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Vascular Imaging with Sonographic Contrast Agents

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Noninvasive Vascular Diagnosis

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Abstract

Contrast agents are used extensively in vascular imaging and are an essential part of most radiographic examinations such as angiography, computed tomography (CT) and magnetic resonance imaging (MRI). In general, contrast agents change a specific property of an organ with regard to its surrounding tissues thereby increasing the signal-to-noise ratio of blood and allowing improved imaging of a targeted vessel. The exact method by which this improved imaging is accomplished depends upon the type of examination being performed. With examinations such as upper gastrointestinal series, intravenous urography or CT scans, contrast is used to increase the density of a specific organ system or vessel relative to the surrounding tissues. Therefore, high molecular weight elements such as barium or iodine are ingested or injected into the body.

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References

  1. Bree RL, Platt JF, Bluth EI. Phase III clinical experience with a US contrast agent in the upper abdomen. Radiology 1996;201(Suppl):267.

    Google Scholar 

  2. Schlief R, Deichert, U. Hysterosalpingo-contrast sonography of the uterus and fallopian tubes: results of a clinical trial of a new contrast medium in 120 patients. Radiology 1991;178:213–215.

    PubMed  CAS  Google Scholar 

  3. Dietrich M, Suren A, Hinney B, Osmers R, Kuhn W. Evaluation of tubal patency by hysterocontrast sonography (HyCoSy, Echovist) and its correlation with laparoscopic findings. J Clin Ultrasound 1996;24:523–527.

    Article  PubMed  CAS  Google Scholar 

  4. Wible JH, Adams MD, Sherwin PF, et al. Noncardiac applications of Albunex. Invest Radiol 1994;29:S145–S148.

    Article  Google Scholar 

  5. Parker KJ, Tuthill TA, Lerner RM, Violante MR. A particulate contrast agent with potential for ultrasound imaging of the liver. Ultrasound Med Biol 1987;13:555–566.

    Article  PubMed  CAS  Google Scholar 

  6. Mattrey RF, Scheible FW, Gosink BB, Leopold GR, Long DM, Higgins CR. Perfluoroctylbromide: a liver/spleen-specific and tumor imaging ultrasound contrast material. Radiology 1982;145: 759–762.

    PubMed  CAS  Google Scholar 

  7. Mattrey RF, Strich G, Shelton RE, et al. Perfluorochemicals as US contrast agents for tumor imaging and hepatosplenography: preliminary clinical results. Radiology 1987;163:339–343.

    PubMed  CAS  Google Scholar 

  8. Behan M, O’Connell D, Mattrey R, Carney D. Perfluoroctylbromide as a contrast agent for CT and sonography: preliminary clinical results. AJR 1993;160:399–405.

    Article  PubMed  CAS  Google Scholar 

  9. Matsuda Y, Yabuuchi T. Hepatic tumors: US contrast enhancement with CO2 microbubbles. Radiology 1986;161:701–705.

    PubMed  CAS  Google Scholar 

  10. Kudo M, Tomita S, Tochio J. Sonography with intra-arterial infusion of carbon dioxide microbubbles (sonographic angiography): value in differential diagnosis of hepatic tumors. AJR 1992; 158: 65–74.

    Article  PubMed  CAS  Google Scholar 

  11. Forsberg F, Liu JB, Merton DA, Rawool NM, Goldberg BB. Parenchymal enhancement and tumor visualization using a new sonographic contrast agent. J Ultrasound Med 1995;14:949–957.

    PubMed  CAS  Google Scholar 

  12. The EchoGen contrast study group. Perflenapent emulsion: an ultrasound contrast agent for diagnostic radiology-multicenter, double-blind comparison with a placebo. Radiology 1998; 207:717–722.

    Google Scholar 

  13. Crouse L, Cheirif J, Hanly D, et al. Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of a phase III Albunex multicenter trial. J Am Coll Cardiol 1993;22: 1494–1500.

    Article  PubMed  CAS  Google Scholar 

  14. Schwartz K, Becher H, Schimpfky C, Vorwerk D, Bogdahn U, Schlief R. Doppler enhancement with SHU508A in multiple vascular regions. Radiology 1994;193:195–201.

    Google Scholar 

  15. Goldberg BB. Ultrasound contrast agents. In: Wells PNT (ed) Advances in ultrasound techniques and instrumentation. New York: Churchill Livingstone, 1993:35–46.

    Google Scholar 

  16. Schlief R. Ultrasound contrast agents. Cur Opin Radiol 1991;3:198–207.

    CAS  Google Scholar 

  17. Schlief R. Developments in echo-enhancing agents. Clin Radiol 1996;51(Suppl):5–7.

    PubMed  Google Scholar 

  18. Newhouse V, Hoover M, Ash S. The detection of blood impurities using ultrasound Doppler. Ultrasonic Imaging 1980;2:370–380.

    PubMed  CAS  Google Scholar 

  19. Goldberg BB, Liu JB, Forsberg F. Ultrasound contrast agents: a review. Ultrasound Med Biol 1994;20:319–333.

    Article  PubMed  CAS  Google Scholar 

  20. Ophir J, Parker KJ. Contrast agents in diagnostic ultrasound. Ultrasound Med Biol 1989;15:353–356.

    Google Scholar 

  21. Fan P, Czuwala P, Nanda N, Rosenthal S, Yoganathan A. Comparison of various agents in contrast enhancement of color Doppler flow images: an in vitro study. Ultrasound Med Biol 1993;19:45–57.

    Article  PubMed  CAS  Google Scholar 

  22. Forsberg F, Liu JB, Burns PN, Merton DA, Goldberg BB. Artifacts in ultrasound contrast agent studies. J Ultrasound Med 1994;13:357–365.

    PubMed  CAS  Google Scholar 

  23. Moriyasu F, Ban N, Nishida O, Nakamura T, Miyake T. Clinical application of an ultrasonic duplex system in the quantitative measurement of portal blood flow. J Clin Ultrasound 1986;14:579–588.

    Article  PubMed  CAS  Google Scholar 

  24. Zoli M, Marchesini G, Cordiani MR, et al. Echo-Doppler measurement of splanchnic blood flow in control and cirrhotic subjects. J Clin Ultrasound 1986;14:429–435.

    Article  PubMed  CAS  Google Scholar 

  25. Melany ML, Grant EG, Farooki S, McElroy D, Kimme-Smith C. The effect of ultrasound contrast agents on spectral velocities: an in-vitro evaluation of several agents. Presented at the Annual Meeting of the American Institute of Ultrasound in Medicine, March 24, 1998, Boston, Mass. Radiology (in press).

    Google Scholar 

  26. Gutberlet M, Venz S, Zendel W, Hosten N, Felix R. Do ultrasound contrast gents artifactually increase maximum Doppler shift? In vivo study of human common carotid arteries. J Ultrasound Med 1998;17:97–102.

    PubMed  CAS  Google Scholar 

  27. Petrick J, Zomack M, Schlief R. An investigation of the relationship between ultrasound echo enhancement and Doppler frequency shift using a pulsatile arterial flow phantom. Invest Radiol 1997;32:225–235.

    Article  PubMed  CAS  Google Scholar 

  28. Sponheim N, Myhrum M. An in vitro study on the influence of limited frequency resolution on contrast agent-enhanced Doppler signals. Ultrasonics 1996;34:599–601.

    Article  PubMed  CAS  Google Scholar 

  29. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996;51:50–55.

    PubMed  Google Scholar 

  30. Needleman L, Forsberg F. Contrast agents in ultrasound. Ultrasound Q 1996;13:121–138.

    Google Scholar 

  31. Burns PN, Powers JE, Hope-Simpson D, Uhlendorf V, Fritzsch T. Power Doppler imaging combined with contrast enhancing harmonic Doppler: new method for small vessel imaging. Radiology 1994;193(Suppl):366.

    Google Scholar 

  32. Harmon B, Grant EG, Wiegel B, Brown P. An open label study to assess the safety and efficacy of Albunex in lower extremity Doppler in patients with suspected deep venous thrombosis in the lower extremities. Presented at the American Roentgen Ray Society meeting May, 1995, Washington, DC.

    Google Scholar 

  33. Needleman L, Nack TL, Feld RI, Goldberg BB. Initial experience with an US contrast agent in upper-extremity venous thrombosis. Radiology 1992;185(Suppl):143.

    Google Scholar 

  34. Schlief R. Galactose based echo-enhancing agents. Proceedings of the symposium on ultrasound contrast agents. The leading edge in diagnostic ultrasound, Atlantic City, 1995:25–26.

    Google Scholar 

  35. Needleman, L, Goldberg BB, Feld RI, Merton DA, Liu JB. Evaluation of arterial disease in humans using an ultrasound contrast agent. J Ultrasound Med 1995;14(Suppl):48.

    Google Scholar 

  36. Langholz J, Schlief R, Schürmann R, Wanke M, Heidrich H. Contrast enhancement in leg vessels. Clin Radiol 1996;51(Suppl l):31–34.

    PubMed  Google Scholar 

  37. Fobbe F, Ohnesorge I, Dahl A, et al. Farbkodierte Duplexsonographie und Ultraschallkontrastmittel zur Untersuchung periphererArterien: Erste klinische Erfahrung. Ultraschall Med 1992;13:193–198.

    Article  PubMed  CAS  Google Scholar 

  38. Baien F, Allen C, Lees W. Ultrasound contrast agents. Clin Radiol 1994;49:77–82.

    Article  Google Scholar 

  39. Melany ML, Grant EG, Duerinckx AJ, Watts TM, Levine BS. Ability of a phase shift ultrasound contrast agent to improve imaging of the main renal arteries. Radiology 1997; 205:147–152.

    PubMed  CAS  Google Scholar 

  40. Braunschweig R, Stern W, Dadiban A, et al. Contrast enhanced colour Doppler studies of liver vessels. Echocardiography 1993;10:674.

    Google Scholar 

  41. Teefey SA, Middleton WD, Crowe TM, Peters MG. Doppler sonographic evaluation of the portal vein: effects of intravenous dodecafluoropentane. J Ultrasound Med 1997;16:641–645.

    PubMed  CAS  Google Scholar 

  42. Tessler FT, Gehring BJ, Gomes A, et. al. Diagnosis of portal vein thrombosis: value of color Doppler imaging. AJR 1991;157: 293–296.

    Article  PubMed  CAS  Google Scholar 

  43. Hausegger KA, Sternthal HM, Klein GE, Karaic R, Stauber R, Zenker G. Transjugular intrahepatic portosystemic shunt: angiographic follow-up and secondary interventions. Radiology 1994;191:177–181.

    PubMed  CAS  Google Scholar 

  44. Dodd GD, Zajko AB, Orons PD, Martin MS, Eichner LS, Santaguida. Detection of intrahepatic portosystemic shunt dysfunction: value of duplex Doppler sonography. AJR, 1995:164:1119–1124.

    Article  PubMed  Google Scholar 

  45. Forshager MC, Ferrai H, Finlay ED, Castaneda-Zuniga WR, Letourneau JG. Color Doppler sonography of transjugular intrahepatic portosystemic shunts (TIPS). AJR 1994;163:105–111.

    Article  Google Scholar 

  46. Furst G, Malms J, Heyer T, et al. Transjugular intrahepatic portosystemic shunts: improved evaluation with echo-enhanced color Doppler sonogrpahy, power Doppler sonography, and spectral duplex sonography. AJR 1998;170:1047–1054.

    Article  PubMed  CAS  Google Scholar 

  47. Uggowitzer MM, Kugler C, Machan L, et al. Value of echo-enhanced Doppler sonography in evaluation of transjugular intrahepatic portosystemic shunts. AJR 1987 170:1041–1046.

    Article  Google Scholar 

  48. Vorwerk D, Gehl H, Nelles A, Gunther R. Dynamic contrast medium-aided ultrasound venacavography in patients with caval filters. Ultraschall Med 1990;11:146–149.

    Article  PubMed  CAS  Google Scholar 

  49. Sitzer M, Furst G, Siebler M, Steinmetz H. Usefulness of an intravenous contrast medium in the characterization of high grade internal carotid stenosis with color Doppler assisted duplex imaging. Stroke 1994;25:385–389.

    Article  PubMed  CAS  Google Scholar 

  50. Jauss M, Kaps M, Keberle M, Haberbosch W, Dorndorf W. A comparison of transesophageal echocardiography and transcranial Doppler sonography with contrast medium for detection of patent foramen ovale. Stroke 1994;25:1265–1267.

    Article  PubMed  CAS  Google Scholar 

  51. Kloetzsch C, Janssen G, Berlit P. Transesophageal echocardiography and contrast transcranial Doppler in the detection of patent foramen ovale: experiences in 111 patients. Neurology 1994;44:1603–1606.

    Article  Google Scholar 

  52. Otis S, Rush M, Boyajian R. Contrast enhanced transcranial imaging: results of an American phase two study. Stroke 1995;26:203–209.

    Article  PubMed  CAS  Google Scholar 

  53. Rosenkranz K, Zendel W, Langer R, et al. Contrast-enhanced transcranial Doppler US with a new transpulmonary echo contrast agent based on saccharide microparticles. Radiology 1993;187: 439–443.

    PubMed  CAS  Google Scholar 

  54. Navabi DG, Droste DW, Kemeny V, Schulte-Altedorneburg G, Weber S, Ringelstein EB. Potential and limitations of echocon-trast-enhanced ultrasonography in acute stroke patients. Stroke 1998;29:949–954.

    Article  Google Scholar 

  55. Goertler M, Kross R, Baeumer M, et al. Diagnostic impact and prognostic relevance of early contrast enhanced transcranial color coded duplex sonography in acute stroke. Stroke 1998;29: 955–962.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Edward G. Grant
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  2. Michelle L Melany
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Editor information

Editors and Affiliations

  1. Robert C. Byrd Health Sciences Center, West Virginia University, Charleston, West Virginia, USA

    Ali F. AbuRahma MD, RVT (Professor of Surgery, Chief of Vascular Surgery, and Medical Director of Vascular Laboratory) (Professor of Surgery, Chief of Vascular Surgery, and Medical Director of Vascular Laboratory)

  2. North Coast Surgeons, 9850 Genessee Avenue, Suite 560, La Jolla, 92037, California, CA, USA

    John J. Bergan MD (Professor of Surgery) (Professor of Surgery)

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© 2000 Springer-Verlag London

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Grant, E.G., Melany, M.L. (2000). Vascular Imaging with Sonographic Contrast Agents. In: AbuRahma, A.F., Bergan, J.J. (eds) Noninvasive Vascular Diagnosis. Springer, London. https://doi.org/10.1007/978-1-4471-3837-2_34

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  • DOI: https://doi.org/10.1007/978-1-4471-3837-2_34

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3839-6

  • Online ISBN: 978-1-4471-3837-2

  • eBook Packages: Springer Book Archive

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