Summary
Staphylococcal toxic shock syndrome toxin-1 (TSST-1) and streptococcal erythrogenic toxin A (ET A) exhibit potent immunoregulatory properties in addition to their lethal and toxic effects. Both toxins induced the production of high amounts of interleukin 1 and 2, tumor necrosis factor alpha, and interferon gamma. TSST-1 was also shown to induce the release of tumor necrosis factor beta and that of the hemopoietic growth factors: interleukin 3, M-CSF and GM-CSF.
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Alouf, J.E. (1990). Immunomodulating Toxins and Tumor Necrosis Factors. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_12
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DOI: https://doi.org/10.1007/978-1-4471-3454-1_12
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