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Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic Seminoma

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Germ Cell Tumours V

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Abstract

This paper presents data supporting the model that classical seminoma originates from a primordial germ cell/gonocyte in which maturation is blocked. Although spermatocytic seminoma might also originate from an embryonic germ cell, it retains the capacity to undergo further maturation, including partial meiosis. Moreover, we identified immunohistochemical markers helpful in the diagnosis of spermatocytic seminomas.

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Author information

Authors and Affiliations

  1. Pathology/Laboratory for Experimental Patho-Oncology, University Hospital Rotterdam/Daniel, Josephine Nefkens Institute, Erasmus University Rotterdam, Building Be, room 430b, Dr. Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands

    L. H. J. Looijenga, H. Stoop, R. J. H. L. M. van Gurp, R. de Krijger & J. W. Oosterhuis

Authors
  1. L. H. J. Looijenga
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  2. H. Stoop
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  3. R. J. H. L. M. van Gurp
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  4. R. de Krijger
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  5. J. W. Oosterhuis
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Editor information

Editors and Affiliations

  1. ICRF Cancer Medicine Research Unit, St James’s University Hospital, Leeds, UK

    Patricia Harnden MD, PhD, FRCPath, MBA

  2. Huddersfield Royal Infirmary, Huddersfield, UK

    Johnathan K. Joffe MB BS, MD, FRCP

  3. Yorkshire Centre for Cancer Treatments, Cookridge Hospital, Leeds, UK

    William G. Jones MB CHB, FRCR, DMRT

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© 2002 Springer-Verlag London Limited

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Looijenga, L.H.J., Stoop, H., van Gurp, R.J.H.L.M., de Krijger, R., Oosterhuis, J.W. (2002). Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic Seminoma. In: Harnden, P., Joffe, J.K., Jones, W.G. (eds) Germ Cell Tumours V. Springer, London. https://doi.org/10.1007/978-1-4471-3281-3_6

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  • DOI: https://doi.org/10.1007/978-1-4471-3281-3_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3283-7

  • Online ISBN: 978-1-4471-3281-3

  • eBook Packages: Springer Book Archive

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