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The Role of Imaging in the Diagnosis and Staging of Primary and Recurrent Rectal Cancer

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Modern Management of Cancer of the Rectum

Abstract

Accurate pre-operative imaging is a central part of treatment decision making in the modern management of rectal cancer. The increasing use of neoadjuvant chemoradiation necessitates the identification of specific prognostic factors such as tumour penetration, nodal status, extramural venous invasion and most importantly, the relationship of the tumour edge to the circumferential resection margin. MRI has been the most accurate modality in the local staging of rectal cancer both pre-operatively, and to measure treatment response. Recurrent cancer usually requires a more tailored approach and also needs detailed imaging of the extent of disease. A compartment based system has been shown to aid surgical planning leading to improved outcomes.

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References

  1. Moore HG, Shoup M, Riedel E, et al. Colorectal cancer pelvic recurrences: determinants of resectability. Dis Colon Rectum. 2004;47:1599–606.

    Article  PubMed  Google Scholar 

  2. Georgiou PA, Tekkis PP, Constantinides VA, et al. Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal cancer. Eur J Cancer. 2013;49:72–81.

    Article  PubMed  Google Scholar 

  3. Schaefer O, Langer M. Detection of recurrent rectal cancer with CT, MRI and PET/CT. Eur Radiol. 2007;17:2044–54.

    Article  CAS  PubMed  Google Scholar 

  4. Colosio A, Fornes P, Soyer P, et al. Local colorectal cancer recurrence: pelvic MRI evaluation. Abdom Imaging. 2013;38:72–81.

    Article  CAS  PubMed  Google Scholar 

  5. Cedermark B, Johansson H, Rutqvist LE, et al. The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. A prospective randomized trial. Stockholm Colorectal Cancer Study Group. Cancer. 1995;75:2269–75.

    Article  CAS  PubMed  Google Scholar 

  6. Folkesson J, Birgisson H, Pahlman L, et al. Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol. 2005;23:5644–50.

    Article  PubMed  Google Scholar 

  7. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–46.

    Article  CAS  PubMed  Google Scholar 

  8. Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373:811–20.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Wibe A, Rendedal PR, Svensson E, et al. Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg. 2002;89:327–34.

    Article  CAS  PubMed  Google Scholar 

  10. Adam IJ, Mohamdee MO, Martin IG, et al. Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet. 1994;344:707–11.

    Article  CAS  PubMed  Google Scholar 

  11. Heald RJ. The ‘Holy Plane’ of rectal surgery. J R Soc Med. 1988;81:503–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  12. Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1:1479–82.

    Article  CAS  PubMed  Google Scholar 

  13. Chand M, Heald RJ, Brown G. The importance of not overstaging mesorectal lymph nodes seen on MRI. Colorectal Dis. 2013;15:1201–4.

    Article  CAS  PubMed  Google Scholar 

  14. Quirke P, Steele R, Monson J, et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet. 2009;373:821–8.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Heald RJ, O’Neill BD, Moran B, et al. MRI in predicting curative resection of rectal cancer: new dilemma in multidisciplinary team management. BMJ. 2006;333:808.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006;94:351–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Brown G. Staging rectal cancer: endoscopic ultrasound and pelvic MRI. Cancer Imaging. 2008;8(Spec No A):S43–5.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Radcliffe A, Brown G. Will MRI provide maps of lines of excision for rectal cancer? Lancet. 2001;357:495–6.

    Article  CAS  PubMed  Google Scholar 

  19. Brown G, Radcliffe AG, Newcombe RG, et al. Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg. 2003;90:355–64.

    Article  CAS  PubMed  Google Scholar 

  20. MERCURY Study Group. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ. 2006;333:779.

    Article  PubMed Central  Google Scholar 

  21. Koh DM, Hughes M, Husband JE. Cross-sectional imaging of nodal metastases in the abdomen and pelvis. Abdom Imaging. 2006;31:632–43.

    Article  CAS  PubMed  Google Scholar 

  22. Koh DM, Smith NJ, Swift RI, et al. The relationship between MR demonstration of extramural venous invasion and nodal disease in rectal cancer. Clin Med Oncol. 2008;2:267–73.

    PubMed Central  PubMed  Google Scholar 

  23. Brown G. Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer. Br J Radiol. 2005;78(Spec No 2):S117–27.

    Article  PubMed  Google Scholar 

  24. Burton S, Brown G, Daniels I, et al. MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys. 2006;65:445–51.

    Article  PubMed  Google Scholar 

  25. Koh DM, Chau I, Tait D, et al. Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2008;71:456–61.

    Article  PubMed  Google Scholar 

  26. O’Neill BD, Brown G, Heald RJ, et al. Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer. Lancet Oncol. 2007;8:625–33.

    Article  PubMed  Google Scholar 

  27. Potter KC, Husband JE, Houghton SL, et al. Diagnostic accuracy of serial CT/magnetic resonance imaging review vs positron emission tomography/CT in colorectal cancer patients with suspected and known recurrence. Dis Colon Rectum. 2009;52:253–9.

    Article  PubMed  Google Scholar 

  28. Taylor FG, Quirke P, Heald RJ, et al. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter. European study Ann Surg. 2011;253:711–9.

    Article  Google Scholar 

  29. Evans J, Patel U, Brown G. Rectal cancer: primary staging and assessment after chemoradiotherapy. Semin Radiat Oncol. 2011;21:169–77.

    Article  PubMed  Google Scholar 

  30. Patel UB, Taylor F, Blomqvist L, et al. Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience. J Clin Oncol. 2011;29:3753–60.

    Article  PubMed  Google Scholar 

  31. Patel UB, Brown G, Rutten H, et al. Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer. Ann Surg Oncol. 2012;19:2842–52.

    Article  PubMed  Google Scholar 

  32. Yu S, Tait D, Chau I, Brown G. MRI predictive factors for tumor response in rectal cancer following neoadjuvant chemoradiation therapy – implications for induction chemotherapy? Int J Radiat Oncol Biol Phys. 2013;87:505–11.

    Article  PubMed  Google Scholar 

  33. Chand MEJ, Swift I, Tekkis PP, West NP, Stamp GWH, Heald RJ, Brown G. The prognostic significance of post-chemoradiotherapy high- resolution MRI and histopathology detected extramural venous invasion in rectal cancer. Ann Surg. 2014. [Epub ahead of print].

    Google Scholar 

  34. Salerno G, Daniels IR, Moran BJ, et al. Clarifying margins in the multidisciplinary management of rectal cancer: the MERCURY experience. Clin Radiol. 2006;61:916–23.

    Article  CAS  PubMed  Google Scholar 

  35. Taylor F, Mangat N, Swift IR, et al. Proforma-based reporting in rectal cancer. Cancer Imaging. 2010;10(Spec no A):S142–50.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Taylor FG, Swift RI, Blomqvist L, et al. A systematic approach to the interpretation of preoperative staging MRI for rectal cancer. AJR Am J Roentgenol. 2008;191:1827–35.

    Article  PubMed  Google Scholar 

  37. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471–4.

    Article  PubMed  Google Scholar 

  38. Puli SR, Reddy JB, Bechtold ML, et al. Accuracy of endoscopic ultrasound to diagnose nodal invasion by rectal cancers: a meta-analysis and systematic review. Ann Surg Oncol. 2009;16:1255–65.

    Article  PubMed  Google Scholar 

  39. Merkel S, Mansmann U, Papadopoulos T, et al. The prognostic inhomogeneity of colorectal carcinomas Stage III: a proposal for subdivision of Stage III. Cancer. 2001;92:2754–9.

    Article  CAS  PubMed  Google Scholar 

  40. Cawthorn SJ, Parums DV, Gibbs NM, et al. Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal cancer. Lancet. 1990;335:1055–9.

    Article  CAS  PubMed  Google Scholar 

  41. Steel MC, Woods R, Mackay JM, et al. Extent of mesorectal invasion is a prognostic indicator in T3 rectal carcinoma. ANZ J Surg. 2002;72:483–7.

    Article  PubMed  Google Scholar 

  42. Miyoshi M, Ueno H, Hashiguchi Y, et al. Extent of mesorectal tumor invasion as a prognostic factor after curative surgery for T3 rectal cancer patients. Ann Surg. 2006;243:492–8.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Cianchi F, Messerini L, Comin CE, et al. Pathologic determinants of survival after resection of T3N0 (Stage IIA) colorectal cancer: proposal for a new prognostic model. Dis Colon Rectum. 2007;50:1332–41.

    Article  PubMed  Google Scholar 

  44. Yoshida K, Yoshimatsu K, Otani T, et al. The depth of tumor invasion beyond the outer border of the muscularis propria as a prognostic factor for T3 rectal/rectosigmoid cancer. Anticancer Res. 2008;28:1773–8.

    PubMed  Google Scholar 

  45. Willett CG, Badizadegan K, Ancukiewicz M, et al. Prognostic factors in stage T3N0 rectal cancer: do all patients require postoperative pelvic irradiation and chemotherapy? Dis Colon Rectum. 1999;42:167–73.

    Article  CAS  PubMed  Google Scholar 

  46. Merkel S, Mansmann U, Siassi M, et al. The prognostic inhomogeneity in pT3 rectal carcinomas. Int J Colorectal Dis. 2001;16:298–304.

    Article  CAS  PubMed  Google Scholar 

  47. Moran B, Brown G, Cunningham D, et al. Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: ‘y’ ‘u’ and ‘p’ need ‘mr’ and ‘ct’. Colorectal Dis. 2008;10:242–3.

    Article  CAS  PubMed  Google Scholar 

  48. Merkel S, Weber K, Schellerer V, et al. Prognostic subdivision of ypT3 rectal tumours according to extension beyond the muscularis propria. Br J Surg. 2014;101:566–72.

    Article  CAS  PubMed  Google Scholar 

  49. Taylor FG, Quirke P, Heald RJ, et al. One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Br J Surg. 2011;98:872–9.

    Article  CAS  PubMed  Google Scholar 

  50. Blomqvist L, Rubio C, Holm T, et al. Rectal adenocarcinoma: assessment of tumour involvement of the lateral resection margin by MRI of resected specimen. Br J Radiol. 1999;72:18–23.

    Article  CAS  PubMed  Google Scholar 

  51. Taylor FG, Quirke P, Heald RJ, et al. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study that recruited consecutive patients with rectal cancer. Ann Surg. 2011;253(4):711–9.

    Google Scholar 

  52. Chand M, Moran BJ, Jones RG, et al. Lymph node status does not predict local recurrence in the total mesorectal excision era. Dis Colon Rectum. 2014;57:127–9.

    Article  PubMed  Google Scholar 

  53. Brown G, Richards CJ, Bourne MW, et al. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology. 2003;227:371–7.

    Article  PubMed  Google Scholar 

  54. Dworak O. Morphology of lymph nodes in the resected rectum of patients with rectal carcinoma. Pathol Res Pract. 1991;187:1020–4.

    Article  CAS  PubMed  Google Scholar 

  55. Ashraf S, Hompes R, Slater A, et al. A critical appraisal of endorectal ultrasound and transanal endoscopic microsurgery and decision-making in early rectal cancer. Colorectal Dis. 2012;14:821–6.

    Article  CAS  PubMed  Google Scholar 

  56. Koh DM, Brown G, Temple L, et al. Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur Radiol. 2005;15:1650–7.

    Article  CAS  PubMed  Google Scholar 

  57. Talbot IC, Ritchie S, Leighton MH, et al. The clinical significance of invasion of veins by rectal cancer. Br J Surg. 1980;67:439–42.

    Article  CAS  PubMed  Google Scholar 

  58. Talbot IC, Ritchie S, Leighton MH, et al. Spread of rectal cancer within veins. Histologic features and clinical significance. Am J Surg. 1981;141:15–7.

    Article  CAS  PubMed  Google Scholar 

  59. Dukes CE, Bussey HJ. Venous spread in rectal cancer: (section of proctology). Proc R Soc Med. 1941;34:571–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  60. Madison MS, Dockerty MB, Waugh JM. Venous invasion in carcinoma of the rectum as evidenced by venous radiography. Surg Gynecol Obstet. 1954;92:170–8.

    Google Scholar 

  61. Ptok H, Meyer F, Steinert R, et al. No prognostic impact of isolated lymphovascular invasion after radical resection of rectal cancer–results of a multicenter observational study. Int J Colorectal Dis. 2007;22:749–56.

    Article  PubMed  Google Scholar 

  62. Minsky BD, Mies C, Recht A, et al. Resectable adenocarcinoma of the rectosigmoid and rectum. II. The influence of blood vessel invasion. Cancer. 1988;61:1417–24.

    Article  CAS  PubMed  Google Scholar 

  63. Quirke P, Morris E. Reporting colorectal cancer. Histopathology. 2007;50:103–12.

    Article  CAS  PubMed  Google Scholar 

  64. Williams GT, Quirke P, Shepherd NA. Dataset for colorectal cancer. 2nd ed. The Royal College of Pathologists; London. 2007. [updated Sep 2007; cited 2013 10/10/2013].

    Google Scholar 

  65. Smith NJ, Shihab O, Arnaout A, et al. MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol. 2008;191:1517–22.

    Article  PubMed  Google Scholar 

  66. Smith NJ, Barbachano Y, Norman AR, et al. Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. Br J Surg. 2008;95:229–36.

    Article  CAS  PubMed  Google Scholar 

  67. Messenger DE, Driman DK, McLeod RS, et al. Current practice patterns among pathologists in the assessment of venous invasion in colorectal cancer. J Clin Pathol. 2011;64:983–9.

    Article  PubMed  Google Scholar 

  68. Messenger DE, Driman DK, Kirsch R. Developments in the assessment of venous invasion in colorectal cancer: implications for future practice and patient outcome. Hum Pathol. 2012;43:965–73.

    Article  PubMed  Google Scholar 

  69. Chand M, Bhoday J, Bhome R, et al. mrEMVI status should be used in addition to pEMVI for treatment decision making in rectal cancer to prevent under-reporting of extramural venous invasion. Eur J Surg Oncol. 2013;39:S66.

    Article  Google Scholar 

  70. Chand M, Swift RI, Tekkis PP, et al. Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer. Br J Cancer. 2014;110:19–25.

    Article  CAS  PubMed  Google Scholar 

  71. Chand M, Bhangu A, Wotherspoon A, et al. EMVI-positive stage II rectal cancer has similar clinical outcomes as stage III disease following pre-operative chemoradiotherapy. Ann Oncol. 2014;25:858–63.

    Article  CAS  PubMed  Google Scholar 

  72. Moran BJ. Predicting the risk and diminishing the consequences of anastomotic leakage after anterior resection for rectal cancer. Acta Chir Iugosl. 2010;57:47–50.

    Article  CAS  PubMed  Google Scholar 

  73. Salerno G, Daniels IR, Brown G. Magnetic resonance imaging of the low rectum: defining the radiological anatomy. Colorectal Dis. 2006;8 Suppl 3:10–3.

    Article  PubMed  Google Scholar 

  74. Salerno G, Sinnatamby C, Branagan G, et al. Defining the rectum: surgically, radiologically and anatomically. Colorectal Dis. 2006;8 Suppl 3:5–9.

    Article  PubMed  Google Scholar 

  75. Beyond TME Collaborative. Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes. Br J Surg. 2013;100:E1–33.

    Article  Google Scholar 

  76. Balzarini L, Ceglia E, D’Ippolito G, et al. Local recurrence of rectosigmoid cancer: what about the choice of MRI for diagnosis? Gastrointest Radiol. 1990;15:338–42.

    Article  CAS  PubMed  Google Scholar 

  77. Pema PJ, Bennett WF, Bova JG, et al. CT vs MRI in diagnosis of recurrent rectosigmoid carcinoma. J Comput Assist Tomogr. 1994;18:256–61.

    Article  CAS  PubMed  Google Scholar 

  78. Beyond TME Collaborative. Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes. Br J Surg. 2013;100:1009–14.

    Google Scholar 

  79. Messiou C, Chalmers AG, Boyle K, et al. Pre-operative MR assessment of recurrent rectal cancer. Br J Radiol. 2008;81:468–73.

    Article  CAS  PubMed  Google Scholar 

  80. Heriot K. Rectal cancer recurrence: factors and mechanisms. Colorectal Dis. 2000;2:126–36.

    Article  CAS  PubMed  Google Scholar 

  81. Harji DP, Sagar PM, Boyle K, et al. Surgical resection of recurrent colonic cancer. Br J Surg. 2013;100:950–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Manish Chand MBBS, BSc, MRCS .

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Chand, M., Balyasnikova, S., Brown, G. (2015). The Role of Imaging in the Diagnosis and Staging of Primary and Recurrent Rectal Cancer. In: Longo, W., Reddy, V., Audisio, R. (eds) Modern Management of Cancer of the Rectum. Springer, London. https://doi.org/10.1007/978-1-4471-6609-2_6

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