Fed Proc 40:2434–2438
Engh G, Bollet AJ, Hardin G, Parson W (1968) Epidemiology of osteoporosis. II Incidence of hip fractures in mental institutions. J Bone Joint Surg [Am] 50:557–562
Epker BN (1970) Studies on bone turnover and balance in the rabbit. I Effects of hydrocortisone. CMn Orthop 72:315–326
Fallon MD, Whyte MP, Teitelbaum SL (1981) Systemic mastocytosis associated with generalised osteopenia: histopathological characterization of the skeletal lesion using undecalcified bone from two patients. Human Pathol 12:813–820
Fallon MD, Whyte MP, Craig RB, Teitelbaum SL (1983) Mast cell proliferation in postmenopausal osteoporosis. Calcif Tissue Int 35:29–31
Frame B, Nixon RK (1968) Bone marrow mast cells in osteoporosis of aging. N Engl J Med 279:626–630
Franchimont P, Heynen G (1976) Parathormone and calcitonin radioimmunoassay in various medical and osteoarticular disorders. Masson, Paris
Fucik RF, Kukreja SC, Hargis GK (1975) Effect of glucocorticoids on function of the parathyroid glands in man. J CMn Endocrinol Metab 40:152–155
Gallagher JC, Nordin BEC (1975) Effects of oestrogen and progestogen therapy on calcium metabolism in post menopausal women. Front Horm Res 3:150–176
Gallagher JC, Aaron J, Horsman A, Wilkinson R, Nordin BEC (1973) Corticosteroid osteoporosis. Clin Endocrinol (Oxf) 2:355–368
Gallagher JC, Aaron J, Horsman A, Marshall DH, Wilkinson R, Nordin BEC (1973) The crush fracture syndrome in post-menopausal women. Clin Endocrinol Metab 2:293–315
Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J Clin Invest 64:729–736
Gallagher JC, Riggs BL, DeLuca HF (1980a) Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 51:1359–1364
Gallagher JC, Riggs BL, Jerpbak CM, Arnaud CD (1980b) The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women. J Lab Clin Med 95:373–385
Gennari C, Bernini M, Nardi P, Fusi L, Francini G, Nami R, Montagnani M, Imsimbo B, Avioli LV (1983) Glucocorticoids: radiocalcium and radiophosphate absorption in man. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 75–80
Griffith GC, Nichols, G, Asher JD, Flanagan B (1965) Heparin in osteoporosis. JAMA 193:85–88
Hahn TJ, Boisseau VC, Avioli LV (1974) Effect of chronic corticosteroid administration on diaphyseal and metaphyseal bone mass. J Clin Endocrinol Metab 39:274–282
Hahn TJ, Halstead LR, Teitelbaum SL, Hahn BH (1979) Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration. J Clin Invest 64:655–665
Hahn TJ, Halstead LR, Baran DT (1981) Effects of short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 52:111–115
Harrison JE, McNeill KG, Sturtridge WC, Bailey TA, Murray TM, Williams C, Tam C, Fornasier V (1981) Three-year changes in bone mineral mass of post-menopausal osteoporotic patients based on neutron activation analysis of the central third of the skeleton. J Clin Endocrinol Metab 52:751–758
Hayflick L (1976) The cell biology of human aging. N Engl J Med 295:1302–1308
Heaney RP (1962) Radiocalcium metabolism in disuse osteoporosis in man. Am J Med 33:188–200
Heaney RP, Recker RR (1982) Effects of nitrogen, phosphomased caffeine on calcium balance in women. J Lab Clin Med 99:46–55
Heaney RP, Recker RR, Saville PD (1977) Calcium balance and calcium requirements in middle-aged women. Am J Clin Nutr 30:1603–1611
Heaney RP, Recker RR, Saville PD (1978a) Menopausal changes in calcium balance performance. J Lab Clin Med 92:953–963
Heaney RP, Recker RR, Saville PD (1978b) Menopausal changes in bone remodelling. J Lab Clin Med 92:964–970
Heath H III, Sizemore GW (1977) Plasma calcitonin in normal man: differences between men and women. J Clin Invest 60:1135–1140
Horsman A, Nordin BEC, Gallagher JC, Kirby PA, Milner RM, Simpson M (1977) Observations of sequential changes in bone mass in postmenopausal women ; a controlled trial of oestrogen and calcium therapy. Calcif Tissue Res 22:217–224
Jackson WPU (1958) Osteoporosis of unknown cause in younger people. Idiopathic osteoporosis. J Bone Joint Surg [Br] 40:420–441
Jaffe MD, Willis PW (1965) Multiple fractures associated with long-term sodium heparin therapy. JAMA 193:152–154
Jaworski ZFG, Leskove-Kiar M, Uthoff HK (1980) Effect of long term immobilisation on the pattern of bone loss in older dogs. J Bone Joint Surg [Br] 62:104–110
Jee WSS, Park HZ, Roberts WE (1970) Corticosteroid and bone. Am J Anat 129:477–481
Jones HH, Priest JD, Haynes WC, Trichenor CC, Nogel DA (1977) Humoral hypertrophy in response to exercise. J Bone Joint Surg [Am] 59:204–208
Jowsey J, Johnson KA (1972) Juvenile osteoporosis. Bone findings in seven patients. J Pediatr 81:511–517
Jowsey J, Riggs BL (1970) Bone formation in hypercorticolism. Acta Endocrinol (Copenh) 63:21–28
Kennedy AC, Lindsay R (1977) Bone involvement in rheumatoid arthritis. Clin Rheum Dis 3:403–420
Kinney VR, Tauxe WN, Dearing WH (1966) Isotopic tracer studies of intestinal calcium absorption. J Lab Clin Med 66:187–203
Klein M, Villanueva AR, Frost HM (1965) A quantitative histological study of rib from eighteen patients treated with adrenal cortical steroids. Acta Orthop Scand 35:171–184
Klein RG, Arnaud SB, Gallagher JC, DeLuca HF, Riggs BL (1977) Intestinal calcium absorption in exogenous hypercorticolism. Role of 25-hydroxyvitamin D and corticosteroid dose. J Clin Invest 60:253–259
Krawitt EL (1973) Ethanol inhibits intestinal calcium transport in rats. Nature 243:88–89
Krawitt EL (1974) Effect of acute ethanol administration on duodenal calcium transport. Proc Soc Exp Biol Med 146:406–408
Lafferty FW, Spencer GE, Pearson OH (1964) Effects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis. Am J Med 36:514–528
Lanyon LE, Rubin CT (1983) Regulation of bone mass in response to physical activity. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 51–61
Lawoyin S, Zerwekh JE, Glass K, Pak CYC (1980) Ability of 25-hydroxyvitamin D3 therapy to augment serum 1,25- and 24,25-dihydroxy-vitamin D in postmenopausal osteoporosis. J Clin Endocrinol Metab 50:593–596
Leong AS, Balasubramaniam P (1978) The estimation of dermal collagen in osteoporotic patients by a histomorphometric method. Pathology 10:365–371
Lerman S, Canterbury JM, Reiss E (1977) Parathyroid hormone and the hypercalcaemia of immobilization. J Clin Endocrinol Metab 45:425–428
Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC (1976) Long term prevention of postmenopausal osteoporosis by oestrogen. Lancet 1:1038–1042
Lips P, Courpron P, Meunier PJ (1978) Mean wall thickness of trabecular bone pockets in the human iliac crest: changes with age. Calcif Tissue Res 26:13–17
Lutwak L, Whedon GD, LaChance PA (1969) Mineral, electrolyte and nitrogen balance studies of the Gemini VII fourteen-day orbital space flight. J Clin Endocrinol Metab 29:1140–1156
Maassen AP (1952) The effect of desoxycorticosterone acetate (Doca) on body-growth and ossification. Acta Endocrinol (Copenh) 9:291–296
Mack PB, LaChance PC (1967) Effects of recumbency and space flight on bone density. Am J Clin Nutr 20:1194–1205
Maddison PJ, Bacon PA (1974) Vitamin D deficiency, spontaneous fractures and osteopenia in rheumatoid arthritis. Br Med J 4:433–435
Martin RB, Gutman W (1978) The effect of electric fields on osteoporosis of disuse. Calcif Tissue Res 25:23–27
Matkovic V, Kosteial K, Simonovic I, Buzina R, Brodarec A, Nordin BEC (1979) Bone status and fracture rates in two regions of Yugoslavia. Am J Clin Nutr 32:540–549
McConkey B, Fraser GB, Bligh AS, Whiteley H (1963) Transparent skin and osteoporosis. Lancet I:693–695
McLean FC, Urist MR (1961) Bone: an introduction to the physiology of skeletal tissue, 2nd edn. University of Chicago Press, Chicago
Meema S, Bunker ML, Meema HE (1975) Preventive effect of estrogen on postmenopausal bone loss. A follow up study. Arch Intern Med 135:1436–1440
Meunier P, Courpron P, Edouard C, Bernard J, Bringuier J, Vignon G (1973) Physiological senile involutional and pathological rarefaction of bone: quantitative and comparative histological data. Clin Endocrinol Metab 2:239–256
Meunier PJ, Courpron P, Edouard C, Alexandre C, Bressot C, Lips P, Boyce BF (1979) Bone histomorphometry in osteoporotic states. In: Barzel US (ed) Osteoporosis II. Grune and Stratton, New York, pp 27–47
Meunier PJ, Sellami S, Briancon D, Edouard C (1981) Histological heterogeneity of apparently idiopathic osteoporosis. In: DeLuca HF, Frost HM, Jee WSS, Johnson CC Jr, Parfitt AM (eds) Osteoporosis. Recent advances in pathogenesis and treatment. University Park Press, Baltimore, pp 293–301
Meunier PJ, Briancon D, Sellami S, Edouard C, Chavassieux P, Arlot P (1983) Dynamic bone histomorphometry in primary osteoporosis. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 67–73
Milhaud G, Benezech-Lefrevre M, Moukhtar MS (1978) Deficiency of calcitonin in age related osteoporosis. Biomedicine 29:272–276
Minaire P, Meunier P, Edouard C, Bernard J, Courpron P, Bourret J (1974) Quantitative histological data on disuse osteoporosis. Calcif Tissue Res 17:57–73
Moldawer M, Zimmerman SJ, Collins LC (1965) Incidence of osteoporosis in elderly whites and elderly negroes. JAMA 194:859–862
Morey ER, Baylink DJ (1978) Inhibition of bone formation during space flight. Science 201:1138–1341
Nagent de Deuxchaisnes C (1983) The pathogenesis and treatment of involutional osteoporosis. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis: A multidisciplinary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 291–333
Newcomer AD, Hodgson SF, McGill DB, Thomas PJ (1978) Lactose deficiency: prevalence in osteoporosis. Ann Intern Med 89:218–220
Newton-John HF, Morgan DB (1970) The loss of bone with age, osteoporosis and fractures. Clin Orthop 71:229–252
Ng KC, Revell PA, Beer M, Boucher BJ, Cohen RD, Currey HLF (1984) The incidence of metabolic bone disease, rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 43:370–377
Nilsson BE (1966) Post-traumatic osteopenia. A quantitative study of the bone mineral mass in the femur following fracture of the tibia in man using americum-241 as a photon source. Acta Orthop Scand 37(91): 1–55
Nilsson BE, Westlin NE (1971) Bone density in athletes. Clin Orthop 77:179–182
Nilsson BE, Westlin NE (1973) Changes in bone mass in alcoholics. Clin Orthop 90:229–232
Nilsson BE, Anderson SM, Havdrup T, Westlin NE (1978) Ballet-dancing and weightlifting-effects on BMC. Am J Roentgenol Radium Ther Nucl Med 131:541–542
Nordin BEC (1966) International patterns of osteoporosis. Clin Orthop 45:17–30
Nordin BEC, Aaron J, Spear R, Crilly RG (1981) Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis. Lancet II: 277–279
O’Driscoll S, O’Driscoll M (1980) Osteomalacia in rheumatoid arthritis. Ann Rheum Dis 39:1–6
Parfitt AM, Mathews C, Rao D, Frame B, Kleerekoper M, Villanueva AR (1981) Impaired osteoblast function in metabolic bone disease. In: DeLuca HF, Frost HM, Jee WSS, Johnson CC Jr, Parfitt AM (eds) Osteoporosis: recent advances in pathogenesis and treatment. University Park Press, Baltimore, pp 321–330
Peart KM, Ellis HA (1975) Quantitative observations on iliac bone marrow mast cells in chronic renal failure. J Clin Pathol 28:947–955
Perry HM, Fallon MD, Bergfeld M, Teitelbaum SL, Avioli LV (1982) Osteoporosis in young men: a syndrome of hypercalciuria and accelerated bone turnover. Arch Intern Med 142:1295–1298
Recker RR, Saville PD, Heaney RP (1977) Effect of estrogens and calcium carbonate on bone loss in post-menopausal women. Ann Intern Med 87:649–655
Riggs BL, Jowsey J, Kelly PJ, Jones JD, Maher FT (1969) Effect of sex hormones on bone in primary osteoporosis. J Clin Invest 48:1065–1072
Riggs BL, Arnaud CD, Jowsey J, Goldsmith RS, Kelly PJ (1973) Parathyroid function in primary osteoporosis. Clin Invest 52:181–184
Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III (1981) Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest 67:328–335
Saville PD (1965) Changes in bone mass with age and alcoholism. J Bone Joint Surg [Am] 47:492–499
Schenk RK, Merz WA (1969) Histologisch-morphometrische Untersuchungen über Altersatrophie und senile Osteoporose in der Spongiosa des Beckenkammes. Dtsch Med Wochenschr 94:206–208
Sissons HA (1955) The structural pathology of osteoporosis. Proc R Soc Med 48:566–578
Sissons HA, Hadfield GJ (1955) The influence of cortisone on the structure and growth of bone. J Anat 89:69–78
Smith R (1979) Idiopathic juvenile osteoporosis. Am J Dis Child 133:889–891
Smith R (1980) Idiopathic osteoporosis in the young. J Bone Joint Surg [Br] 62:417–427
Smith R, Sykes BC (1983) Osteogenesis imperfecta and idiopathic juvenile osteoporosis. In: Dixon A St J, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 133–135
Smith RW Jr, Rizek J (1966) Epidemiologic studies of osteoporosis in women of Puerto Rico and South Eastern Michigan with special reference to age, race, national origin and to other related or associated findings. Clin Orthop 45:31–48
Solomon L (1979) Bone density in ageing Caucasian and African populations. Lancet II: 1326–1330
Stevenson JC, White MG, Joplin GF, MacIntyre I (1982) Osteoporosis and calcitonin deficiency. Br Med J 285:1010–1011
Stinchfield AJ, Reidy JA, Barr JS (1949) Prediction of unequal growth of lower extremities in anterior poliomyelitis. J Bone Joint Surg [Am] 31:478–486
Teitelbaum SL, Rosenberg EM, Richardson CA, Avioli LV (1976) Histological studies of bone from normo- calcemic postmenopausal osteoporotic patients with increased circulating parathyroid hormone. J Clin Endocrinol Metab 42:537–543
Teotia M, Teotia SPS, Singh RK (1979) Idiopathic juvenile osteoporosis. Am J Dis Child 133:894–900
te Velde J, Vismans FJFE, Leenheers-Binnendijk L, Voz CJ, Smeenk D, Bijvoet OLM (1978) The eosinophilic fibrohistiocytic lesion of the bone marrow. A mastocellular lesion in bone disease. Virchows Arch [A] 377:277–285
Tilton FE, Degioanni TTC, Schneider VS (1980) Long term follow-up of Skylab bone demineralization. Aviat Space Environ Med 51:1209–1213
Urist MR, McLean FC (1957) Accumulation of mast cells in endosteum of bone of calcium-deficient rats. Arch Pathol 63:239–251
Uthoff HK, Jaworski ZFG (1978) Bone loss in response to long-term immobilisation. J Bone Joint Surg [Br] 60:420–429
Wahner HW, Riggs BL, Beabout JW (1977) Diagnosis of osteoporosis: usefulness of photon absorptiometry at the radius. J Nucl Med 18:432–437
Whedon GD, Lutwak L, Rambaut P, Whittle M, Leach C, Reid J, Smith M (1976) Effect of weightlessness on mineral metabolism: metabolic studies on Skylab orbital space flights. Calcif Tissue Res 21 (Suppl): 423–430.
Whiting SJ, Draper HH (1980) The role of sulfate in the calciuria of high protein diets in adult rats. J Nutr 110:212–222
Whyte MP, Bergfeld MA, Murphy WA, Avioli LV, Teitelbaum SL (1982) Postmenopausal osteoporosis. A heterogeneous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients. Am J Med 72:193–202
Wilson CR, Madsen M (1977) Dichromatic absorptiometry of vertebral bone mineral content. Invest Radiol 12:180–184
Young MM, Nordin BEC (1967) Effect of natural and artificial menopause on plasma and urinary calcium and phosphorus. Lancet II: 118–120
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Revell, P.A. (1986). Osteoporosis and Bone Atrophy. In: Pathology of Bone. Springer, London. https://doi.org/10.1007/978-1-4471-1377-5_8
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